Gene Information gene info

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GENE：CTPS1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CTPS1
FullNmae CTP synthase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2519
EnsembleID ENSG00000171793
Uniprot P17812

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CTPS1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CTPS1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
CTPS1 GO:0003883,GO:0003883,GO:0003883,GO:0003883,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0006139,GO:0006241,GO:0006241,GO:0006241,GO:0006541,GO:0009410,GO:0016020,GO:0019856,GO:0042098,GO:0042100,GO:0042802,GO:0042802,GO:0044210,GO:0097268,GO:0097268

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CTPS1 hsa:1503 path:hsa00240 Pyrimidine metabolism - Homo sapiens (human)
CTPS1 hsa:1503 path:hsa01100 Metabolic pathways - Homo sapiens (human)
CTPS1 hsa:1503 path:hsa01232 Nucleotide metabolism - Homo sapiens (human)
CTPS1 hsa:1503 path:hsa01240 Biosynthesis of cofactors - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
NFKBIL1 CTPS1 17855452 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 CTPS1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 CTPS1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 CTPS1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 CTPS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA CTPS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CTPS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 CTPS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 CTPS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 CTPS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS CTPS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CTPS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF CTPS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR CTPS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 CTPS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 CTPS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TWIST1 CTPS1 19051271 trascriptional regulation,stimulation inferred by curator TFlink
TWIST2 CTPS1 19051271 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00003380CC CTPS1 17612493 25416803 mrna cleavage,inhibition array technology TarBase
URS0000324096 CTPS1 18668040 23313552 25416803 mrna cleavage,inhibition experimental interaction detection,clip TarBase
URS00003D5391 CTPS1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00005651EE CTPS1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003CF1AD CTPS1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000021D7C8 CTPS1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000239117 CTPS1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000039E1E1 CTPS1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001FFA8C CTPS1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000411752 CTPS1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000C48FA CTPS1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000052E1A6 CTPS1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001383CF CTPS1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000237CBD CTPS1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000032EF64 CTPS1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000122ED0 CTPS1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000000B1C9 CTPS1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000031E12 CTPS1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000029979D CTPS1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000A07C1 CTPS1 23313552 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKACA CTPS1 22135298 phosphorylation N/A PhosphoSite
GSK3A CTPS1 22135298 phosphorylation N/A PhosphoSite
PRKCA CTPS1 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
CUL5 CTPS1 25348397 N/A physical interaction ComPPI
IMPDH2 CTPS1 25348397 N/A physical interaction ComPPI
LCA5 CTPS1 24234451 25348397 26638075 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TRAF6 CTPS1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CLNS1A CTPS1 25348397 N/A physical interaction ComPPI
GABARAPL2 CTPS1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
YWHAG CTPS1 14525934 15324660 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,in vivo ComPPI,HPRD,IntAct
RAD21 CTPS1 25348397 N/A physical interaction ComPPI
KEAP1 CTPS1 25348397 N/A physical interaction ComPPI
MCM2 CTPS1 25348397 N/A physical interaction ComPPI
MAP1LC3B CTPS1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PDCD10 CTPS1 25348397 N/A physical interaction ComPPI
COPS5 CTPS1 25348397 N/A physical interaction ComPPI
CTBP2 CTPS1 25348397 N/A physical interaction ComPPI
PSMA3 CTPS1 25348397 N/A physical interaction ComPPI
CUL3 CTPS1 25348397 N/A physical interaction ComPPI
YWHAB CTPS1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
YWHAZ CTPS1 15161933 24234451 25348397 physical association pull down ComPPI,IntAct
NTRK1 CTPS1 25348397 N/A physical interaction ComPPI
PRMT1 CTPS1 25348397 N/A physical interaction ComPPI
SNX2 CTPS1 25348397 N/A physical interaction ComPPI
MYC CTPS1 17353931 21150319 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
PRMT5 CTPS1 25348397 N/A physical interaction ComPPI
VCL CTPS1 25348397 N/A physical interaction ComPPI
CFTR CTPS1 25348397 N/A physical interaction ComPPI
PKM CTPS1 25348397 N/A physical interaction ComPPI
UBA6 CTPS1 25348397 N/A physical interaction ComPPI
YWHAQ CTPS1 25348397 N/A physical interaction ComPPI
NEDD8 CTPS1 25348397 N/A physical interaction ComPPI
CUL2 CTPS1 25348397 N/A physical interaction ComPPI
CUL4B CTPS1 25348397 N/A physical interaction ComPPI
ARRB2 CTPS1 17620599 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CDK2 CTPS1 25348397 N/A physical interaction ComPPI
CUL1 CTPS1 25348397 N/A physical interaction ComPPI
PINX1 CTPS1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
MTREX CTPS1 25348397 N/A physical interaction ComPPI
GABARAP CTPS1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
STRAP CTPS1 25348397 N/A physical interaction ComPPI
MAP1LC3A CTPS1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
TUBGCP3 CTPS1 25348397 N/A physical interaction ComPPI
AURKA CTPS1 25348397 N/A physical interaction ComPPI
CAND1 CTPS1 25348397 N/A physical interaction ComPPI
UBA1 CTPS1 25348397 N/A physical interaction ComPPI
TRIM25 CTPS1 25348397 N/A physical interaction ComPPI
DFFA CTPS1 25348397 N/A physical interaction ComPPI
EIF4B CTPS1 25348397 N/A physical interaction ComPPI
PPP5C CTPS1 25348397 N/A physical interaction ComPPI
SNU13 CTPS1 25348397 N/A physical interaction ComPPI
BRCA1 CTPS1 25348397 N/A physical interaction ComPPI
PPEF1 CTPS1 24234451 25348397 28330616 association pull down ComPPI,IntAct
NMD3 CTPS1 25348397 N/A physical interaction ComPPI
PRKAB1 CTPS1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TSN CTPS1 25348397 N/A physical interaction ComPPI
IKBKE CTPS1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
BCAR3 CTPS1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ERCC2 CTPS1 25348397 N/A physical interaction ComPPI
HSD17B10 CTPS1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
CS CTPS1 25348397 N/A physical interaction ComPPI
CYLD CTPS1 25348397 N/A physical interaction ComPPI
PAPSS1 CTPS1 25348397 N/A physical interaction ComPPI
CTPS2 CTPS1 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GABARAPL1 CTPS1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
DCTPP1 CTPS1 25348397 N/A physical interaction ComPPI
CTPS1 FBXO6 25348397 N/A physical interaction ComPPI
CTPS1 RBM28 25348397 N/A physical interaction ComPPI
CTPS1 POLR1C 25348397 N/A physical interaction ComPPI
CTPS1 ACO1 25348397 N/A physical interaction ComPPI
CTPS1 UBXN1 25348397 N/A physical interaction ComPPI
CTPS1 GINS3 25348397 N/A physical interaction ComPPI
CTPS1 GMPS 25348397 N/A physical interaction ComPPI
CTPS1 IMPDH1 25348397 N/A physical interaction ComPPI
CTPS1 PLCG1 25348397 N/A physical interaction ComPPI
CTPS1 RTF2 25348397 N/A physical interaction ComPPI
CTPS1 TRMT1 25348397 N/A physical interaction ComPPI
CTPS1 TTC4 25348397 N/A physical interaction ComPPI
CTPS1 WDR36 25348397 N/A physical interaction ComPPI
CTPS1 PUS7 25348397 N/A physical interaction ComPPI
CTPS1 OFD1 24234451 25348397 26638075 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CTPS1 RPGRIP1L 24234451 25348397 26638075 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CTPS1 SNX3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CTPS1 OTUB1 24234451 25348397 26752685 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CTPS1 TIGD3 25348397 N/A physical interaction ComPPI
CTPS1 FAM107A 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CTPS1 HLA-C 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CTPS1 HLA-B 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CTPS1 RNF169 21252943 24234451 25348397 association pull down ComPPI,IntAct
CTPS1 PTBP3 22575643 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
CTPS1 CTPS1 24234451 25416956 physical association two hybrid array,two hybrid prey pooling approach IntAct
H2AC14 CTPS1 24234451 30021884 physical association cross-linking study IntAct
PRKACA CTPS1 17189248 17463002 27898060 N/A N/A OmniPath
PRKCA CTPS1 17463002 27898060 inhibition,stimulant N/A OmniPath
GSK3A CTPS1 17681942 27898060 N/A N/A OmniPath
PAK1 CTPS1 17189248 17463002 17681942 27898060 N/A N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00008BA695 CTPS1 27087310 direct interaction,inhibition N/A NPInter

Visualization










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