GENE：MTF1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | MTF1 |
| FullNmae | metal regulatory transcription factor 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:7428 |
| EnsembleID | ENSG00000188786 |
| Uniprot | Q14872 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| MTF1 | cuproptosis | 37561332 | Cuproptosis-related genes LIPT1, MTF1, GLS and CDKN2A were highly expressed in AML, while FDX1, LIAS, DLD, DLAT, PDHA1, SLC31A1 and ATP7B were lowly expressed in AML. | retulator signature |
| MTF1 | cuproptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| MTF1 | cuproptosis | 36882769 | Knock out lead to sensitive of cuproptosis. | suppressor |
| MTF1 | cuproptosis | 38168558 | Among the CRGs in our study, 7 genes were pro-cuproptosis genes (FDX1, LIPT1, LIAS, DLD, PDHA1, DLAT and PDHB), 3 genes were anti-cuproptosis genes (MTF1, CDKN2A and GLS), and 2 genes were copper transporters (SLC31A1 and ATP7B). | suppressor |
| MTF1 | cuproptosis | 37803139 | The expression levels of both phosphorylated ERK1/2 (p-ERK1/2) and metal-responsive transcription factor 1 (MTF1) have been employed as the indicators of bioavailable Cu levels. | indicator |
| MTF1 | cuproptosis | 38495196 | Cuproptosis-related genes were manually curated, and differentially expressed cuproptosis-related genes (DECuGs) were identified.Then, the 16 DECuGs were obtained by the intersection of the 5018 DEGs and 63 cuproptosis-related genes. | 63 cuproptosis-related genes |
| MTF1 | cuproptosis | 37983626 | NFE2L2, NLRP3, GLS, LIPT1, and MTF1 were identified as potential cuproptosis predictors, thus shedding new light on ischemic stroke pathogenesis and heterogeneity. | predictior |
| MTF1 | cuproptosis | 38348451 | A transcription factor involved in metal homeostasis. It may regulate copper-related genes and impact cuproptosis susceptibility. | CRGs in the cuproptosis pathway |
| MTF1 | cuproptosis | 36313717 | The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in聽Table S1. | Cuproptosis genes related mitochondrial respiration |
| MTF1 | cuproptosis | 36010978 | Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. | Cuproptosis-related genes |
| MTF1 | cuproptosis | 36118866 | PDH complex | cuproptosis gene |
| MTF1 | cuproptosis | 36568423 | Additionally, 41 cuproptosis regulators were obtained from the previous publications. | cuproptosis-related genes |
| MTF1 | cuproptosis | 36505872 | A total of 44 cuproptosis-related genes were extracted from known literature. | cuproptosis-related genes |
| MTF1 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| MTF1 | GO:0000978,GO:0000978,GO:0000987,GO:0001228,GO:0001228,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0006351,GO:0006357,GO:0006979,GO:0007417,GO:0010038,GO:0035035,GO:0045944,GO:0045944,GO:0046686,GO:0046872,GO:0071294,GO:1990079,GO:1990837 |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | MTF1 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | MTF1 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| CEBPA | MTF1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | MTF1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | MTF1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | MTF1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | MTF1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | MTF1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| VDR | MTF1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ATM | MTF1 | 12926986 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000272039 | MTF1 | 20371350 25416803 | mrna cleavage,inhibition | nucleotide sequence identification | TarBase |
| URS00002FC5B0 | MTF1 | 20371350 22473208 25416803 | mrna cleavage,inhibition | nucleotide sequence identification,clip | TarBase |
| URS000039E1E1 | MTF1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00002075FA | MTF1 | 22473208 23622248 25416803 | mrna cleavage,inhibition | clip,clash | TarBase |
| URS0000306C70 | MTF1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004719AB | MTF1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000042E1F | MTF1 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000600E6 | MTF1 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003D8730 | MTF1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000076B539 | MTF1 | 21572407 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000085F64 | MTF1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000260A3A | MTF1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001383CF | MTF1 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005ECFE5 | MTF1 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000037D7E5 | MTF1 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003883FE | MTF1 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005D986D | MTF1 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000508C13 | MTF1 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000021D08 | MTF1 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004818BD | MTF1 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075D50C | MTF1 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001941B8 | MTF1 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001A7F58 | MTF1 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000298BA3 | MTF1 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000DDD35 | MTF1 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002B3783 | MTF1 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| HNRNPC | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| DDX21 | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| HSPA8 | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| DHX15 | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| RPS7 | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| DRG1 | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| NPM1 | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| VIM | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| RPL11 | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| DDX17 | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| RPL10A | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| H4C1 | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| RPL10 | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| PRKDC | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| CREBBP | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| EP300 | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| DHX9 | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| MYBBP1A | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| RPL18A | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| SF3B1 | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| NONO | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| COPA | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| AP1M1 | MTF1 | 14525934 16189514 19060904 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
| PARP1 | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| RPS3A | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| XRCC5 | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| HSPA1A | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| HSPA1B | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| HNRNPU | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| RPL28 | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| EEF1A1 | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| PRMT5 | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| DDX5 | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| RBM10 | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| CLTC | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| RPS6 | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| RPS18 | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| RPS13 | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| RPL4 | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| EXOSC10 | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| RPLP0 | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| HNRNPA2B1 | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| SRSF1 | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| SMC1A | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| RPL7A | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| LMNB1 | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| PHB2 | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| SUPT16H | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| XPC | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| HSPA9 | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| GNL3 | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| RPL7 | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| DDX3X | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| RBMX | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| RPL5 | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| HNRNPH1 | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| NOP56 | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| SNRNP200 | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| RPL23A | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| SMARCA5 | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| RPS9 | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| EFTUD2 | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| HNRNPM | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| HSPA14 | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| RPL14 | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| RRP1B | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| PRPF19 | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| UGGT1 | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| SF3B2 | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| DDX3Y | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| ILF3 | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| EEF1A2 | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| HNRNPA1 | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| RPL8 | MTF1 | 25348397 | N/A | physical interaction | ComPPI |
| MTF1 | DNAJC2 | 25348397 | N/A | physical interaction | ComPPI |
| MTF1 | PRPF8 | 25348397 | N/A | physical interaction | ComPPI |
| MTF1 | NCL | 25348397 | N/A | physical interaction | ComPPI |
| MTF1 | RPL3 | 25348397 | N/A | physical interaction | ComPPI |
| MTF1 | RBM28 | 25348397 | N/A | physical interaction | ComPPI |
| MTF1 | NAT10 | 25348397 | N/A | physical interaction | ComPPI |
| MTF1 | GTPBP4 | 25348397 | N/A | physical interaction | ComPPI |
| MTF1 | NOP2 | 25348397 | N/A | physical interaction | ComPPI |
| MTF1 | RPS4X | 25348397 | N/A | physical interaction | ComPPI |
| MTF1 | RPS3 | 25348397 | N/A | physical interaction | ComPPI |
| MTF1 | DHX30 | 25348397 | N/A | physical interaction | ComPPI |
| MTF1 | RSL1D1 | 25348397 | N/A | physical interaction | ComPPI |
| MTF1 | CHD4 | 25348397 | N/A | physical interaction | ComPPI |
| MTF1 | RPS16 | 25348397 | N/A | physical interaction | ComPPI |
| MTF1 | RPS8 | 25348397 | N/A | physical interaction | ComPPI |
| MTF1 | NKRF | 25348397 | N/A | physical interaction | ComPPI |
| MTF1 | PDCD11 | 25348397 | N/A | physical interaction | ComPPI |
| MTF1 | ZC3H15 | 25348397 | N/A | physical interaction | ComPPI |
| MTF1 | RPS19 | 25348397 | N/A | physical interaction | ComPPI |
| MTF1 | RPL15 | 25348397 | N/A | physical interaction | ComPPI |
| MTF1 | RPL35A | 25348397 | N/A | physical interaction | ComPPI |
| MTF1 | DDX18 | 25348397 | N/A | physical interaction | ComPPI |
| MTF1 | RPS11 | 25348397 | N/A | physical interaction | ComPPI |
| MTF1 | IGF2BP1 | 25348397 | N/A | physical interaction | ComPPI |
| MTF1 | MATR3 | 25348397 | N/A | physical interaction | ComPPI |
| MTF1 | FBL | 25348397 | N/A | physical interaction | ComPPI |
| MTF1 | RPL19 | 25348397 | N/A | physical interaction | ComPPI |
| MTF1 | RPL27 | 25348397 | N/A | physical interaction | ComPPI |
| MTF1 | NOC2L | 25348397 | N/A | physical interaction | ComPPI |
| MTF1 | DDX27 | 25348397 | N/A | physical interaction | ComPPI |
| MTF1 | HNRNPA1L2 | 25348397 | N/A | physical interaction | ComPPI |
| MTF1 | RBMXL1 | 25348397 | N/A | physical interaction | ComPPI |
| MTF1 | RPLP0P6 | 25348397 | N/A | physical interaction | ComPPI |
| MTF1 | ATAD3A | 25348397 | N/A | physical interaction | ComPPI |
| MTF1 | ATAD3B | 25348397 | N/A | physical interaction | ComPPI |
| MTF1 | EEF1A1P5 | 25348397 | N/A | physical interaction | ComPPI |
| PRKG2 | MTF1 | 11923282 27898060 | N/A | N/A | OmniPath |