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GENE：AMPH

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol AMPH
FullNmae amphiphysin
LocusType gene with protein product
Status Approved
HGNC_id HGNC:471
EnsembleID ENSG00000078053
Uniprot P49418

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
AMPH autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
AMPH GO:0005515,GO:0005543,GO:0005543,GO:0005829,GO:0005886,GO:0006897,GO:0007268,GO:0008021,GO:0015629,GO:0030672,GO:0031256,GO:0048488

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
AMPH hsa:273 path:hsa04144 Endocytosis - Homo sapiens (human)
AMPH hsa:273 path:hsa04666 Fc gamma R-mediated phagocytosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AMPH PPP3CC 23180781 25416956 physical association two hybrid InnateDB
AMPH DEUP1 23180781 25416956 physical association two hybrid InnateDB

Source Target Pmid Interactiontype Methods Database
AR AMPH 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 AMPH 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA1 AMPH 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 AMPH 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 AMPH 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 AMPH 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 AMPH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF AMPH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 AMPH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 AMPH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 AMPH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A AMPH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A AMPH N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000324096 AMPH 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
CSNK2A1 AMPH 22135298 phosphorylation N/A PhosphoSite
CDK1 AMPH 22135298 phosphorylation N/A PhosphoSite
DYRK1A AMPH 22135298 phosphorylation N/A PhosphoSite
CDK5 AMPH 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
SYNJ2 AMPH 25361965 interaction type N/A PTMCode2
AMPH SYNJ2 25361965 interaction type N/A PTMCode2
AMPH DNM2 25361965 interaction type N/A PTMCode2
DNM2 AMPH 25361965 interaction type N/A PTMCode2
AMPH DNM1 25361965 interaction type N/A PTMCode2
DNM1 AMPH 25361965 interaction type N/A PTMCode2
AMPH AP2A2 25361965 interaction type N/A PTMCode2
AP2A2 AMPH 25361965 interaction type N/A PTMCode2
CDK5R1 AMPH 25361965 interaction type N/A PTMCode2
AMPH CDK5R1 25361965 interaction type N/A PTMCode2
CLTC AMPH 25361965 interaction type N/A PTMCode2
AMPH CLTC 25361965 interaction type N/A PTMCode2
SYN1 AMPH 25361965 interaction type N/A PTMCode2
AMPH SYN1 25361965 interaction type N/A PTMCode2
AMPH CDK5 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
ARL16 AMPH 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SH3GLB1 AMPH 12456676 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CALM1 AMPH 25348397 N/A physical interaction ComPPI
CDK5R1 AMPH 11113134 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
KHDRBS1 AMPH 25348397 N/A physical interaction ComPPI
SYN1 AMPH 10899172 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
UBC AMPH 25348397 N/A physical interaction ComPPI
PLD2 AMPH 10764771 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
VTN AMPH 12565847 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
HAX1 AMPH 25348397 N/A physical interaction ComPPI
DNM1 AMPH 10542231 10899172 11877424 14525934 15834155 24234451 25348397 9148966 9348539 9694653 N/A experimental interaction detection,peptide array,pull down,surface plasmon resonance,physical interaction,enzyme linked immunosorbent assay,in vitro ComPPI,HPRD,IntAct
MAPK6 AMPH 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TP73 AMPH 25348397 N/A physical interaction ComPPI
AP2A2 AMPH 10748223 14525934 25348397 8552632 9195986 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
REPS1 AMPH 25348397 N/A physical interaction ComPPI
REPS2 AMPH 25348397 N/A physical interaction ComPPI
CLTC AMPH 10748223 11382783 14525934 14981508 17762867 25348397 27898060 9195986 9280305 9603201 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
AP2A1 AMPH 25348397 N/A physical interaction ComPPI
AP2B1 AMPH 25348397 N/A physical interaction ComPPI
AP1B1 AMPH 25348397 N/A physical interaction ComPPI
ITSN1 AMPH 25348397 N/A physical interaction ComPPI
BIN1 AMPH 14525934 25348397 9348539 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
AP1G1 AMPH 25348397 N/A physical interaction ComPPI
TNK2 AMPH 25348397 N/A physical interaction ComPPI
SYNJ1 AMPH 10542231 14525934 14704270 24234451 25348397 N/A experimental interaction detection,peptide array,phage display,physical interaction,in vitro ComPPI,HPRD,IntAct
AMPH CABIN1 10931822 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
AMPH CDK5 11113134 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
AMPH NECAP1 14525934 17762867 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
AMPH PLD1 25348397 N/A physical interaction ComPPI
AMPH PTK2 25348397 N/A physical interaction ComPPI
AMPH ITSN2 25348397 N/A physical interaction ComPPI
AMPH SGIP1 25348397 N/A physical interaction ComPPI
AMPH SYNM 25348397 N/A physical interaction ComPPI
AMPH DNM2 10542231 14525934 15834155 16696976 17676042 24234451 25348397 27898060 association experimental interaction detection,peptide array,surface plasmon resonance,physical interaction ComPPI,HPRD,IntAct,OmniPath
AMPH TERF1 21044950 24234451 25348397 physical association pull down,physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
AMPH DYRK1A 25348397 N/A physical interaction ComPPI
AMPH MANEA 25348397 N/A physical interaction ComPPI
AMPH PPP3CC 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
AMPH DEUP1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
AMPH NUFIP1 25348397 N/A physical interaction ComPPI
AMPH DGUOK 25348397 N/A physical interaction ComPPI
AMPH DNAAF2 25348397 N/A physical interaction ComPPI
AMPH BIN2 25348397 N/A physical interaction ComPPI
AMPH AP2M1 25348397 N/A physical interaction ComPPI
AMPH AP2S1 25348397 N/A physical interaction ComPPI
AMPH AAGAB 25348397 N/A physical interaction ComPPI
AMPH CLIP4 25348397 N/A physical interaction ComPPI
AMPH DNM3 10542231 24234451 25348397 association peptide array ComPPI,IntAct
AMPH PROP1 23732115 24234451 25348397 physical association two hybrid ComPPI,IntAct
SH3GL2 AMPH 14525934 25348397 9315708 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
AMPH AMPH 10899172 14525934 14529717 N/A experimental interaction detection HPRD
CDK1 AMPH 11113134 14525934 N/A experimental interaction detection HPRD
CDK5 AMPH 11113134 17419807 27898060 stimulant N/A OmniPath
SRC AMPH 11113134 27898060 N/A N/A OmniPath
MAPK3 AMPH 15262992 27898060 inhibition N/A OmniPath
MAPK1 AMPH 15262992 27898060 inhibition N/A OmniPath
CSNK2A1 AMPH 16945112 27898060 inhibition N/A OmniPath
DYRK1A AMPH 11113134 15262992 16733250 27898060 inhibition N/A OmniPath

Visualization










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