Gene Information gene info

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GENE：RFC5

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol RFC5
FullNmae replication factor C subunit 5
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9973
EnsembleID ENSG00000111445
Uniprot P40937

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
RFC5 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RFC5 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RFC5 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RFC5 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
RFC5 GO:0003677,GO:0003689,GO:0003689,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005663,GO:0005663,GO:0005663,GO:0006260,GO:0006261,GO:0006261,GO:0006281,GO:0006281,GO:0016887,GO:0017116,GO:0019899,GO:0031390,GO:0032508,GO:1900264

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
RFC5 hsa:5985 path:hsa03030 DNA replication - Homo sapiens (human)
RFC5 hsa:5985 path:hsa03410 Base excision repair - Homo sapiens (human)
RFC5 hsa:5985 path:hsa03420 Nucleotide excision repair - Homo sapiens (human)
RFC5 hsa:5985 path:hsa03430 Mismatch repair - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
RFC1 RFC5 14624239 26192618 interaction type N/A ACSN
RFC2 RFC5 14624239 26192618 interaction type N/A ACSN
RFC3 RFC5 14624239 26192618 interaction type N/A ACSN
RFC4 RFC5 14624239 26192618 interaction type N/A ACSN
RFC5 PCNA 26192618 interaction type N/A ACSN
EED RFC5 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
XIAP RFC5 23180781 25416956 physical association two hybrid InnateDB

Source Target Pmid Interactiontype Methods Database
E2F4 RFC5 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 RFC5 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SPI1 RFC5 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000AA464 RFC5 20304954 25416803 mrna cleavage,inhibition array technology TarBase
URS000003FD55 RFC5 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002004E0 RFC5 20371350 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000AF45F RFC5 20371350 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000083D87 RFC5 20371350 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000272A92 RFC5 20371350 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000010BD8D RFC5 20371350 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
POLE RFC5 25361965 interaction type N/A PTMCode2
RFC5 POLE 25361965 interaction type N/A PTMCode2
ATP6V0A1 RFC5 25361965 interaction type N/A PTMCode2
RFC5 ATP6V0A1 25361965 interaction type N/A PTMCode2
BRD2 RFC5 25361965 interaction type N/A PTMCode2
RFC5 BRD2 25361965 interaction type N/A PTMCode2
PCNA RFC5 25361965 interaction type N/A PTMCode2
RFC5 PCNA 25361965 interaction type N/A PTMCode2
RFC4 RFC5 25361965 interaction type N/A PTMCode2
RFC5 RFC4 25361965 interaction type N/A PTMCode2
RAD17 RFC5 25361965 interaction type N/A PTMCode2
RFC5 RAD17 25361965 interaction type N/A PTMCode2
RFC2 RFC5 25361965 interaction type N/A PTMCode2
RFC5 RFC2 25361965 interaction type N/A PTMCode2
LIG1 RFC5 25361965 interaction type N/A PTMCode2
RFC5 LIG1 25361965 interaction type N/A PTMCode2
POLD1 RFC5 25361965 interaction type N/A PTMCode2
RFC5 POLD1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
ARID5A RFC5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SNW1 RFC5 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CDC5L RFC5 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TRIM38 RFC5 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TSNAX RFC5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PCNA RFC5 14525934 25348397 8999859 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
VCP RFC5 25348397 N/A physical interaction ComPPI
XIAP RFC5 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
NR5A1 RFC5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KEAP1 RFC5 25348397 N/A physical interaction ComPPI
GTF2B RFC5 25348397 N/A physical interaction ComPPI
EXOSC8 RFC5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DDIT4L RFC5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ZNF426 RFC5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RPL10 RFC5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NFATC1 RFC5 25348397 N/A physical interaction ComPPI
UNC119 RFC5 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
JUN RFC5 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
RB1 RFC5 25348397 N/A physical interaction ComPPI
CUL3 RFC5 25348397 N/A physical interaction ComPPI
UBC RFC5 25348397 N/A physical interaction ComPPI
NTRK1 RFC5 25348397 N/A physical interaction ComPPI
RPA1 RFC5 25348397 N/A physical interaction ComPPI
RFC2 RFC5 14525934 24234451 25348397 8692848 9228079 9488738 physical association two hybrid,cosedimentation in solution,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
CHTF18 RFC5 25348397 N/A physical interaction ComPPI
DSCC1 RFC5 25348397 N/A physical interaction ComPPI
DERPC RFC5 25348397 N/A physical interaction ComPPI
CHTF8 RFC5 25348397 N/A physical interaction ComPPI
MYC RFC5 17314511 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
HNRNPU RFC5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EEF1A1 RFC5 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CFTR RFC5 25348397 N/A physical interaction ComPPI
NFATC2 RFC5 25348397 N/A physical interaction ComPPI
ECT2 RFC5 25348397 N/A physical interaction ComPPI
RPA2 RFC5 25348397 N/A physical interaction ComPPI
RPA3 RFC5 25348397 N/A physical interaction ComPPI
HUWE1 RFC5 25348397 N/A physical interaction ComPPI
EGFR RFC5 25348397 N/A physical interaction ComPPI
PSMC4 RFC5 25348397 N/A physical interaction ComPPI
MMS19 RFC5 25348397 N/A physical interaction ComPPI
GABARAP RFC5 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
CENPJ RFC5 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
MDC1 RFC5 25348397 N/A physical interaction ComPPI
COPS6 RFC5 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
EED RFC5 25348397 N/A physical interaction ComPPI
RBM48 RFC5 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
XAF1 RFC5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
H3C1 RFC5 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CAND1 RFC5 25348397 N/A physical interaction ComPPI
CD40 RFC5 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
LRIF1 RFC5 14525934 16169070 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
RFC5 RFC4 14525934 16189514 24234451 25348397 25416956 30021884 8692848 9228079 9488738 association,physical association two hybrid,cross-linking study,experimental interaction detection,pull down,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,in vitro,in vivo,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
RFC5 MED31 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
RFC5 RAD17 14624239 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
RFC5 EEF1A1P5 25348397 N/A physical interaction ComPPI
RFC5 BRD4 25348397 N/A physical interaction ComPPI
RFC5 RFC1 24234451 25348397 9488738 association,physical association cosedimentation in solution,pull down,physical interaction ComPPI,IntAct
RFC5 RUVBL2 25348397 N/A physical interaction ComPPI
RFC5 RPAP3 25348397 N/A physical interaction ComPPI
RFC5 MEPCE 25348397 N/A physical interaction ComPPI
RFC5 PIDD1 25348397 N/A physical interaction ComPPI
RFC5 SMARCAD1 25348397 N/A physical interaction ComPPI
RFC5 HDGF 21907836 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
RFC5 RFC3 25348397 N/A physical interaction ComPPI
RFC5 MTMR2 25348397 N/A physical interaction ComPPI
RFC5 FBXO6 25348397 N/A physical interaction ComPPI
RFC5 NAB2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
RFC5 CCDC8 25348397 N/A physical interaction ComPPI
RFC5 NMD3 25348397 N/A physical interaction ComPPI
RFC5 OFD1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
RFC5 MKS1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
RFC5 SPICE1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
RFC5 NOP56 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RFC5 ZNF746 25348397 N/A physical interaction ComPPI
RFC5 ATAD5 25348397 N/A physical interaction ComPPI
RFC5 IL13RA2 25348397 N/A physical interaction ComPPI
RFC5 MCM9 25348397 N/A physical interaction ComPPI
RFC5 RIF1 16169070 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
RFC5 TSC22D1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
RFC5 KDM4A 23871696 24234451 25348397 association pull down ComPPI,IntAct
RFC5 RIPK4 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
RFC5 TASOR2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RFC5 ZNF19 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RFC5 CCNC 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RFC5 KRT34 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RFC5 PPP1R16B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RFC5 N4BP3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RFC5 BIRC2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RFC5 RRP1B 20926688 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
RFC5 NBEAL2 24234451 25348397 29187380 association tandem affinity purification ComPPI,IntAct
RFC5 DAPK1 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
HSCB RFC5 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct
ITGB1 RFC5 24234451 30021884 physical association cross-linking study IntAct
RFC5 CAPN12 24234451 30021884 physical association cross-linking study IntAct
RFC5 AKAP9 24234451 30021884 physical association cross-linking study IntAct
RFC5 PIK3R6 24234451 30021884 physical association cross-linking study IntAct
L1TD1 RFC5 24234451 25702638 association anti bait coimmunoprecipitation IntAct

Visualization










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