GENE：ATG14
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | ATG14 |
| FullNmae | autophagy related 14 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:19962 |
| EnsembleID | ENSG00000126775 |
| Uniprot | Q6ZNE5 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| ATG14 | lysosomal_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| ATG14 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| ATG14 | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| ATG14 | autophagy | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| ATG14 | GO:0000045,GO:0000045,GO:0000045,GO:0000407,GO:0000421,GO:0000423,GO:0000423,GO:0001932,GO:0001933,GO:0001934,GO:0005515,GO:0005776,GO:0005776,GO:0005789,GO:0005829,GO:0005930,GO:0006622,GO:0008333,GO:0009267,GO:0009267,GO:0010608,GO:0016236,GO:0016240,GO:0016241,GO:0034045,GO:0034045,GO:0035032,GO:0035032,GO:0035032,GO:0036092,GO:0042149,GO:0043491,GO:0043495,GO:0043552,GO:0044233,GO:0045022,GO:0045335,GO:0051020,GO:0061635,GO:0090207,GO:0097352,GO:0097629,GO:0097629,GO:0097632,GO:0097632,GO:0098780 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| ATG14 | hsa:22863 | path:hsa04140 | Autophagy - animal - Homo sapiens (human) |
| ATG14 | hsa:22863 | path:hsa05010 | Alzheimer disease - Homo sapiens (human) |
| ATG14 | hsa:22863 | path:hsa05014 | Amyotrophic lateral sclerosis - Homo sapiens (human) |
| ATG14 | hsa:22863 | path:hsa05016 | Huntington disease - Homo sapiens (human) |
| ATG14 | hsa:22863 | path:hsa05017 | Spinocerebellar ataxia - Homo sapiens (human) |
| ATG14 | hsa:22863 | path:hsa05022 | Pathways of neurodegeneration - multiple diseases - Homo sapiens (human) |
| ATG14 | hsa:22863 | path:hsa05131 | Shigellosis - Homo sapiens (human) |
| ATG14 | hsa:22863 | path:hsa05167 | Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| BECN1 | ATG14 | 17106237 17446862 18612260 19270696 22093031 22166994 22421439 22885520 23030059 23180781 23301705 23377657 23725295 24070470 26192618 27754749 28645028 | interaction type,physical association | anti tag coimmunoprecipitation | ACSN,InnateDB |
| PIK3C3 | ATG14 | 17106237 17446862 18612260 18843052 19050071 22093031 22166994 22421439 22885520 23030059 23180781 23301705 23377657 23725295 24070470 26192618 27754749 28645028 | interaction type,physical association | anti tag coimmunoprecipitation | ACSN,InnateDB |
| UVRAG | ATG14 | 16227588 17106237 17446862 17891140 18612260 19265852 22093031 22166994 22421439 22885520 23030059 23301705 23377657 23725295 24070470 26192618 27754749 28645028 | interaction type | N/A | ACSN |
| ATG14 | BECN1 | 18843052 19050071 19270696 23180781 | physical association | anti tag coimmunoprecipitation,two hybrid,pull down,tandem affinity purification | InnateDB |
| ATG14 | PIK3R4 | 18843052 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| ATG14 | PIK3C3 | 18843052 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | ATG14 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | ATG14 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | ATG14 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | ATG14 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA3 | ATG14 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | ATG14 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | ATG14 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | ATG14 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | ATG14 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | ATG14 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | ATG14 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | ATG14 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000040EE1D | ATG14 | 23361941 23446348 25416803 | mrna cleavage,inhibition | experimental interaction detection,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay | TarBase |
| URS0000042E1F | ATG14 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000600E6 | ATG14 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002E1509 | ATG14 | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002E628F | ATG14 | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000171CD1 | ATG14 | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000F0F49 | ATG14 | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000041CB9C | ATG14 | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000007D64A | ATG14 | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000008F0CF | ATG14 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075BDAA | ATG14 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003A5E54 | ATG14 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000059EB31 | ATG14 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004CCA62 | ATG14 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001F373E | ATG14 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002B7450 | ATG14 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000411752 | ATG14 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000005CE28 | ATG14 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000EEF5F | ATG14 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000753AD | ATG14 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000006FDD4 | ATG14 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000298BA3 | ATG14 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000DDD35 | ATG14 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002075FA | ATG14 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002B3783 | ATG14 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000000C73C | ATG14 | 25416803 25650716 | mrna cleavage,inhibition | miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ATG14 | PIK3C3 | 25361965 | interaction type | N/A | PTMCode2 |
| PIK3C3 | ATG14 | 25361965 | interaction type | N/A | PTMCode2 |
| ATG14 | PIK3R4 | 25361965 | interaction type | N/A | PTMCode2 |
| PIK3R4 | ATG14 | 25361965 | interaction type | N/A | PTMCode2 |
| ATG14 | BECN1 | 25361965 | interaction type | N/A | PTMCode2 |
| BECN1 | ATG14 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| RAB39A | ATG14 | 24234451 24349490 25348397 | physical association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| MIS18A | ATG14 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| PCBD1 | ATG14 | 20195357 24234451 25348397 | physical association | display technology | ComPPI,IntAct |
| EXOC8 | ATG14 | 25348397 | N/A | physical interaction | ComPPI |
| CETN2 | ATG14 | 25348397 | N/A | physical interaction | ComPPI |
| NRBF2 | ATG14 | 20562859 24234451 24785657 24849286 25348397 | association,physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction | ComPPI,IntAct |
| MAP4K4 | ATG14 | 25348397 | N/A | physical interaction | ComPPI |
| CHAF1A | ATG14 | 25348397 | N/A | physical interaction | ComPPI |
| PDLIM5 | ATG14 | 25348397 | N/A | physical interaction | ComPPI |
| EXOC1 | ATG14 | 25348397 | N/A | physical interaction | ComPPI |
| EXOC2 | ATG14 | 25348397 | N/A | physical interaction | ComPPI |
| RALB | ATG14 | 25348397 | N/A | physical interaction | ComPPI |
| DVL2 | ATG14 | 25348397 | N/A | physical interaction | ComPPI |
| RNF2 | ATG14 | 25348397 | N/A | physical interaction | ComPPI |
| BECN1 | ATG14 | 19050071 20562859 21062745 22081109 22493499 23112296 23332761 23954414 24034250 24234451 25348397 25490155 25594178 26496610 | phosphorylation reaction,association,physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,electron microscopy,molecular sieving,pull down,physical interaction,two hybrid array,phosphotransferase assay,two hybrid prey pooling approach | ComPPI,IntAct |
| PIK3C3 | ATG14 | 11157979 16421251 18843052 19050071 19270696 20562859 22493499 23262492 23332761 24165940 24234451 24785657 24980960 25348397 25490155 27898060 | phosphorylation reaction,association,physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,electron microscopy,molecular sieving,pull down,physical interaction,phosphotransferase assay | ComPPI,IntAct,OmniPath |
| ELAVL1 | ATG14 | 25348397 | N/A | physical interaction | ComPPI |
| RAD50 | ATG14 | 25348397 | N/A | physical interaction | ComPPI |
| PIK3R4 | ATG14 | 11157979 18843052 19270696 19445518 20562859 22493499 23262492 24165940 24234451 25348397 25490155 27898060 | phosphorylation reaction,association,physical association | anti tag coimmunoprecipitation,electron microscopy,molecular sieving,pull down,physical interaction,phosphotransferase assay | ComPPI,IntAct,OmniPath |
| USP18 | ATG14 | 25348397 | N/A | physical interaction | ComPPI |
| MTFR1 | ATG14 | 25348397 | N/A | physical interaction | ComPPI |
| PCM1 | ATG14 | 25348397 | N/A | physical interaction | ComPPI |
| ATG14 | DACT1 | 25348397 | N/A | physical interaction | ComPPI |
| ATG14 | IRGM | 25348397 | N/A | physical interaction | ComPPI |
| ATG14 | LRRC58 | 25348397 | N/A | physical interaction | ComPPI |
| ATG14 | BECN2 | 23954414 24234451 25348397 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| ATG14 | FSD2 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| ATG14 | ATG14 | 20562859 24234451 | physical association | anti tag coimmunoprecipitation | IntAct |
| FOXO3 | ATG14 | 22992773 27898060 | N/A | N/A | OmniPath |
| FOXO1 | ATG14 | 22992773 27898060 | N/A | N/A | OmniPath |
| ATG14 | BECN1 | 18843052 19050071 19223761 19270693 19270696 20562859 20711182 21062745 22081109 23112296 23878393 23954414 24034250 24980960 25891078 26496610 27898060 | stimulant | N/A | OmniPath |