GENE：CNKSR1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | CNKSR1 |
| FullNmae | connector enhancer of kinase suppressor of Ras 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:19700 |
| EnsembleID | ENSG00000142675 |
| Uniprot | Q969H4 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| CNKSR1 | pyroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CNKSR1 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| CNKSR1 | GO:0005515,GO:0005886,GO:0005911,GO:0005938,GO:0007169,GO:0030674 |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CNKSR1 | RHOD | 20005715 | interaction type | N/A | PSP |
| CNKSR1 | MAP2K7 | 20005715 | interaction type | N/A | PSP,SignaLink |
| CNKSR1 | RAF1 | 20005715 | interaction type | N/A | PSP,SignaLink |
| CNKSR1 | RHOC | 20005715 | interaction type | N/A | PSP,SignaLink |
| CNKSR1 | RHOA | 20005715 | interaction type | N/A | PSP,SignaLink |
| CNKSR1 | MAP3K10 | 20005715 | interaction type | N/A | PSP,SignaLink |
| CNKSR1 | STK4 | 20005715 | interaction type | N/A | PSP,SignaLink |
| CNKSR1 | STK3 | 20005715 | interaction type | N/A | PSP,SignaLink |
| CNKSR1 | RHOD | 14749388 14749388 20005715 20005715 21071413 | N/A | N/A | SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GATA1 | CNKSR1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | CNKSR1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| CEBPA | CNKSR1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | CNKSR1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | CNKSR1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | CNKSR1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SRC | CNKSR1 | 22135298 | phosphorylation | N/A | PhosphoSite |
| RASSF1 | CNKSR1 | 25361965 | interaction type | N/A | PTMCode2 |
| CNKSR1 | RASSF1 | 25361965 | interaction type | N/A | PTMCode2 |
| RAF1 | CNKSR1 | 25361965 | interaction type | N/A | PTMCode2 |
| CNKSR1 | RAF1 | 25361965 | interaction type | N/A | PTMCode2 |
| RHPN1 | CNKSR1 | 25361965 | interaction type | N/A | PTMCode2 |
| CNKSR1 | RHPN1 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PIN1 | CNKSR1 | 24234451 25348397 25416956 | physical association | physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
| SMAD4 | CNKSR1 | 15231748 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| RHOC | CNKSR1 | 15670823 24234451 25348397 | physical association | bioluminescence resonance energy transfer | ComPPI,IntAct |
| RHOA | CNKSR1 | 15670823 24234451 25348397 | physical association | anti tag coimmunoprecipitation,bioluminescence resonance energy transfer,physical interaction | ComPPI,IntAct |
| RHPN1 | CNKSR1 | 25348397 | N/A | physical interaction | ComPPI |
| CYTH2 | CNKSR1 | 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| CYTH1 | CNKSR1 | 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| TRIM24 | CNKSR1 | 25348397 | N/A | physical interaction | ComPPI |
| BRCA2 | CNKSR1 | 25348397 | N/A | physical interaction | ComPPI |
| ZDHHC17 | CNKSR1 | 24234451 24705354 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| RAF1 | CNKSR1 | 25348397 | N/A | physical interaction | ComPPI |
| RASSF1 | CNKSR1 | 25348397 | N/A | physical interaction | ComPPI |
| STK4 | CNKSR1 | 25348397 | N/A | physical interaction | ComPPI |
| RHOH | CNKSR1 | 15670823 24234451 25348397 | physical association | bioluminescence resonance energy transfer | ComPPI,IntAct |
| STK3 | CNKSR1 | 25348397 | N/A | physical interaction | ComPPI |
| ASPM | CNKSR1 | 25348397 | N/A | physical interaction | ComPPI |
| TRIM33 | CNKSR1 | 25348397 | N/A | physical interaction | ComPPI |
| CYTH3 | CNKSR1 | 16189514 24234451 25348397 25416956 | physical association | physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
| RALGDS | CNKSR1 | 25348397 | N/A | physical interaction | ComPPI |
| CNKSR1 | CYTH4 | 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| CNKSR1 | HAUS5 | 25348397 | N/A | physical interaction | ComPPI |
| CNKSR1 | PHLDB3 | 25348397 | N/A | physical interaction | ComPPI |
| SRC | CNKSR1 | 24825906 26319181 27898060 | N/A | N/A | OmniPath |
| CNKSR1 | RAF1 | 15075335 15845549 27898060 9115393 | stimulant | N/A | OmniPath |
| CNKSR1 | RASSF1 | 15075335 22830020 27898060 | stimulant | N/A | OmniPath |