Gene Information gene info

  1. Home

GENE：PIAS4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PIAS4
FullNmae protein inhibitor of activated STAT 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:17002
EnsembleID ENSG00000105229
Uniprot Q8N2W9

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PIAS4 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PIAS4 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PIAS4 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PIAS4 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
PIAS4 GO:0000122,GO:0001942,GO:0003677,GO:0003712,GO:0003714,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005737,GO:0006302,GO:0006357,GO:0007417,GO:0008270,GO:0010804,GO:0016055,GO:0016363,GO:0016605,GO:0016925,GO:0016925,GO:0016925,GO:0016925,GO:0016925,GO:0019789,GO:0019789,GO:0019789,GO:0031625,GO:0033235,GO:0042359,GO:0045892,GO:0045892,GO:0060887,GO:0061665,GO:0061665,GO:0120186,GO:1902174,GO:1902231,GO:1905168,GO:1990234

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PIAS4 hsa:51588 path:hsa04064 NF-kappa B signaling pathway - Homo sapiens (human)
PIAS4 hsa:51588 path:hsa04120 Ubiquitin mediated proteolysis - Homo sapiens (human)
PIAS4 hsa:51588 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
PIAS4 hsa:51588 path:hsa05418 Fluid shear stress and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PIAS4 IRF3 15251447 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF7 PIAS4 15251447 23180781 physical association anti tag coimmunoprecipitation InnateDB
PIAS4 TICAM1 15251447 23180781 physical association anti tag coimmunoprecipitation InnateDB
PIAS4 GFI1 19506020 23180781 physical association two hybrid InnateDB
PHF11 PIAS4 21988832 23180781 physical association two hybrid array InnateDB
PIAS4 STAT1 11248056 23331499 stimulation N/A SignaLink
PIAS4 SMAD3 12904571 23331499 stimulation N/A SignaLink
PIAS4 SMAD4 12904571 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
GADD45G PIAS4 20005715 interaction type N/A PSP
HTT PIAS4 15383276 20005715 21071413 interaction type N/A PSP,SignaLink
SNIP1 PIAS4 20005715 interaction type N/A PSP
SNIP1 PIAS4 20005715 N/A N/A SignaLink
GADD45G PIAS4 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 PIAS4 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 PIAS4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 PIAS4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PIAS4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PIAS4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PIAS4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 PIAS4 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000005481D PIAS4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002367FA PIAS4 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000018D2BE PIAS4 20371350 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000331800 PIAS4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000005CE28 PIAS4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000EEF5F PIAS4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000001C659 PIAS4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004929F1 PIAS4 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00002373FD PIAS4 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00000EC1BE PIAS4 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000035D2F9 PIAS4 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000055929F PIAS4 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00002C83DA PIAS4 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000149319 PIAS4 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKCZ PIAS4 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
PDE4DIP PIAS4 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PIAS2 PIAS4 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
KRT18 PIAS4 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
UBE2I PIAS4 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TRIM38 PIAS4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HNRNPC PIAS4 25348397 N/A two hybrid ComPPI
GADD45G PIAS4 14525934 15383276 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
FTH1 PIAS4 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VIM PIAS4 14525934 15383276 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
IMPDH2 PIAS4 14525934 15383276 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SKIL PIAS4 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
COIL PIAS4 14525934 16219678 25348397 27898060 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
TP53BP1 PIAS4 25348397 N/A physical interaction ComPPI
TRIM32 PIAS4 25348397 N/A physical interaction ComPPI
SMAD4 PIAS4 12904571 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
ZNF512B PIAS4 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SNIP1 PIAS4 14525934 15231748 24234451 25348397 physical association two hybrid,two hybrid ComPPI,HPRD,IntAct
OPTN PIAS4 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAGEH1 PIAS4 14525934 15383276 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD1 PIAS4 12904571 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
ERBB4 PIAS4 25348397 N/A physical interaction ComPPI
SMAD7 PIAS4 12815042 14525934 15231748 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
SETDB1 PIAS4 14525934 15383276 25348397 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
PDE4A PIAS4 25348397 N/A physical interaction ComPPI
AR PIAS4 11439351 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SMAD2 PIAS4 12904571 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
SUMO1 PIAS4 16524884 21199872 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SMAD3 PIAS4 12904571 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
HIF1A PIAS4 20661221 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
PIAS1 PIAS4 11877418 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
MECOM PIAS4 25348397 N/A physical interaction ComPPI
EIF5B PIAS4 25348397 N/A physical interaction ComPPI
TGM2 PIAS4 25348397 N/A physical interaction ComPPI
OAZ1 PIAS4 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
KPNB1 PIAS4 14525934 15383276 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
ACTN1 PIAS4 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PRPF40A PIAS4 14525934 15383276 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SERPINA5 PIAS4 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
IRF3 PIAS4 14525934 15251447 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
PARP1 PIAS4 19779455 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
XRCC5 PIAS4 19779455 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
CLK1 PIAS4 14525934 15383276 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
XRCC6 PIAS4 19779455 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
PRMT5 PIAS4 19779455 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
HNRNPL PIAS4 25348397 N/A physical interaction ComPPI
PRKCZ PIAS4 25348397 N/A physical interaction ComPPI
PDE4D PIAS4 25348397 N/A physical interaction ComPPI
RELA PIAS4 17606919 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FANCD2 PIAS4 25348397 N/A physical interaction ComPPI
NR4A2 PIAS4 14525934 14559918 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
TADA3 PIAS4 14525934 15383276 24234451 25348397 physical association two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
SUMO2 PIAS4 14525934 15383276 24234451 25348397 physical association two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
SUMO3 PIAS4 14525934 15383276 24234451 25348397 physical association two hybrid,two hybrid ComPPI,HPRD,IntAct
HTT PIAS4 14525934 15383276 24234451 25348397 physical association two hybrid,experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
VHL PIAS4 20300531 20844582 24002598 25348397 27898060 N/A physical interaction ComPPI,OmniPath
HDAC2 PIAS4 25348397 N/A physical interaction ComPPI
ZHX1 PIAS4 14525934 15383276 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
MAP1LC3A PIAS4 14525934 15383276 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
HNF4A PIAS4 25348397 N/A physical interaction ComPPI
UBE2K PIAS4 14525934 15383276 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
PIAS4 IMMT 14525934 15383276 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
PIAS4 BARD1 14525934 15383276 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
PIAS4 TCERG1 14525934 15383276 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
PIAS4 RIF1 14525934 15383276 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
PIAS4 TICAM1 14525934 15251447 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
PIAS4 CALCOCO2 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PIAS4 IRF7 14525934 15251447 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
PIAS4 PTN 14525934 15383276 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
PIAS4 LEF1 11731474 14525934 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
PIAS4 SMAD6 25348397 N/A physical interaction ComPPI
PIAS4 ETS1 16862185 17456046 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PIAS4 ZMIZ2 25348397 N/A physical interaction ComPPI
PIAS4 BRCA1 25348397 N/A physical interaction ComPPI
PIAS4 TCF4 25348397 N/A physical interaction ComPPI
PIAS4 CEBPD 25348397 N/A physical interaction ComPPI
PIAS4 TRIM27 25348397 N/A physical interaction ComPPI
PIAS4 HDAC1 12904571 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
PIAS4 SATB1 18408014 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PIAS4 CAPN8 25348397 N/A physical interaction ComPPI
PIAS4 KNTC1 25348397 N/A physical interaction ComPPI
PIAS4 ZW10 25348397 N/A physical interaction ComPPI
PIAS4 HERC2 25348397 N/A physical interaction ComPPI
PIAS4 HERC2P3 25348397 N/A physical interaction ComPPI
PIAS4 MDC1 25348397 N/A physical interaction ComPPI
PIAS4 ELAVL1 25348397 N/A physical interaction ComPPI
PIAS4 IKBKG 25348397 N/A physical interaction ComPPI
PIAS4 CHD3 14525934 15383276 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
PIAS4 LRIF1 15383276 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PIAS4 SH3GL3 25348397 N/A physical interaction ComPPI
PIAS4 TP53 11388671 14525934 15383276 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD,IntAct,OmniPath
PIAS4 SERBP1 25348397 N/A physical interaction ComPPI
PIAS4 PLAG1 25348397 N/A physical interaction ComPPI
PIAS4 PHGDH 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PIAS4 IL15RA 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PIAS4 PHF11 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PIAS4 ALDOA 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PIAS4 ESRRA 18063693 21988832 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
PIAS4 LAMP2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PIAS4 BTAF1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PIAS4 HNRNPUL1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PIAS4 MPRIP 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PIAS4 HIC1 25348397 N/A physical interaction ComPPI
PIAS4 TOP2A 25348397 N/A physical interaction ComPPI
PIAS4 CA10 25348397 N/A physical interaction ComPPI
PIAS4 REV1 25348397 N/A physical interaction ComPPI
PIAS4 AREL1 25348397 N/A physical interaction ComPPI
PIAS4 FANCA 25348397 N/A physical interaction ComPPI
PIAS4 FANCI 25348397 N/A physical interaction ComPPI
PIAS4 MEN1 19779455 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
PIAS4 GFI1 17636019 24234451 25348397 physical association two hybrid ComPPI,IntAct
PIAS4 LCE1D 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
NEFL PIAS4 14525934 15383276 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
TICAM1 PIAS4 15251447 27898060 N/A N/A OmniPath
GFI1 PIAS4 17636019 19506020 27898060 N/A N/A OmniPath
PIAS4 IKBKG 16906147 18583959 19917246 20301198 20932475 24457965 25735744 27898060 stimulant N/A OmniPath
PIAS4 STAT1 11248056 27898060 inhibition,stimulant N/A OmniPath
PIAS4 IRF3 15251447 27898060 inhibition N/A OmniPath
PIAS4 TP53BP1 20016603 27898060 stimulant N/A OmniPath
PIAS4 RPA2 20016603 27898060 stimulant N/A OmniPath
IRF7 PIAS4 15251447 27898060 N/A N/A OmniPath
PIAS4 SMAD4 12740389 12815042 12904571 27898060 inhibition,stimulant N/A OmniPath
PARP1 PIAS4 19779455 20696768 20932475 27898060 stimulant N/A OmniPath
PIAS4 SMAD3 12815042 12904571 27898060 inhibition,stimulant N/A OmniPath
PHF11 PIAS4 21988832 27898060 N/A N/A OmniPath
PIAS4 NR4A2 14559918 27898060 N/A N/A OmniPath

Visualization










  Return