Gene Information gene info

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GENE：ITSN2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ITSN2
FullNmae intersectin 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6184
EnsembleID ENSG00000198399
Uniprot Q9NZM3

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ITSN2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ITSN2 GO:0005085,GO:0005509,GO:0005515,GO:0005737,GO:0005813,GO:0005829,GO:0005886,GO:0016197,GO:0030154,GO:0042734,GO:0060090,GO:0070062,GO:0097708,GO:0150007,GO:1903861

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 ITSN2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 ITSN2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 ITSN2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 ITSN2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 ITSN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ITSN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ITSN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 ITSN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ITSN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ITSN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ITSN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ITSN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF ITSN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000521626 ITSN2 17612493 25416803 mrna cleavage,inhibition array technology TarBase
URS000009262D ITSN2 18591254 25416803 mrna cleavage,inhibition array technology TarBase
URS000021D7C8 ITSN2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001C770D ITSN2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00004BCD9C ITSN2 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001D69F6 ITSN2 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000008C563 ITSN2 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000013ABA3 ITSN2 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001B341F ITSN2 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000330617 ITSN2 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002E92A8 ITSN2 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CDC42 ITSN2 25361965 interaction type N/A PTMCode2
ITSN2 CDC42 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
HNRNPK ITSN2 25348397 N/A physical interaction ComPPI
PDE4DIP ITSN2 25348397 N/A physical interaction ComPPI
GOLGA2 ITSN2 25348397 N/A physical interaction ComPPI
WASL ITSN2 25348397 N/A physical interaction ComPPI
SH3KBP1 ITSN2 25348397 N/A physical interaction ComPPI
PPP1CC ITSN2 25348397 N/A physical interaction ComPPI
SNAP29 ITSN2 25348397 N/A physical interaction ComPPI
CHIC2 ITSN2 25348397 N/A physical interaction ComPPI
WAS ITSN2 11748279 14525934 22558309 25348397 27898060 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD,OmniPath
ROCK1 ITSN2 25348397 N/A physical interaction ComPPI
TBL3 ITSN2 14525934 16169070 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
KXD1 ITSN2 25348397 N/A physical interaction ComPPI
CBL ITSN2 25348397 N/A physical interaction ComPPI
EZH2 ITSN2 25348397 N/A physical interaction ComPPI
SOS1 ITSN2 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
KHDRBS1 ITSN2 25348397 N/A physical interaction ComPPI
TRIO ITSN2 25348397 N/A physical interaction ComPPI
NBR1 ITSN2 25348397 N/A physical interaction ComPPI
SYN1 ITSN2 25348397 N/A physical interaction ComPPI
PIK3AP1 ITSN2 25348397 N/A physical interaction ComPPI
UBC ITSN2 25348397 N/A physical interaction ComPPI
LSM8 ITSN2 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SOS2 ITSN2 25348397 N/A physical interaction ComPPI
DLGAP1 ITSN2 25348397 N/A physical interaction ComPPI
WIPF2 ITSN2 25348397 N/A physical interaction ComPPI
GPNMB ITSN2 25348397 N/A physical interaction ComPPI
TMF1 ITSN2 25348397 N/A physical interaction ComPPI
STX4 ITSN2 25348397 N/A physical interaction ComPPI
RABEP1 ITSN2 25348397 N/A physical interaction ComPPI
RUFY1 ITSN2 25348397 N/A physical interaction ComPPI
ERC1 ITSN2 25348397 N/A physical interaction ComPPI
REPS1 ITSN2 25348397 N/A physical interaction ComPPI
BCCIP ITSN2 14525934 16169070 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
LTBP4 ITSN2 25348397 N/A physical interaction ComPPI
EPS15 ITSN2 25348397 N/A physical interaction ComPPI
ITSN1 ITSN2 25348397 N/A physical interaction ComPPI
EGFR ITSN2 24234451 24658140 25348397 physical association ubiquitin reconstruction,physical interaction ComPPI,IntAct
FASLG ITSN2 19807924 24234451 25348397 N/A phage display,physical interaction ComPPI,IntAct
MCRS1 ITSN2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PIK3C2B ITSN2 25348397 N/A physical interaction ComPPI
NCKIPSD ITSN2 25348397 N/A physical interaction ComPPI
SYNJ2 ITSN2 12421765 14525934 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
AMPH ITSN2 25348397 N/A physical interaction ComPPI
FCHSD2 ITSN2 25348397 N/A physical interaction ComPPI
RBMX ITSN2 25348397 N/A physical interaction ComPPI
WIPF1 ITSN2 25348397 N/A physical interaction ComPPI
NR2C2 ITSN2 25348397 N/A physical interaction ComPPI
FNBP4 ITSN2 25348397 N/A physical interaction ComPPI
AP2M1 ITSN2 25348397 N/A physical interaction ComPPI
RNF41 ITSN2 25348397 N/A physical interaction ComPPI
EPS15L1 ITSN2 25348397 N/A physical interaction ComPPI
MEGF10 ITSN2 12421765 14525934 24234451 25348397 physical association two hybrid,two hybrid ComPPI,HPRD,IntAct
AP2S1 ITSN2 25348397 N/A physical interaction ComPPI
PDCD6IP ITSN2 25348397 N/A physical interaction ComPPI
KDM1A ITSN2 25348397 N/A physical interaction ComPPI
MAP4K3 ITSN2 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
KIAA1549 ITSN2 12421765 14525934 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SH3GL1 ITSN2 25348397 N/A physical interaction ComPPI
TACC1 ITSN2 25348397 N/A physical interaction ComPPI
TGOLN2 ITSN2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
SRGAP2 ITSN2 25348397 N/A physical interaction ComPPI
GOLGB1 ITSN2 25348397 N/A physical interaction ComPPI
SEMA6A ITSN2 12421765 14525934 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
EZR ITSN2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
AHDC1 ITSN2 25348397 N/A physical interaction ComPPI
AGT ITSN2 25348397 N/A physical interaction ComPPI
PSEN1 ITSN2 25348397 N/A physical interaction ComPPI
ITPKA ITSN2 25348397 N/A physical interaction ComPPI
NINL ITSN2 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PTN ITSN2 14525934 16169070 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CPSF6 ITSN2 25348397 N/A physical interaction ComPPI
HOOK2 ITSN2 25348397 N/A physical interaction ComPPI
YLPM1 ITSN2 25348397 N/A physical interaction ComPPI
MRPL9 ITSN2 25348397 N/A physical interaction ComPPI
CCDC88C ITSN2 25348397 N/A physical interaction ComPPI
LAMP1 ITSN2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
DNM2 ITSN2 25348397 N/A physical interaction ComPPI
FBF1 ITSN2 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PPP4R3A ITSN2 25348397 N/A physical interaction ComPPI
LUC7L3 ITSN2 25348397 N/A physical interaction ComPPI
DST ITSN2 25348397 N/A physical interaction ComPPI
ITSN2 FCHSD1 25348397 N/A physical interaction ComPPI
ITSN2 YTHDF1 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ITSN2 GOLGA8A 25348397 N/A physical interaction ComPPI
ITSN2 KCTD10 25348397 N/A physical interaction ComPPI
ITSN2 ANKRD17 25348397 N/A physical interaction ComPPI
ITSN2 LARP6 25348397 N/A physical interaction ComPPI
ITSN2 MBNL1 25348397 N/A physical interaction ComPPI
ITSN2 WASF2 25348397 N/A physical interaction ComPPI
ITSN2 GAREM2 25348397 N/A physical interaction ComPPI
ITSN2 TM9SF4 25348397 N/A physical interaction ComPPI
ITSN2 GOLT1B 25348397 N/A physical interaction ComPPI
RNF20 ITSN2 25348397 N/A physical interaction ComPPI
ITSN2 RAD9A 12766152 14525934 N/A experimental interaction detection HPRD

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