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GENE：MAP2K6

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MAP2K6
FullNmae mitogen-activated protein kinase kinase 6
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6846
EnsembleID ENSG00000108984
Uniprot P52564

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MAP2K6 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MAP2K6 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MAP2K6 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
MAP2K6 GO:0000165,GO:0000165,GO:0001649,GO:0001934,GO:0002931,GO:0004674,GO:0004708,GO:0004708,GO:0004708,GO:0004713,GO:0005515,GO:0005524,GO:0005654,GO:0005654,GO:0005737,GO:0005829,GO:0005829,GO:0005856,GO:0006915,GO:0007165,GO:0009410,GO:0016310,GO:0019901,GO:0022602,GO:0031098,GO:0032308,GO:0038066,GO:0038066,GO:0042770,GO:0043065,GO:0043410,GO:0051403,GO:0051726,GO:0051770,GO:0060048,GO:0060348,GO:0070423,GO:0072709,GO:0090398,GO:0106310,GO:0120163,GO:1901796

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MAP2K6 hsa:5608 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
MAP2K6 hsa:5608 path:hsa04015 Rap1 signaling pathway - Homo sapiens (human)
MAP2K6 hsa:5608 path:hsa04218 Cellular senescence - Homo sapiens (human)
MAP2K6 hsa:5608 path:hsa04380 Osteoclast differentiation - Homo sapiens (human)
MAP2K6 hsa:5608 path:hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human)
MAP2K6 hsa:5608 path:hsa04664 Fc epsilon RI signaling pathway - Homo sapiens (human)
MAP2K6 hsa:5608 path:hsa04668 TNF signaling pathway - Homo sapiens (human)
MAP2K6 hsa:5608 path:hsa04750 Inflammatory mediator regulation of TRP channels - Homo sapiens (human)
MAP2K6 hsa:5608 path:hsa04912 GnRH signaling pathway - Homo sapiens (human)
MAP2K6 hsa:5608 path:hsa04935 Growth hormone synthesis, secretion and action - Homo sapiens (human)
MAP2K6 hsa:5608 path:hsa04936 Alcoholic liver disease - Homo sapiens (human)
MAP2K6 hsa:5608 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
MAP2K6 hsa:5608 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
MAP2K6 hsa:5608 path:hsa05132 Salmonella infection - Homo sapiens (human)
MAP2K6 hsa:5608 path:hsa05135 Yersinia infection - Homo sapiens (human)
MAP2K6 hsa:5608 path:hsa05145 Toxoplasmosis - Homo sapiens (human)
MAP2K6 hsa:5608 path:hsa05161 Hepatitis B - Homo sapiens (human)
MAP2K6 hsa:5608 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
MAP2K6 hsa:5608 path:hsa05167 Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)
MAP2K6 hsa:5608 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
MAP2K6 hsa:5608 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)
MAP2K6 hsa:5608 path:hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human)
MAP2K6 hsa:5608 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)
MAP2K6 hsa:5608 path:hsa05418 Fluid shear stress and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MAP3K4 MAP2K6 11175814 11274345 12738796 16799472 18855897 21614932 23331499 23850759 24104473 26192618 9305639 9841871 interaction type,stimulation N/A ACSN,SignaLink
MAP3K7 MAP2K6 10391247 11280761 11460167 12620219 14633987 14660645 15082531 15125833 15282297 16200688 16603398 16799562 17301840 17363905 18264787 18641653 18988627 19161412 20060931 20164171 21041997 21133840 21232017 22941947 23331499 24403530 24699077 24958845 26192618 interaction type,stimulation N/A ACSN,SignaLink,SignaLink
GRB2 MAP2K6 10086337 10567412 10811803 10982827 11274345 11447289 11777939 12040186 12175651 12419216 12640133 12738796 12782630 14585353 15567848 15574420 15863030 16102570 16227978 16488589 16582911 16887996 17496910 17673906 18855897 19449109 19568798 19615955 21102635 21614932 24027568 26192618 26552706 7510700 8551221 interaction type N/A ACSN
RIPK1 MAP2K6 11274345 12556535 12655147 12738796 14730360 15592525 17462996 18641653 18855897 19392652 19524513 19632174 21133840 21232017 21614932 23010170 23850759 24378531 26192618 26587781 26653790 28574505 28765050 interaction type N/A ACSN
TNFRSF1A MAP2K6 11274345 12556535 12655147 12738796 14730360 15592525 17462996 18641653 18855897 19392652 19524513 19632174 21133840 21232017 21614932 23010170 23850759 24378531 26192618 26587781 26653790 28574505 28765050 interaction type N/A ACSN
TRADD MAP2K6 11274345 12556535 12655147 12738796 14730360 15592525 17462996 18641653 18855897 19392652 19524513 19632174 21133840 21232017 21614932 23010170 23850759 24378531 26192618 26587781 26653790 28574505 28765050 interaction type N/A ACSN
TRAF2 MAP2K6 11274345 12556535 12655147 12738796 15592525 17462996 18641653 18855897 19392652 21133840 21232017 21614932 23850759 24378531 26192618 interaction type N/A ACSN
TNFRSF1B MAP2K6 11274345 12556535 12655147 12738796 15592525 17462996 18641653 18855897 19392652 21133840 21232017 21614932 23850759 24378531 26192618 interaction type N/A ACSN
MAP3K5 MAP2K6 11274345 12556535 12655147 12738796 15592525 17462996 18641653 18855897 19392652 21133840 21232017 21614932 23331499 23850759 24378531 26192618 8974401 interaction type,stimulation N/A ACSN,SignaLink
IL1R1 MAP2K6 11274345 12620219 12738796 14660645 15125833 16252010 16878026 17704786 17948050 18264787 18758450 18855897 18922473 18977329 19161412 21614932 23070005 23681101 23811849 26192618 interaction type N/A ACSN
IRAK1 MAP2K6 11274345 12620219 12738796 14660645 15125833 16252010 16878026 17704786 17948050 18264787 18758450 18855897 18922473 18977329 19161412 21614932 23070005 23681101 23811849 26192618 interaction type N/A ACSN
MYD88 MAP2K6 11274345 12620219 12738796 14660645 15125833 16252010 16878026 17704786 17948050 18264787 18758450 18855897 18922473 18977329 19161412 21614932 23070005 23681101 23811849 26192618 interaction type N/A ACSN
TRAF6 MAP2K6 11274345 12620219 12738796 14660645 15125833 16252010 16878026 17704786 17948050 18264787 18758450 18855897 18922473 18977329 19161412 21614932 23070005 23681101 23811849 26192618 interaction type N/A ACSN
TGFBR1 MAP2K6 11274345 12738796 14557817 15265520 15282297 16200688 16474430 17934056 18855897 20060931 20519943 21614932 22703233 23070005 24132110 24336330 24403530 26192618 interaction type N/A ACSN
TGFBR2 MAP2K6 11274345 12738796 14557817 15265520 15282297 16200688 16474430 17934056 18855897 20060931 20519943 21614932 22703233 23070005 24132110 24336330 24403530 26192618 interaction type N/A ACSN
MAP2K6 MAP3K7 11460167 21220427 23180781 phosphorylation reaction in-gel kinase assay,protein kinase assay InnateDB
DCTN1 MAP2K6 15375157 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
TAOK2 MAP2K6 10497253 11279118 18988627 23180781 23331499 phosphorylation reaction,stimulation,physical association anti tag coimmunoprecipitation,in-gel kinase assay InnateDB,SignaLink,SignaLink
PLCB2 MAP2K6 12054652 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAP2K6 MAPK14 11242034 16342939 17255097 17255949 18988627 21071413 23180781 23331499 7750576 8622669 8626699 9808624 phosphorylation reaction,stimulation in-gel kinase assay,protein kinase assay InnateDB,SignaLink,SignaLink
MAP2K6 MAP3K4 23180781 9305639 9841871 phosphorylation reaction in-gel kinase assay InnateDB
PPM1A MAP2K6 23180781 9707433 dephosphorylation reaction phosphatase assay InnateDB
MAP2K6 MAP3K20 11836244 23180781 phosphorylation reaction in-gel kinase assay InnateDB
MAP2K6 MAP2K6 10347227 10480932 26467481 8622669 8663074 8974401 phosphorylation reaction,up-regulates,up-regulates activity N/A Signor
MAP2K6 MAPK12 11062067 11242034 18988627 23331499 stimulation N/A SignaLink,SignaLink
MAP2K6 MAPK11 11242034 23331499 stimulation N/A SignaLink,SignaLink
MAP3K11 MAP2K6 23331499 9003778 stimulation N/A SignaLink
MAP2K6 MAPK13 11242034 23331499 9218798 stimulation N/A SignaLink
MAP3K20 MAP2K6 11836244 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
NPHS1 MAP2K6 20005715 interaction type N/A PSP,SignaLink

Source Target Pmid Interactiontype Methods Database
E2F4 MAP2K6 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 MAP2K6 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 MAP2K6 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 MAP2K6 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 MAP2K6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA MAP2K6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MAP2K6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 MAP2K6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MAP2K6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 MAP2K6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 MAP2K6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 MAP2K6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MAP2K6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 MAP2K6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 MAP2K6 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00004F4657 MAP2K6 21351259 rna interference,inhibition array technology,experimental interaction detection miRSponge
URS000048BA36 MAP2K6 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00004F4657 MAP2K6 21351259 25416803 mrna cleavage,inhibition array technology,experimental interaction detection TarBase
URS00005C1F22 MAP2K6 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000C5BAA MAP2K6 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000272039 MAP2K6 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000753AD MAP2K6 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00002971AB MAP2K6 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000001A7A MAP2K6 25416803 27526785 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000040EC3B MAP2K6 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000070CD2 MAP2K6 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000040FA88 MAP2K6 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
MAP3K7 MAP2K6 22135298 phosphorylation N/A PhosphoSite
MAP3K5 MAP2K6 22135298 phosphorylation N/A PhosphoSite
MAP2K6 MAPK12 22135298 phosphorylation N/A PhosphoSite
MAP2K6 MAP2K6 22135298 phosphorylation N/A PhosphoSite
MAP2K6 HSF4 22135298 phosphorylation N/A PhosphoSite
MAP2K6 MAPK14 22135298 phosphorylation N/A PhosphoSite
MAP2K6 PAK6 22135298 phosphorylation N/A PhosphoSite
MAP3K8 MAP2K6 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
CST1 MAP2K6 25348397 N/A physical interaction ComPPI
GADD45G MAP2K6 12052864 24234451 25348397 physical association dihydrofolate reductase reconstruction ComPPI,IntAct
TRAF6 MAP2K6 14525934 16313339 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
RACK1 MAP2K6 25348397 N/A physical interaction ComPPI
PICK1 MAP2K6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MAPK1 MAP2K6 25348397 N/A physical interaction ComPPI
SMAD7 MAP2K6 12589052 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
STAT4 MAP2K6 10961885 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
MAPK14 MAP2K6 14525934 16342939 17255949 24234451 25348397 7750576 8622669 8626699 9808624 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
PKN1 MAP2K6 12761180 14525934 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
GADD45B MAP2K6 12052864 24234451 25348397 physical association dihydrofolate reductase reconstruction ComPPI,IntAct
MAP2K4 MAP2K6 25348397 N/A physical interaction ComPPI
MAP3K5 MAP2K6 14525934 15866172 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
MAP3K4 MAP2K6 12052864 14525934 24234451 25241761 25348397 9841871 physical association two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
MAPK13 MAP2K6 14525934 25348397 9218798 N/A experimental interaction detection,in vitro ComPPI,HPRD
DCTN1 MAP2K6 14525934 15375157 25348397 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
DUSP4 MAP2K6 25348397 N/A physical interaction ComPPI
RELA MAP2K6 14525934 16498455 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,in vitro,proximity ligation assay ComPPI,HPRD,IntAct
MAP2K6 MAPK12 11062067 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MAP2K6 MAP3K7 11460167 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MAP2K6 PLCB2 12054652 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAP2K6 MAP3K20 11836244 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
MAP2K6 TAOK2 10497253 11279118 14525934 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
MAP2K6 PTEN 25348397 N/A physical interaction ComPPI
MAP2K6 TLR3 25348397 N/A physical interaction ComPPI
MAP2K6 LRRK2 20067578 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,physical interaction,fluorescence microscopy ComPPI,IntAct
MAP2K6 MLH1 20706999 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAP2K6 MAPKAPK2 25348397 N/A physical interaction ComPPI
MAP2K6 FBXO31 25348397 N/A physical interaction ComPPI
MAP2K6 MAP2K3 24234451 25241761 25348397 physical association physical interaction,proximity ligation assay ComPPI,IntAct
MAP2K6 ZG16B 25348397 N/A physical interaction ComPPI
MAP2K6 GADD45A 12052864 24234451 25241761 25348397 physical association dihydrofolate reductase reconstruction,physical interaction,proximity ligation assay ComPPI,IntAct
MAP2K6 MAP2K6 14525934 8622669 8663074 N/A experimental interaction detection HPRD
MAP2K6 AQP4 11742978 27898060 N/A N/A OmniPath
SRC MAP2K6 27898060 8622669 N/A N/A OmniPath
MAP2K6 PRKAA2 10642499 27898060 N/A N/A OmniPath
MAP2K6 PLCB2 12054652 16189514 27898060 N/A N/A OmniPath
PLCB2 MAP2K6 12054652 16189514 27898060 N/A N/A OmniPath
MAP3K7 MAP2K6 10094049 10702308 10838074 11460167 12242293 12556533 12609980 14633987 15590691 15764709 16893890 17079228 17363905 17363973 17384642 19675569 20932476 21220427 21902831 23606331 26038599 27898060 stimulant N/A OmniPath
MAP2K6 MAP3K7 10094049 10702308 10838074 11460167 12242293 12556533 12609980 14633987 15590691 15764709 16893890 17079228 17363905 17363973 17384642 19675569 20932476 21220427 23606331 26038599 27898060 N/A N/A OmniPath
MAP2K6 MAPK10 27898060 8974401 stimulant N/A OmniPath
MAP2K6 MAPK9 27898060 8974401 stimulant N/A OmniPath
MAP2K6 BID 11583622 16122426 27898060 N/A N/A OmniPath
MAP3K1 MAP2K6 27898060 9712898 stimulant N/A OmniPath
MAP2K6 MAPK13 11242034 27898060 8663074 9218798 stimulant N/A OmniPath
PPM1A MAP2K6 27898060 9707433 inhibition N/A OmniPath
MAP2K6 PPM1A 27898060 9707433 N/A N/A OmniPath
MAP3K5 MAP2K6 11460167 11689443 12820963 15866172 20213747 27898060 8622669 8974401 stimulant N/A OmniPath
MAP2K6 CDKN2D 10734227 27898060 N/A N/A OmniPath
MAP2K6 MAPK14 10480932 11279118 12697810 15972258 16153436 16342939 16497976 17016520 17255097 17255949 17322306 18088087 18452278 18669648 18691976 18767875 19651622 19901323 20068231 27898060 7750576 8622669 8626699 8974401 9808624 stimulant N/A OmniPath
MAPK14 MAP2K6 11279118 12697810 16342939 17255097 17255949 27898060 7750576 8622669 8626699 8974401 9808624 N/A N/A OmniPath
MAP2K6 CRK 27898060 8663074 stimulant N/A OmniPath
MAP2K6 NFE2L2 16951197 27898060 inhibition N/A OmniPath
MAP3K4 MAP2K6 11274345 12052864 12738796 15866172 16157600 17726008 18855897 21614932 25241761 27898060 9305639 9841871 stimulant N/A OmniPath
MAP2K6 RCAN1 12063245 27898060 N/A N/A OmniPath
MAP2K6 MAPK11 11242034 27898060 8621675 9430721 stimulant N/A OmniPath
MAP2K6 MAPK8 11460167 27898060 stimulant N/A OmniPath
MAP2K6 STAT4 10961885 27898060 N/A N/A OmniPath
MAP2K6 TAOK2 10497253 11279118 25241761 27898060 N/A N/A OmniPath
TAOK2 MAP2K6 10497253 11279118 25241761 27898060 stimulant N/A OmniPath
MAP2K6 HSF4 24361130 27898060 N/A N/A OmniPath
MAP2K6 AFDN 12808105 27898060 N/A N/A OmniPath
MAP2K6 MAPK12 10567720 11062067 1124203 18083107 19230643 19413330 27898060 stimulant N/A OmniPath
MAP2K6 WWOX 12514174 27898060 N/A N/A OmniPath
MAP3K20 MAP2K6 11836244 27898060 stimulant N/A OmniPath
MAP3K11 MAP2K6 27898060 9003778 stimulant N/A OmniPath
MAP2K6 DCTN1 15375157 27898060 N/A N/A OmniPath
MAP3K12 MAP2K6 16728640 19369195 27898060 N/A N/A OmniPath
MAP2K6 PAK6 15550393 27898060 stimulant N/A OmniPath
MAP2K6 JAM2 12953056 27898060 N/A N/A OmniPath

Visualization










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