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GENE：SIK3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SIK3
FullNmae SIK family kinase 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:29165
EnsembleID ENSG00000160584
Uniprot Q9Y2K2

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SIK3 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SIK3 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
SIK3 GO:0000226,GO:0000287,GO:0004674,GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0006468,GO:0035556,GO:0050321,GO:0106310,GO:1904263,GO:1904515

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SMAD2 SIK3 18729074 23180781 physical association tandem affinity purification InnateDB
SMAD3 SIK3 18729074 23180781 physical association tandem affinity purification InnateDB

Source Target Pmid Interactiontype Methods Database
AR SIK3 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA1 SIK3 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 SIK3 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 SIK3 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 SIK3 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 SIK3 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 SIK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SIK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SIK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 SIK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SIK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 SIK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 SIK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS SIK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SIK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF SIK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 SIK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 SIK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000031602A SIK3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002E0524 SIK3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000EEE35 SIK3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000039A052 SIK3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004719AB SIK3 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001EFEC1 SIK3 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000285DCB SIK3 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002F5FEE SIK3 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000202460 SIK3 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002233F4 SIK3 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002A71AD SIK3 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000085F64 SIK3 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000076B539 SIK3 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000427B68 SIK3 21572407 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
STK11 SIK3 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
EGLN3 SIK3 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
YWHAQ SIK3 25348397 N/A physical interaction ComPPI
SIK3 YWHAZ 16306228 24234451 25348397 association pull down,physical interaction,in vitro,in vivo,tandem affinity purification ComPPI,IntAct
SIK3 CRTC2 16306228 24234451 25348397 phosphorylation reaction protein kinase assay,in vitro,in vivo ComPPI,IntAct
SIK3 PRKACA 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
SIK3 PRKAA1 25348397 N/A physical interaction ComPPI
SIK3 ELAVL1 25348397 N/A physical interaction ComPPI
SIK3 SMAD2 25348397 N/A physical interaction ComPPI
SIK3 SMAD3 25348397 N/A physical interaction ComPPI
SIK3 TAB2 25348397 N/A physical interaction ComPPI
SIK3 MAP3K7 25348397 N/A physical interaction ComPPI
SIK3 HDAC5 25348397 N/A physical interaction ComPPI
SIK3 YWHAE 16306228 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
SIK3 YWHAB 25348397 N/A physical interaction ComPPI
SIK3 YWHAH 25348397 N/A physical interaction ComPPI
SIK3 SFN 25348397 N/A physical interaction ComPPI
SIK3 TRAF1 25348397 N/A physical interaction ComPPI
SIK3 TRIP6 21516116 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SIK3 PPP3CA 25348397 N/A physical interaction ComPPI
SIK3 PPP3CC 25348397 N/A physical interaction ComPPI
SIK3 SIK1 25348397 N/A physical interaction ComPPI
SIK3 TRIM25 25348397 N/A physical interaction ComPPI
SIK3 HIF1AN 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
MAPT SIK3 24234451 26402096 association anti bait coimmunoprecipitation IntAct
OCIAD2 SIK3 24234451 30021884 physical association cross-linking study IntAct
SIK3 CRTC2 15454081 16306228 18669648 27898060 inhibition N/A OmniPath
STK11 SIK3 14976552 19369195 27898060 stimulant N/A OmniPath

Visualization










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