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GENE：LSM2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol LSM2
FullNmae LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
LocusType gene with protein product
Status Approved
HGNC_id HGNC:13940
EnsembleID ENSG00000204392
Uniprot Q9Y333

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
LSM2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
LSM2 GO:0000244,GO:0000398,GO:0000398,GO:0000398,GO:0000398,GO:0000932,GO:0003723,GO:0003723,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005688,GO:0005737,GO:0005829,GO:0006402,GO:0017070,GO:0031267,GO:0046540,GO:0046540,GO:0046540,GO:0071005,GO:0071011,GO:0071013,GO:0071013,GO:0120115,GO:1990726

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
LSM2 hsa:57819 path:hsa03018 RNA degradation - Homo sapiens (human)
LSM2 hsa:57819 path:hsa03040 Spliceosome - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ZNF143 LSM2 17938208 23180781 physical association anti tag coimmunoprecipitation InnateDB
BRF2 LSM2 17938208 23180781 physical association anti tag coimmunoprecipitation InnateDB
CHD8 LSM2 17938208 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLE5 LSM2 23180781 25416956 physical association two hybrid InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 LSM2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 LSM2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
CTCF LSM2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 LSM2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 LSM2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A LSM2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF LSM2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 LSM2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 LSM2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000512C88 LSM2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001C770D LSM2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00005F1B8C LSM2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001A6D0C LSM2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000015A0D9 LSM2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002578DA LSM2 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
TXNL4A LSM2 25361965 interaction type N/A PTMCode2
LSM2 TXNL4A 25361965 interaction type N/A PTMCode2
SNRPD1 LSM2 25361965 interaction type N/A PTMCode2
LSM2 SNRPD1 25361965 interaction type N/A PTMCode2
SNRPD2 LSM2 25361965 interaction type N/A PTMCode2
LSM2 SNRPD2 25361965 interaction type N/A PTMCode2
LSM6 LSM2 25361965 interaction type N/A PTMCode2
LSM2 LSM6 25361965 interaction type N/A PTMCode2
SNRPE LSM2 25361965 interaction type N/A PTMCode2
LSM2 SNRPE 25361965 interaction type N/A PTMCode2
XRN1 LSM2 25361965 interaction type N/A PTMCode2
LSM2 XRN1 25361965 interaction type N/A PTMCode2
LSM8 LSM2 25361965 interaction type N/A PTMCode2
LSM2 LSM8 25361965 interaction type N/A PTMCode2
PRPF4 LSM2 25361965 interaction type N/A PTMCode2
LSM2 PRPF4 25361965 interaction type N/A PTMCode2
USP15 LSM2 25361965 interaction type N/A PTMCode2
LSM2 USP15 25361965 interaction type N/A PTMCode2
LSM7 LSM2 25361965 interaction type N/A PTMCode2
LSM2 LSM7 25361965 interaction type N/A PTMCode2
LSM3 LSM2 25361965 interaction type N/A PTMCode2
LSM2 LSM3 25361965 interaction type N/A PTMCode2
LSM1 LSM2 25361965 interaction type N/A PTMCode2
LSM2 LSM1 25361965 interaction type N/A PTMCode2
USP4 LSM2 25361965 interaction type N/A PTMCode2
LSM2 USP4 25361965 interaction type N/A PTMCode2
SNRPD3 LSM2 25361965 interaction type N/A PTMCode2
LSM2 SNRPD3 25361965 interaction type N/A PTMCode2
EXOSC10 LSM2 25361965 interaction type N/A PTMCode2
LSM2 EXOSC10 25361965 interaction type N/A PTMCode2
LSM2 LSM5 25361965 interaction type N/A PTMCode2
LSM5 LSM2 25361965 interaction type N/A PTMCode2
CRNKL1 LSM2 25361965 interaction type N/A PTMCode2
LSM2 CRNKL1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
ZNF408 LSM2 14525934 14667819 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SNRPB LSM2 22365833 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ZMAT2 LSM2 25348397 N/A physical interaction ComPPI
CBX8 LSM2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SNRPA1 LSM2 25348397 N/A physical interaction ComPPI
LSM2 MAGEA6 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
LSM2 MEOX2 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
LSM2 CLNS1A 22365833 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
LSM2 LSM3 11920408 14525934 14667819 15231747 16169070 16189514 19628699 21516116 22365833 24234451 25348397 25416956 27107012 29997244 physical association anti tag coimmunoprecipitation,bioluminescence resonance energy transfer,two hybrid,experimental interaction detection,molecular sieving,physical interaction,ion exchange chromatography,mammalian protein protein interaction trap,two hybrid array,two hybrid pooling approach,in vitro,luminescence based mammalian interactome mapping,two hybrid prey pooling approach,split luciferase complementation,validated two hybrid,barcode fusion genetics two hybrid,two hybrid ComPPI,HPRD,IntAct
LSM2 SMN1 10851237 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
LSM2 SNRPD2 14525934 14667819 15231747 22365833 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
LSM2 DNAJA1 14525934 14667819 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
LSM2 LSM1 11920408 14525934 15231747 19628699 24234451 25348397 physical association two hybrid,experimental interaction detection,molecular sieving,physical interaction,ion exchange chromatography,two hybrid array,in vitro,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
LSM2 LSM5 11920408 14525934 19628699 24234451 25348397 physical association experimental interaction detection,molecular sieving,physical interaction,ion exchange chromatography,in vitro ComPPI,HPRD,IntAct
LSM2 LSM7 11920408 14525934 14667819 15231747 19628699 22365833 24234451 25348397 physical association two hybrid,experimental interaction detection,molecular sieving,physical interaction,ion exchange chromatography,two hybrid array,in vitro,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
LSM2 LSM8 11920408 14525934 14667819 15231747 19628699 22365833 24234451 25348397 physical association two hybrid,experimental interaction detection,molecular sieving,physical interaction,ion exchange chromatography,in vitro,two hybrid ComPPI,HPRD,IntAct
LSM2 EXOSC10 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
LSM2 CRMP1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
LSM2 ERG28 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
LSM2 RSRC1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
LSM2 GBP2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
LSM2 ZBTB16 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
LSM2 SNRPE 14525934 14667819 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
LSM2 DDX20 25348397 N/A physical interaction ComPPI
LSM2 USP15 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LSM2 USP4 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LSM2 PRPF4 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LSM2 SART3 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LSM2 MEPCE 25348397 N/A physical interaction ComPPI
LSM2 EMD 25348397 N/A physical interaction ComPPI
LSM2 SNRPD1 25348397 N/A physical interaction ComPPI
LSM2 DHX38 25348397 N/A physical interaction ComPPI
LSM2 RBM8A 25348397 N/A physical interaction ComPPI
LSM2 DHX16 25348397 N/A physical interaction ComPPI
LSM2 ILF3 25348397 N/A physical interaction ComPPI
LSM2 TRIM56 25348397 N/A physical interaction ComPPI
LSM2 PYROXD1 25348397 N/A physical interaction ComPPI
LSM2 DKC1 25348397 N/A physical interaction ComPPI
LSM2 SF3B2 22365833 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
LSM2 PRCC 22365833 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
LSM2 SOX2 25348397 N/A physical interaction ComPPI
LSM2 RAB1C 25348397 N/A physical interaction ComPPI
LSM2 RAB1B 25348397 N/A physical interaction ComPPI
LSM2 RALA 25348397 N/A physical interaction ComPPI
LSM2 TLE5 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
LSM2 KRT13 25348397 N/A physical interaction ComPPI
LSM2 REL 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
LSM2 BANP 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
LSM2 TRIM54 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
LSM2 LNX1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
LSM2 BUD31 25348397 N/A physical interaction ComPPI
LSM2 CORO1B 25348397 N/A physical interaction ComPPI
LSM2 CWC27 25348397 N/A physical interaction ComPPI
LSM2 DDB1 25348397 N/A physical interaction ComPPI
LSM2 KDM5C 25348397 N/A physical interaction ComPPI
LSM2 KIF5B 25348397 N/A physical interaction ComPPI
LSM2 PKN2 25348397 N/A physical interaction ComPPI
LSM2 SNRPD3 25348397 N/A physical interaction ComPPI
LSM2 SNX1 25348397 N/A physical interaction ComPPI
LSM2 NAA38 25348397 N/A physical interaction ComPPI
LSM2 PRPF3 25348397 N/A physical interaction ComPPI
LSM2 SNRPF 25348397 N/A physical interaction ComPPI
LSM2 SNRPN 25348397 N/A physical interaction ComPPI
LSM2 NME2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
LSM2 GABARAPL1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
LSM2 GABARAP 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
LSM2 PTBP3 22575643 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
LSM2 PNMA1 24234451 25348397 27107012 physical association validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
LSM2 LGALS7 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LSM2 PATL1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LSM2 MAGEA3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LSM2 LZTS1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LSM2 DDIT4L 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LSM6 LSM2 11920408 14525934 19628699 22365833 24234451 25348397 physical association two hybrid,experimental interaction detection,molecular sieving,physical interaction,ion exchange chromatography,two hybrid array,in vitro,two hybrid prey pooling approach ComPPI,HPRD,IntAct
RNH1 LSM2 25348397 N/A physical interaction ComPPI
LSM4 LSM2 19628699 24234451 25348397 physical association molecular sieving,physical interaction,ion exchange chromatography ComPPI,IntAct
MKI67 LSM2 24234451 26949251 association anti tag coimmunoprecipitation IntAct

Visualization










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