Gene Information gene info

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GENE：DHFR

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol DHFR
FullNmae dihydrofolate reductase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2861
EnsembleID ENSG00000228716
Uniprot P00374

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
DHFR mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
DHFR autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
DHFR GO:0000900,GO:0003729,GO:0004146,GO:0004146,GO:0004146,GO:0004146,GO:0005542,GO:0005739,GO:0005739,GO:0005829,GO:0006545,GO:0006729,GO:0006729,GO:0006730,GO:0017148,GO:0031103,GO:0031427,GO:0046452,GO:0046452,GO:0046653,GO:0046654,GO:0046654,GO:0046654,GO:0046655,GO:0046655,GO:0050661,GO:0051000,GO:0070402,GO:1990825,GO:2000121

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
DHFR hsa:1719 path:hsa00670 One carbon pool by folate - Homo sapiens (human)
DHFR hsa:1719 path:hsa00790 Folate biosynthesis - Homo sapiens (human)
DHFR hsa:1719 path:hsa01100 Metabolic pathways - Homo sapiens (human)
DHFR hsa:1719 path:hsa01240 Biosynthesis of cofactors - Homo sapiens (human)
DHFR hsa:1719 path:hsa01523 Antifolate resistance - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TP53 DHFR 16738336 23180781 physical association anti tag coimmunoprecipitation InnateDB
NFYA DHFR 16738336 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 DHFR 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SP1 DHFR 1834700 trascriptional regulation,stimulation electrophoretic mobility shift assay TFlink
E2F4 DHFR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A DHFR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
IGF1R DHFR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 DHFR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 DHFR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 DHFR 14618416 trascriptional regulation,stimulation inferred by curator TFlink
RB1 DHFR 9671466 trascriptional regulation,stimulation inferred by curator TFlink
TFDP1 DHFR 14618416 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000B59A2 DHFR 25416803 26506238 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS000033EBB8 DHFR 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000DDD35 DHFR 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000F6E49 DHFR 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001C308D DHFR 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000041CB9C DHFR 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000C85B2 DHFR 25416803 28188287 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
HSPD1 DHFR 25361965 interaction type N/A PTMCode2
DHFR HSPD1 25361965 interaction type N/A PTMCode2
THBS1 DHFR 25361965 interaction type N/A PTMCode2
DHFR THBS1 25361965 interaction type N/A PTMCode2
TOMM20 DHFR 25361965 interaction type N/A PTMCode2
DHFR TOMM20 25361965 interaction type N/A PTMCode2
DHFR DHFR 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
FOXB1 DHFR 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
FKBP1A DHFR 12812497 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
UBC DHFR 25348397 N/A physical interaction ComPPI
THBS1 DHFR 10749676 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
MDM2 DHFR 14525934 18451149 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
EGFR DHFR 25348397 N/A physical interaction ComPPI
DHFR HSPD1 14525934 25348397 27898060 8559246 8976559 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
DHFR TOMM20 14525934 25348397 9119086 N/A experimental interaction detection,in vitro ComPPI,HPRD
DHFR TP53 14525934 18451149 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
DHFR AMFR 25348397 N/A physical interaction ComPPI
DHFR GKAP1 25348397 N/A physical interaction ComPPI
DHFR FOXL1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
DHFR TRIM25 25348397 N/A physical interaction ComPPI
DHFR AIFM1 24234451 25348397 29568061 association pull down ComPPI,IntAct
HSCB DHFR 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct
DHFR ASGR1 14525934 1935897 27898060 N/A experimental interaction detection HPRD,OmniPath
TRAF2 DHFR 24234451 30561431 association virotrap IntAct
RBCK1 DHFR 24234451 30561431 association virotrap IntAct
SHARPIN DHFR 24234451 30561431 association virotrap IntAct
TNIP2 DHFR 24234451 30561431 association virotrap IntAct
DHFR TP53 16738336 18451149 27898060 N/A N/A OmniPath

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