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GENE：ALDH5A1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ALDH5A1
FullNmae aldehyde dehydrogenase 5 family member A1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:408
EnsembleID ENSG00000112294
Uniprot P51649

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ALDH5A1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ALDH5A1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ALDH5A1 GO:0004777,GO:0004777,GO:0004777,GO:0005739,GO:0005739,GO:0005739,GO:0005739,GO:0005759,GO:0006105,GO:0006536,GO:0007417,GO:0009450,GO:0009450,GO:0009450,GO:0009450,GO:0009791,GO:0042135,GO:0042802

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ALDH5A1 hsa:7915 path:hsa00250 Alanine, aspartate and glutamate metabolism - Homo sapiens (human)
ALDH5A1 hsa:7915 path:hsa00650 Butanoate metabolism - Homo sapiens (human)
ALDH5A1 hsa:7915 path:hsa01100 Metabolic pathways - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 ALDH5A1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 ALDH5A1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA3 ALDH5A1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 ALDH5A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ALDH5A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ALDH5A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 ALDH5A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ALDH5A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ALDH5A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ALDH5A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ALDH5A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 ALDH5A1 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00000F31F4 ALDH5A1 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 ALDH5A1 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS000055128B ALDH5A1 23028679 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000424278 ALDH5A1 23028679 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000183BED ALDH5A1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001CC864 ALDH5A1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003AD2AA ALDH5A1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003380CC ALDH5A1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003E2232 ALDH5A1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000031B6ED ALDH5A1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000040828B ALDH5A1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00003BD367 ALDH5A1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000075BC91 ALDH5A1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000366551 ALDH5A1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000070B1D ALDH5A1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00002F0130 ALDH5A1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000076995 ALDH5A1 25416803 26428001 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
CDK2 ALDH5A1 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
JUN ALDH5A1 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
SSBP1 ALDH5A1 25348397 N/A physical interaction ComPPI
VDAC1 ALDH5A1 25348397 N/A physical interaction ComPPI
PKM ALDH5A1 25348397 N/A physical interaction ComPPI
RPE ALDH5A1 25348397 N/A physical interaction ComPPI
NR3C1 ALDH5A1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
NFKB1 ALDH5A1 24234451 25348397 25609649 association tandem affinity purification ComPPI,IntAct
SEC31A ALDH5A1 25348397 N/A physical interaction ComPPI
TIAL1 ALDH5A1 25348397 N/A physical interaction ComPPI
TOMM40 ALDH5A1 25348397 N/A physical interaction ComPPI
MAGEA11 ALDH5A1 25348397 N/A physical interaction ComPPI
ACO2 ALDH5A1 25348397 N/A physical interaction ComPPI
ADI1 ALDH5A1 25348397 N/A physical interaction ComPPI
SOD2 ALDH5A1 25348397 N/A physical interaction ComPPI
FH ALDH5A1 25348397 N/A physical interaction ComPPI
ABAT ALDH5A1 14525934 25348397 27898060 6470007 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
ALDH5A1 OXLD1 25348397 N/A physical interaction ComPPI
ALDH5A1 ALDH1B1 25348397 N/A physical interaction ComPPI
ALDH5A1 ALDH8A1 25348397 N/A physical interaction ComPPI
ALDH5A1 UMPS 25348397 N/A physical interaction ComPPI
ALDH5A1 ARF5 25348397 N/A physical interaction ComPPI
ALDH5A1 SEC31B 25348397 N/A physical interaction ComPPI
ALDH5A1 GLMP 25348397 N/A physical interaction ComPPI
ALDH5A1 MRPL50 25348397 N/A physical interaction ComPPI
GATC ALDH5A1 25348397 N/A physical interaction ComPPI
FGL1 ALDH5A1 25348397 N/A physical interaction ComPPI
HSCB ALDH5A1 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct
ALDH5A1 ALDH5A1 19300440 24234451 N/A x-ray crystallography IntAct

Visualization










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