GENE：ATP1A4
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | ATP1A4 |
| FullNmae | ATPase Na+/K+ transporting subunit alpha 4 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:14073 |
| EnsembleID | ENSG00000132681 |
| Uniprot | Q13733 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| ATP1A4 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| ATP1A4 | GO:0005391,GO:0005391,GO:0005391,GO:0005391,GO:0005515,GO:0005524,GO:0005886,GO:0005886,GO:0005886,GO:0005890,GO:0005890,GO:0005890,GO:0006811,GO:0006813,GO:0006814,GO:0006883,GO:0007166,GO:0007283,GO:0009566,GO:0010248,GO:0016887,GO:0019829,GO:0019900,GO:0030007,GO:0030317,GO:0030317,GO:0030641,GO:0035725,GO:0035725,GO:0036376,GO:0042391,GO:0042995,GO:0045121,GO:0046872,GO:0051649,GO:0071805,GO:0071805,GO:0097225,GO:0097733,GO:0120200,GO:0150104,GO:1902600,GO:1902600,GO:1990573 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| ATP1A4 | hsa:480 | path:hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
| ATP1A4 | hsa:480 | path:hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
| ATP1A4 | hsa:480 | path:hsa04260 | Cardiac muscle contraction - Homo sapiens (human) |
| ATP1A4 | hsa:480 | path:hsa04261 | Adrenergic signaling in cardiomyocytes - Homo sapiens (human) |
| ATP1A4 | hsa:480 | path:hsa04911 | Insulin secretion - Homo sapiens (human) |
| ATP1A4 | hsa:480 | path:hsa04918 | Thyroid hormone synthesis - Homo sapiens (human) |
| ATP1A4 | hsa:480 | path:hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| ATP1A4 | hsa:480 | path:hsa04925 | Aldosterone synthesis and secretion - Homo sapiens (human) |
| ATP1A4 | hsa:480 | path:hsa04960 | Aldosterone-regulated sodium reabsorption - Homo sapiens (human) |
| ATP1A4 | hsa:480 | path:hsa04961 | Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human) |
| ATP1A4 | hsa:480 | path:hsa04964 | Proximal tubule bicarbonate reclamation - Homo sapiens (human) |
| ATP1A4 | hsa:480 | path:hsa04970 | Salivary secretion - Homo sapiens (human) |
| ATP1A4 | hsa:480 | path:hsa04971 | Gastric acid secretion - Homo sapiens (human) |
| ATP1A4 | hsa:480 | path:hsa04972 | Pancreatic secretion - Homo sapiens (human) |
| ATP1A4 | hsa:480 | path:hsa04973 | Carbohydrate digestion and absorption - Homo sapiens (human) |
| ATP1A4 | hsa:480 | path:hsa04974 | Protein digestion and absorption - Homo sapiens (human) |
| ATP1A4 | hsa:480 | path:hsa04976 | Bile secretion - Homo sapiens (human) |
| ATP1A4 | hsa:480 | path:hsa04978 | Mineral absorption - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | ATP1A4 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| YBX1 | ATP1A4 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| CEBPA | ATP1A4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | ATP1A4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | ATP1A4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | ATP1A4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| H4C1 | ATP1A4 | 25348397 | N/A | physical interaction | ComPPI |
| COPS5 | ATP1A4 | 25348397 | N/A | physical interaction | ComPPI |
| CUL3 | ATP1A4 | 25348397 | N/A | physical interaction | ComPPI |
| CAND1 | ATP1A4 | 25348397 | N/A | physical interaction | ComPPI |
| RPGR | ATP1A4 | 25348397 | N/A | physical interaction | ComPPI |
| CHRM3 | ATP1A4 | 25348397 | N/A | physical interaction | ComPPI |
| CYLD | ATP1A4 | 25348397 | N/A | physical interaction | ComPPI |
| PTP4A3 | ATP1A4 | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |