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GENE：PKP4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PKP4
FullNmae plakophilin 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9026
EnsembleID ENSG00000144283
Uniprot Q99569

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PKP4 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PKP4 GO:0000922,GO:0001533,GO:0005515,GO:0005634,GO:0005737,GO:0005737,GO:0005856,GO:0005886,GO:0005886,GO:0005886,GO:0005911,GO:0005912,GO:0007043,GO:0007043,GO:0007267,GO:0009898,GO:0014069,GO:0030054,GO:0030057,GO:0030155,GO:0030496,GO:0032467,GO:0043547,GO:0044291,GO:0045296,GO:0048471,GO:0051233,GO:0072686,GO:0098609

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ERBIN PKP4 16203728 23180781 physical association two hybrid InnateDB
PDZD2 PKP4 12370826 23180781 physical association anti tag coimmunoprecipitation InnateDB
TRIM23 PKP4 23180781 25416956 physical association two hybrid InnateDB

Source Target Pmid Interactiontype Methods Database
AR PKP4 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 PKP4 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA1 PKP4 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 PKP4 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 PKP4 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 PKP4 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
PRDM14 PKP4 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 PKP4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PKP4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PKP4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 PKP4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PKP4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PKP4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PKP4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PKP4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 PKP4 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000F31F4 PKP4 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 PKP4 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00001F5B39 PKP4 25416803 25760387 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
PDZD2 PKP4 25361965 interaction type N/A PTMCode2
PKP4 PDZD2 25361965 interaction type N/A PTMCode2
DSP PKP4 25361965 interaction type N/A PTMCode2
PKP4 DSP 25361965 interaction type N/A PTMCode2
CDH1 PKP4 25361965 interaction type N/A PTMCode2
PKP4 CDH1 25361965 interaction type N/A PTMCode2
CDH5 PKP4 25361965 interaction type N/A PTMCode2
PKP4 CDH5 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GOLGA2 PKP4 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PKP4 ATPAF2 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PKP4 LZTS2 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PKP4 DSC3 12615965 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,OmniPath
PKP4 CDH5 12426320 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
PKP4 ERBIN 12047349 24234451 24550280 25348397 colocalization,physical association anti bait coimmunoprecipitation,two hybrid,phage display,pull down,physical interaction,fluorescence microscopy,in vitro,in vivo ComPPI,IntAct
PKP4 PDZD2 10896674 12370826 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PKP4 DSP 12047349 12426320 14525934 24234451 25348397 colocalization two hybrid,experimental interaction detection,physical interaction,fluorescence microscopy,in vivo,two hybrid ComPPI,HPRD,IntAct
PKP4 GABARAP 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PKP4 MINK1 14525934 15032605 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
PKP4 PSEN1 10037471 10092585 14525934 24234451 25348397 physical association two hybrid,coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
PKP4 CDH1 25348397 N/A physical interaction ComPPI
PKP4 CDH2 25348397 N/A physical interaction ComPPI
PKP4 OSGEP 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PKP4 LNX1 25348397 N/A physical interaction ComPPI
PKP4 ATP6V1B1 25348397 N/A physical interaction ComPPI
PKP4 PAXIP1 25348397 N/A physical interaction ComPPI
PKP4 LATS1 24234451 24255178 25348397 colocalization physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PKP4 LATS2 25348397 N/A physical interaction ComPPI
PKP4 SAV1 24234451 24255178 25348397 colocalization physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PKP4 TRIM23 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PKP4 MOV10 25348397 N/A physical interaction ComPPI
PKP4 NXF1 25348397 N/A physical interaction ComPPI
PKP4 CLEC11A 25348397 N/A physical interaction ComPPI
PKP4 PTGER3 25348397 N/A physical interaction ComPPI
PKP4 TMEM17 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PKP4 UBASH3B 25348397 N/A physical interaction ComPPI
PKP4 CAPZA2 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
PKP4 CLTC 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
PKP4 USP7 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
PKP4 MATR3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PKP4 NES 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
PKP4 RACGAP1 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
PKP4 GTSE1 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
PKP4 FERMT3 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
PKP4 MCM2 25348397 N/A physical interaction ComPPI
PKP4 SCRIB 24234451 24550280 25348397 30126976 colocalization,physical association anti tag coimmunoprecipitation,phage display,physical interaction,fluorescence microscopy,p8 filamentous phage display ComPPI,IntAct
PKP4 PTPRK 25348397 N/A physical interaction ComPPI
PKP4 CDH8 25348397 N/A physical interaction ComPPI
PKP4 CTNNA3 25348397 N/A physical interaction ComPPI
PKP4 APBA3 25348397 N/A physical interaction ComPPI
PKP4 TMEM52B 25348397 N/A physical interaction ComPPI
PKP4 TACR1 25348397 N/A physical interaction ComPPI
PKP4 HAVCR2 25348397 N/A physical interaction ComPPI
PKP4 KCNJ5 25348397 N/A physical interaction ComPPI
PKP4 FGFR2 25348397 N/A physical interaction ComPPI
PKP4 C16ORF54 25348397 N/A physical interaction ComPPI
PKP4 MRAP2 25348397 N/A physical interaction ComPPI
PKP4 TRIM25 25348397 N/A physical interaction ComPPI
PKP4 PGAM1 14525934 16169070 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PKP4 CTNNB1 12047349 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
PKP4 PTPRC 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
PKP4 PTPRJ 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
PKP4 ATP6V1A 25348397 N/A anti bait coimmunoprecipitation ComPPI
PKP4 DLG1 24234451 24550280 25348397 30126976 physical association phage display,p8 filamentous phage display ComPPI,IntAct
PKP4 LRRC7 24234451 24550280 25348397 physical association phage display ComPPI,IntAct
PKP4 DLG4 24234451 30126976 N/A p8 filamentous phage display IntAct
PKP4 PATJ 24234451 30126976 N/A p8 filamentous phage display IntAct
ERBIN PKP4 11711544 11821434 12047349 16203728 27898060 N/A N/A OmniPath
PKP4 ERBIN 11711544 11821434 12047349 16203728 27898060 N/A N/A OmniPath

Visualization










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