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GENE：POLA2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol POLA2
FullNmae DNA polymerase alpha 2, accessory subunit
LocusType gene with protein product
Status Approved
HGNC_id HGNC:30073
EnsembleID ENSG00000014138
Uniprot Q14181

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
POLA2 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
POLA2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
POLA2 GO:0003674,GO:0003677,GO:0005515,GO:0005654,GO:0005654,GO:0005658,GO:0005658,GO:0005658,GO:0005829,GO:0006260,GO:0006269,GO:0006270,GO:0006270,GO:0006606

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
POLA2 hsa:23649 path:hsa03030 DNA replication - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR POLA2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 POLA2 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 POLA2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 POLA2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 POLA2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 POLA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA POLA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF POLA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 POLA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 POLA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS POLA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A POLA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 POLA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
JUN POLA2 N/A trascriptional regulation,stimulation inferred by curator TFlink
MYB POLA2 N/A trascriptional regulation,stimulation inferred by curator TFlink
NFIC POLA2 N/A trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A POLA2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000F31F4 POLA2 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 POLA2 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00001FC26E POLA2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000C5969 POLA2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005C1F22 POLA2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000027464B POLA2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002C28B2 POLA2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000016E46F POLA2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001C04A2 POLA2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000122ED0 POLA2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002F8148 POLA2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000324096 POLA2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004F4657 POLA2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000031F6C2 POLA2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000A9FB9 POLA2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001FFA8C POLA2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075D814 POLA2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075CC78 POLA2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001012BC POLA2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005586D0 POLA2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000008B558 POLA2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000021202F POLA2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000AF45F POLA2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001F373E POLA2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000272A92 POLA2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004977C5 POLA2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005194EC POLA2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000029EBD POLA2 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CIAO1 POLA2 25348397 N/A physical interaction ComPPI
POP7 POLA2 25348397 N/A physical interaction ComPPI
RAC1 POLA2 25348397 N/A physical interaction ComPPI
EZH2 POLA2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
SETDB1 POLA2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
POLA1 POLA2 12138179 14525934 24234451 25348397 8223465 association affinity chromatography technology,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
ITGB3BP POLA2 16169070 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
PARP1 POLA2 25348397 N/A physical interaction ComPPI
POLD2 POLA2 25348397 N/A physical interaction ComPPI
MPZL1 POLA2 25348397 N/A physical interaction ComPPI
EIF6 POLA2 14525934 16169070 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
CHM POLA2 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
XPO1 POLA2 25348397 N/A physical interaction ComPPI
HELB POLA2 12181327 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
EPB41L1 POLA2 25348397 N/A physical interaction ComPPI
FGFR3 POLA2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
NR4A1 POLA2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
KLF6 POLA2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
MMS19 POLA2 25348397 N/A physical interaction ComPPI
HDAC6 POLA2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PRIM1 POLA2 12138179 24234451 25348397 association affinity chromatography technology,physical interaction ComPPI,IntAct
CDK8 POLA2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
RAE1 POLA2 25348397 N/A physical interaction ComPPI
SNU13 POLA2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
SSH3 POLA2 25348397 N/A physical interaction ComPPI
DCP2 POLA2 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
CAPN1 POLA2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HEXIM1 POLA2 25348397 N/A physical interaction ComPPI
UBE2O POLA2 25348397 N/A physical interaction ComPPI
ARPC5 POLA2 25348397 N/A physical interaction ComPPI
CPE POLA2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
IGFBP3 POLA2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
AKTIP POLA2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
SCYL1 POLA2 25348397 N/A physical interaction ComPPI
POLA2 ATP5F1C 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
POLA2 DDX24 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
POLA2 LRPAP1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
POLA2 STK40 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
POLA2 RBM23 14525934 16169070 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
POLA2 ULK2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
POLA2 KCNE3 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
POLA2 FRZB 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
POLA2 APP 25348397 N/A physical interaction ComPPI
POLA2 PRIM2 12138179 24234451 25348397 association affinity chromatography technology,physical interaction ComPPI,IntAct
POLA2 REPIN1 25348397 N/A physical interaction ComPPI
POLA2 POU5F1 25348397 N/A physical interaction ComPPI
POLA2 TKT 25348397 N/A physical interaction ComPPI
POLA2 LGALS7 25348397 N/A physical interaction ComPPI
PRPF38A POLA2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct

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