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GENE：PARD6A

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PARD6A
FullNmae par-6 family cell polarity regulator alpha
LocusType gene with protein product
Status Approved
HGNC_id HGNC:15943
EnsembleID ENSG00000102981
Uniprot Q9NPB6

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PARD6A autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PARD6A GO:0001726,GO:0001933,GO:0005515,GO:0005634,GO:0005634,GO:0005813,GO:0005829,GO:0005886,GO:0005923,GO:0005938,GO:0007098,GO:0007098,GO:0007163,GO:0016032,GO:0016324,GO:0030742,GO:0031267,GO:0034451,GO:0045197,GO:0045197,GO:0045217,GO:0050714,GO:0051301,GO:0060341,GO:0070160,GO:0120157,GO:0120157,GO:1904781

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PARD6A hsa:50855 path:hsa04015 Rap1 signaling pathway - Homo sapiens (human)
PARD6A hsa:50855 path:hsa04144 Endocytosis - Homo sapiens (human)
PARD6A hsa:50855 path:hsa04360 Axon guidance - Homo sapiens (human)
PARD6A hsa:50855 path:hsa04390 Hippo signaling pathway - Homo sapiens (human)
PARD6A hsa:50855 path:hsa04530 Tight junction - Homo sapiens (human)
PARD6A hsa:50855 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TGFBR1 PARD6A 11133108 14557817 15265520 15548370 15761148 15761153 16474430 17934056 19010789 19109155 19114990 19920116 20060931 20519943 20644162 21278795 21614932 21900405 22315516 22703233 22949611 23331499 24132110 24336330 26192618 7594497 interaction type,stimulation N/A ACSN,SignaLink
TGFB1 PARD6A 11133108 14557817 15265520 15548370 15761148 15761153 16474430 17934056 19010789 19109155 19920116 20060931 20519943 20644162 21278795 21614932 21900405 22315516 22703233 22949611 24132110 24336330 26192618 7594497 interaction type N/A ACSN
TGFBR2 PARD6A 11133108 14557817 15265520 15548370 15761148 15761153 16474430 17934056 19010789 19109155 19920116 20060931 20519943 20644162 21278795 21614932 21900405 22315516 22703233 22949611 24132110 24336330 26192618 7594497 interaction type N/A ACSN
SMURF1 PARD6A 14657501 14722617 14744429 15265520 15761148 16472676 21572392 22949611 26192618 association N/A ACSN
PARD6A RHOA 14657501 14722617 14744429 15265520 15761148 16472676 21572392 22949611 26192618 interaction type N/A ACSN
PARD6A PRKCI 11260256 23180781 physical association two hybrid InnateDB
PARD6A PRKCZ 10873802 11260256 23180781 physical association anti tag coimmunoprecipitation,two hybrid,pull down InnateDB
RAC1 PARD6A 11260256 23180781 physical association two hybrid,pull down InnateDB
PARD6A CDC42 11260256 23180781 physical association two hybrid,pull down InnateDB
CDH5 PARD6A 17057644 23180781 physical association anti tag coimmunoprecipitation InnateDB
PARD6A SMURF1 19114990 21262463 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
CEBPA PARD6A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PARD6A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 PARD6A 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
PRKCI PARD6A 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
PARD6A ECT2 25361965 interaction type N/A PTMCode2
ECT2 PARD6A 25361965 interaction type N/A PTMCode2
PARD6A RHOQ 25361965 interaction type N/A PTMCode2
RHOQ PARD6A 25361965 interaction type N/A PTMCode2
PARD6A PRKCG 25361965 interaction type N/A PTMCode2
PRKCG PARD6A 25361965 interaction type N/A PTMCode2
PARD6A PRKCI 25361965 interaction type N/A PTMCode2
PARD6A MARK4 25361965 interaction type N/A PTMCode2
MARK4 PARD6A 25361965 interaction type N/A PTMCode2
PARD6A CDC42 25361965 interaction type N/A PTMCode2
CDC42 PARD6A 25361965 interaction type N/A PTMCode2
PARD6A CDH5 25361965 interaction type N/A PTMCode2
CDH5 PARD6A 25361965 interaction type N/A PTMCode2
PARD6A RAC1 25361965 interaction type N/A PTMCode2
RAC1 PARD6A 25361965 interaction type N/A PTMCode2
PARD6A CRB3 25361965 interaction type N/A PTMCode2
CRB3 PARD6A 25361965 interaction type N/A PTMCode2
PARD6A PARD6B 25361965 interaction type N/A PTMCode2
PARD6B PARD6A 25361965 interaction type N/A PTMCode2
PARD6A PARD3 25361965 interaction type N/A PTMCode2
PARD3 PARD6A 25361965 interaction type N/A PTMCode2
PARD6A PRKCZ 25361965 interaction type N/A PTMCode2
PRKCZ PARD6A 25361965 interaction type N/A PTMCode2
PARD6A LLGL2 25361965 interaction type N/A PTMCode2
LLGL2 PARD6A 25361965 interaction type N/A PTMCode2
PARD6A MARK2 25361965 interaction type N/A PTMCode2
MARK2 PARD6A 25361965 interaction type N/A PTMCode2
MAP2K5 PARD6A 25361965 interaction type N/A PTMCode2
PARD6A MAP2K5 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CDC42 PARD6A 10873802 10934474 11260256 12606577 14525934 14676191 24234451 25348397 association,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
PALS1 PARD6A 25348397 N/A physical interaction ComPPI
TP53BP2 PARD6A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
WDR83 PARD6A 25348397 N/A physical interaction ComPPI
RAC1 PARD6A 11260256 14525934 24234451 25348397 physical association two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
PNMA1 PARD6A 14676191 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
SMURF2 PARD6A 19379695 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ASH1L PARD6A 25348397 N/A physical interaction ComPPI
GRB2 PARD6A 25348397 N/A physical interaction ComPPI
YWHAZ PARD6A 14525934 14676191 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TUBG1 PARD6A 25348397 N/A physical interaction ComPPI
PIK3R3 PARD6A 25348397 N/A physical interaction ComPPI
DGKZ PARD6A 25348397 N/A physical interaction ComPPI
CDH5 PARD6A 14525934 17057644 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,in vitro,in vivo ComPPI,HPRD,IntAct
RHOQ PARD6A 10934474 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
SMARCA4 PARD6A 25348397 N/A physical interaction ComPPI
PRKCH PARD6A 14525934 17335965 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PRKCZ PARD6A 11260256 12813044 14525934 14676191 16189514 17057644 17335965 17350623 24234451 25348397 25852190 colocalization,association,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,two hybrid pooling approach,imaging technique,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
PLCB1 PARD6A 14525934 15782111 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PRKCG PARD6A 14525934 14676191 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PKHD1 PARD6A 25348397 N/A in vitro,in vivo ComPPI
PARD3 PARD6A 11257119 12459187 14525934 14676191 17057644 24234451 25348397 26496610 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
PARD6A MARK2 14525934 14676191 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PARD6A YWHAH 14525934 14676191 24234451 25348397 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
PARD6A MARK4 14525934 14676191 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PARD6A CRB3 14525934 14718572 25348397 27898060 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
PARD6A PARD6B 14525934 14676191 24234451 25348397 26496610 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
PARD6A ECT2 14525934 15254234 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
PARD6A PLCB3 14525934 15782111 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,in vivo ComPPI,HPRD,IntAct
PARD6A GLS 12629547 14525934 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
PARD6A MAP2K5 25348397 N/A two hybrid,physical interaction,in vivo ComPPI
PARD6A DVL2 14525934 19379695 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,in vivo ComPPI,HPRD,IntAct
PARD6A LLGL1 14676191 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PARD6A RPAP3 14676191 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PARD6A PDRG1 14676191 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PARD6A LLGL2 14676191 20360068 24234451 25348397 26496610 association,physical association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
PARD6A PIH1D1 14676191 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PARD6A DNAAF10 14676191 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PARD6A SUGT1 14676191 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PARD6A SMURF1 25348397 N/A physical interaction ComPPI
PARD6A TJP1 25348397 N/A physical interaction ComPPI
PARD6A VHL 25348397 N/A physical interaction ComPPI
PARD6A FBXO31 25348397 N/A physical interaction ComPPI
PARD6A RICTOR 25348397 N/A physical interaction ComPPI
PARD6A APP 25348397 N/A physical interaction ComPPI
PARD6A TGFBR1 14525934 15761153 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
PARD6A EPHB4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PARD6A GLUD1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PARD6A ORC2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PARD6A PMS2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PARD6A PMS2CL 25348397 N/A physical interaction ComPPI
PARD6A TTC3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PARD6A PRDX3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PARD6A RASSF8 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PARD6A PIK3R4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PARD6A SIRT6 25348397 N/A physical interaction ComPPI
PARD6A MAP3K20 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PARD6A NOL8 25348397 N/A physical interaction ComPPI
PARD6A ELP3 25348397 N/A physical interaction ComPPI
PARD6A PLXNA3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PARD6A ARID5B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PARD6A TMEM126A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PARD6A LRCH3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PARD6A DPP9 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PARD6A HTT 24234451 25348397 25942483 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PARD6A PATJ 17057644 24234451 25348397 physical association pull down ComPPI,IntAct
PRKCI PARD6A 11257119 11260256 12813044 14525934 14676191 15590654 16189514 17057644 21516116 24234451 25348397 26496610 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,coimmunoprecipitation,experimental interaction detection,x-ray crystallography,physical interaction,two hybrid pooling approach,in vitro,two hybrid ComPPI,HPRD,IntAct
KIF1B PARD6A 25348397 N/A physical interaction ComPPI
ARHGAP17 PARD6A 25348397 N/A physical interaction ComPPI
PARD6A PRKCA 22544755 27898060 stimulant N/A OmniPath
TGFBR2 PARD6A 15761148 23249950 27898060 stimulant N/A OmniPath
PARD6A RAC1 10873802 11260256 27898060 N/A N/A OmniPath
PRKCZ PARD6A 10873802 11260256 12813044 14676191 14685273 15254234 16189514 16510873 17057644 17335965 17350623 25852190 27898060 N/A N/A OmniPath
PARD6A PRKCZ 10873802 11260256 12813044 14676191 14685273 15254234 16189514 16510873 17057644 17335965 17350623 25852190 27898060 N/A N/A OmniPath
PRKCI PARD6A 11257119 11260256 12813044 14676191 15590654 16189514 16861740 17057644 21516116 23249950 25416956 26496610 27898060 N/A N/A OmniPath
PARD6A CDC42 10873802 10934474 11260256 12606577 14676191 27898060 N/A N/A OmniPath
TGFBR1 PARD6A 15761153 19114990 27898060 stimulant N/A OmniPath
DVL2 PARD6A 19379695 23151663 27898060 stimulant N/A OmniPath
PARD6A SMURF1 15761148 19114990 2126246 21262463 27898060 stimulant N/A OmniPath

Visualization










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