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GENE：HERC4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol HERC4
FullNmae HECT and RLD domain containing E3 ubiquitin protein ligase 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:24521
EnsembleID ENSG00000148634
Uniprot Q5GLZ8

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
HERC4 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
HERC4 GO:0001650,GO:0005737,GO:0005829,GO:0006511,GO:0007283,GO:0016567,GO:0016567,GO:0030154,GO:0045879,GO:0061630

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
HERC4 hsa:26091 path:hsa04120 Ubiquitin mediated proteolysis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR HERC4 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 HERC4 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 HERC4 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 HERC4 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 HERC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA HERC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF HERC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 HERC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 HERC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 HERC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 HERC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 HERC4 20584899 rna interference,inhibition experimental interaction detection miRSponge
URS0000338542 HERC4 20584899 25416803 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection TarBase
URS0000153377 HERC4 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
GMNN HERC4 25348397 N/A physical interaction ComPPI
BAG3 HERC4 25348397 N/A physical interaction ComPPI
PCNA HERC4 25348397 N/A physical interaction ComPPI
LSM6 HERC4 25348397 N/A physical interaction ComPPI
HSP90AB1 HERC4 22939624 24234451 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
UBE2E3 HERC4 25348397 N/A physical interaction ComPPI
RB1 HERC4 25348397 N/A physical interaction ComPPI
UBE2D2 HERC4 25348397 N/A physical interaction ComPPI
UBE2L3 HERC4 25348397 N/A physical interaction ComPPI
UBC HERC4 25348397 N/A physical interaction ComPPI
HSP90AA1 HERC4 25348397 N/A physical interaction ComPPI
NTRK1 HERC4 25348397 N/A physical interaction ComPPI
DNAJC7 HERC4 25348397 N/A physical interaction ComPPI
RAD23A HERC4 25348397 N/A physical interaction ComPPI
TRIM25 HERC4 25348397 N/A physical interaction ComPPI
SHMT2 HERC4 25348397 N/A physical interaction ComPPI
WARS1 HERC4 25348397 N/A physical interaction ComPPI
C1ORF94 HERC4 25348397 N/A physical interaction ComPPI
USP5 HERC4 25348397 N/A physical interaction ComPPI
NUF2 HERC4 25348397 N/A physical interaction ComPPI
HERC6 HERC4 14525934 18535780 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
HERC4 H2AZ2 25348397 N/A physical interaction ComPPI
HERC4 MOV10 25348397 N/A physical interaction ComPPI
HERC4 NXF1 25348397 N/A physical interaction ComPPI
HERC4 FAM189B 25348397 N/A physical interaction ComPPI
HERC4 WRAP73 25348397 N/A physical interaction ComPPI
HERC4 NLRX1 25348397 N/A physical interaction ComPPI
TRADD HERC4 24234451 30561431 association virotrap IntAct

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