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GENE：HUS1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol HUS1
FullNmae HUS1 checkpoint clamp component
LocusType gene with protein product
Status Approved
HGNC_id HGNC:5309
EnsembleID ENSG00000136273
Uniprot O60921

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
HUS1 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
HUS1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
HUS1 GO:0000077,GO:0000723,GO:0000724,GO:0001932,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006281,GO:0006289,GO:0006974,GO:0009411,GO:0009792,GO:0030896,GO:0031573,GO:0033314,GO:0035861,GO:0044778,GO:0071479

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
HUS1 hsa:3364 path:hsa04218 Cellular senescence - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
HUS1 RAD1 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 15871698 16216273 16697054 16713580 16731526 16805667 16879101 16885023 17102137 17116885 17129768 17296725 17303408 17384638 17395641 17426133 17493829 17582221 17855402 18469862 18543256 18677104 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 23507534 26192618 8943031 9524127 interaction type N/A ACSN
RAD17 HUS1 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16885023 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 26192618 8943031 9524127 interaction type N/A ACSN
HUS1 TDG 14726013 15459660 15703371 16697054 16713580 17129768 17493829 17855402 18543256 19847258 26192618 8943031 9524127 interaction type N/A ACSN
HUS1 ORC1 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16885023 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 26192618 8943031 9524127 interaction type N/A ACSN
HUS1 ORC2 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16885023 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 26192618 8943031 9524127 interaction type N/A ACSN
HUS1 ORC3 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16885023 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 26192618 8943031 9524127 interaction type N/A ACSN
HUS1 ORC4 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16885023 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 26192618 8943031 9524127 interaction type N/A ACSN
HUS1 ORC5 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16885023 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 26192618 8943031 9524127 interaction type N/A ACSN
HUS1 ORC6 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16885023 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 26192618 8943031 9524127 interaction type N/A ACSN
HUS1 MCM2 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16885023 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 26192618 8943031 9524127 interaction type N/A ACSN
HUS1 MCM3 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16885023 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 26192618 8943031 9524127 interaction type N/A ACSN
HUS1 MCM4 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16885023 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 26192618 8943031 9524127 interaction type N/A ACSN
HUS1 MCM5 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16885023 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 26192618 8943031 9524127 interaction type N/A ACSN
HUS1 MCM6 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16885023 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 26192618 8943031 9524127 interaction type N/A ACSN
HUS1 MCM7 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16885023 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 26192618 8943031 9524127 interaction type N/A ACSN
HUS1 CDT1 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16885023 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 26192618 8943031 9524127 interaction type N/A ACSN
HUS1 CDC6 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16885023 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 26192618 8943031 9524127 interaction type N/A ACSN
HUS1 CDC45 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16885023 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 26192618 8943031 9524127 interaction type N/A ACSN
HUS1 RPA1 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16885023 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 26192618 8943031 9524127 interaction type N/A ACSN
HUS1 RPA2 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16885023 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 26192618 8943031 9524127 interaction type N/A ACSN
HUS1 RPA3 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16885023 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 26192618 8943031 9524127 interaction type N/A ACSN
HUS1 CDC7 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16885023 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 26192618 8943031 9524127 interaction type N/A ACSN
HUS1 DBF4 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16885023 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 26192618 8943031 9524127 interaction type N/A ACSN
ATRIP HUS1 10884395 11877377 12086603 12766152 14726013 14988723 15136767 15175241 15459660 15485915 15703371 15798197 16530042 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 26192618 8943031 9524127 interaction type N/A ACSN
ATR HUS1 10884395 11877377 12086603 12766152 14726013 14988723 15136767 15175241 15459660 15485915 15703371 15798197 16530042 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 26192618 8943031 9524127 interaction type N/A ACSN
CLSPN HUS1 10884395 11877377 12086603 12766152 14726013 14988723 15136767 15175241 15459660 15485915 15703371 15798197 16530042 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 26192618 8943031 9524127 interaction type N/A ACSN
HUS1 TIPIN 10884395 11877377 12086603 12766152 14726013 14988723 15136767 15175241 15459660 15485915 15703371 15798197 16530042 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 26192618 8943031 9524127 interaction type N/A ACSN
HUS1 CHEK1 10884395 11877377 12086603 12766152 14726013 14988723 15136767 15175241 15459660 15485915 15703371 15798197 16530042 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 26192618 8943031 9524127 interaction type N/A ACSN

Source Target Pmid Interactiontype Methods Database
YWHAZ HUS1 20005715 interaction type N/A PSP,SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 HUS1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 HUS1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 HUS1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 HUS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA HUS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF HUS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 HUS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 HUS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 HUS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS HUS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A HUS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF HUS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PRDM14 HUS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 HUS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000355E82 HUS1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003E5ECC HUS1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000214763 HUS1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000047A8F HUS1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000006372A HUS1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001C0099 HUS1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003FBC84 HUS1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000041FA2C HUS1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E HUS1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000C5969 HUS1 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
HUS1 RAD9A 25361965 interaction type N/A PTMCode2
RAD9A HUS1 25361965 interaction type N/A PTMCode2
HUS1 RAD1 25361965 interaction type N/A PTMCode2
RAD1 HUS1 25361965 interaction type N/A PTMCode2
HUS1 PCNA 25361965 interaction type N/A PTMCode2
PCNA HUS1 25361965 interaction type N/A PTMCode2
HUS1 RAD17 25361965 interaction type N/A PTMCode2
RAD17 HUS1 25361965 interaction type N/A PTMCode2
HUS1 RAD9B 25361965 interaction type N/A PTMCode2
RAD9B HUS1 25361965 interaction type N/A PTMCode2
HUS1 DNAJC7 25361965 interaction type N/A PTMCode2
DNAJC7 HUS1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
C4ORF46 HUS1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ZBTB14 HUS1 25348397 N/A physical interaction ComPPI
PCNA HUS1 11077446 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
MSH3 HUS1 25348397 N/A physical interaction ComPPI
TP53BP1 HUS1 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
SLAMF1 HUS1 25348397 N/A physical interaction ComPPI
ATR HUS1 25348397 N/A physical interaction ComPPI
COPS5 HUS1 25348397 N/A physical interaction ComPPI
YWHAZ HUS1 15161933 24234451 25348397 physical association pull down ComPPI,IntAct
PDGFRB HUS1 25348397 N/A physical interaction ComPPI
PLAUR HUS1 25348397 N/A physical interaction ComPPI
RPA1 HUS1 14525934 15897895 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
FEN1 HUS1 25348397 N/A physical interaction ComPPI
HUS1 RAD1 10359610 14624239 19464297 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,cosedimentation through density gradient,x-ray crystallography,physical interaction,in vivo ComPPI,IntAct
HUS1 RAD9A 10359610 14525934 14624239 19464297 24234451 25348397 9872989 physical association anti bait coimmunoprecipitation,two hybrid,cosedimentation through density gradient,experimental interaction detection,x-ray crystallography,physical interaction,two hybrid array,in vitro,in vivo,two hybrid prey pooling approach ComPPI,HPRD,IntAct
HUS1 DNAJC7 25348397 N/A physical interaction,in vitro,in vivo ComPPI
HUS1 RAD17 10884395 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
HUS1 HUS1B 11944979 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
HUS1 RPA2 14525934 15897895 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
HUS1 PSMA2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
HUS1 HDAC1 10846170 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
HUS1 MSH2 25348397 N/A physical interaction ComPPI
HUS1 MSH6 25348397 N/A physical interaction ComPPI
HUS1 CD200 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
HUS1 HECW2 25348397 N/A physical interaction ComPPI
HUS1 RHNO1 25348397 N/A physical interaction ComPPI
HUS1 SLAMF7 25348397 N/A physical interaction ComPPI
HUS1 SCN2B 25348397 N/A physical interaction ComPPI
HUS1 LAMP3 25348397 N/A physical interaction ComPPI
HUS1 CD70 25348397 N/A physical interaction ComPPI
HUS1 VSIG1 25348397 N/A physical interaction ComPPI
HUS1 CD79B 25348397 N/A physical interaction ComPPI
HUS1 ARPC5 25348397 N/A physical interaction ComPPI
HUS1 FANCA 25348397 N/A physical interaction ComPPI
HUS1 ALDOB 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
HUS1 PSD 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
HUS1 STRAP 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
HUS1 SDCBP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HUS1 NTAQ1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HUS1 BRCA1 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
YWHAQ HUS1 25348397 N/A physical interaction ComPPI
HPRT1 HUS1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
DCUN1D5 HUS1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RAD9B HUS1 14525934 14611806 N/A experimental interaction detection HPRD
HUS1 PCNA 11077446 27898060 stimulant N/A OmniPath

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