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GENE：ATXN3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ATXN3
FullNmae ataxin 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7106
EnsembleID ENSG00000066427
Uniprot P54252

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ATXN3 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ATXN3 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ATXN3 GO:0000226,GO:0004843,GO:0004843,GO:0004843,GO:0004843,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005730,GO:0005737,GO:0005759,GO:0005765,GO:0005789,GO:0005829,GO:0005829,GO:0005886,GO:0006289,GO:0006511,GO:0006515,GO:0007268,GO:0007399,GO:0010810,GO:0016363,GO:0016579,GO:0016579,GO:0030036,GO:0031625,GO:0031625,GO:0031966,GO:0034198,GO:0034605,GO:0035520,GO:0035640,GO:0042405,GO:0043161,GO:0045104,GO:0045202,GO:0051117,GO:0061578,GO:0070536,GO:0071108,GO:0071218,GO:1904262,GO:1904294,GO:1904379,GO:1990380

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ATXN3 hsa:4287 path:hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human)
ATXN3 hsa:4287 path:hsa05017 Spinocerebellar ataxia - Homo sapiens (human)
ATXN3 hsa:4287 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 ATXN3 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 ATXN3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ATXN3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 ATXN3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ATXN3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ATXN3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ATXN3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF ATXN3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 ATXN3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 ATXN3 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000277201 ATXN3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005ACA7C ATXN3 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001E0AEA ATXN3 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000032835F ATXN3 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000243FF1 ATXN3 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000013E79D ATXN3 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000427B68 ATXN3 21572407 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004719AB ATXN3 21572407 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000338542 ATXN3 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000085F64 ATXN3 21572407 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000076B539 ATXN3 21572407 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003AA845 ATXN3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000453664 ATXN3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000E7139 ATXN3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002C0FCB ATXN3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000012930C ATXN3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000AD02D ATXN3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000042935A ATXN3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000486E0B ATXN3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000047A67D ATXN3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000F4AC3 ATXN3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000AA464 ATXN3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003E226A ATXN3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005D986D ATXN3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 ATXN3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003AD80B ATXN3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000020579D ATXN3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000913AC ATXN3 23824327 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075C1E1 ATXN3 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002A8BC6 ATXN3 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000032AE90 ATXN3 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00003E5ECC ATXN3 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000137EDE ATXN3 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000019907A ATXN3 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001C770D ATXN3 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00004E008F ATXN3 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000078918 ATXN3 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00003B59DF ATXN3 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00004F2EB0 ATXN3 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000AD002 ATXN3 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000075C4B1 ATXN3 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000007F792 ATXN3 19536157 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000CBE63 ATXN3 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000081E1F ATXN3 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000260A3A ATXN3 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
GSK3B ATXN3 22135298 phosphorylation N/A PhosphoSite
KCTD10 ATXN3 25361965 interaction type N/A PTMCode2
ATXN3 KCTD10 25361965 interaction type N/A PTMCode2
UBE4B ATXN3 25361965 interaction type N/A PTMCode2
ATXN3 UBE4B 25361965 interaction type N/A PTMCode2
RPS27A ATXN3 25361965 interaction type N/A PTMCode2
ATXN3 RPS27A 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
HSPA8 ATXN3 25348397 N/A physical interaction ComPPI
BAG3 ATXN3 25348397 N/A physical interaction ComPPI
CDKN1A ATXN3 25348397 N/A two hybrid,physical interaction ComPPI
TUBB ATXN3 25348397 N/A physical interaction ComPPI
TK1 ATXN3 25348397 N/A two hybrid,physical interaction ComPPI
TRAF6 ATXN3 25348397 N/A physical interaction ComPPI
PSMD7 ATXN3 12944474 14525934 25348397 N/A cosedimentation through density gradient,experimental interaction detection,in vitro,in vivo ComPPI,HPRD
VCP ATXN3 12944474 14525934 16525503 24234451 25348397 physical association anti bait coimmunoprecipitation,cosedimentation through density gradient,experimental interaction detection,physical interaction ComPPI,HPRD,IntAct
SLC25A6 ATXN3 25348397 N/A physical interaction ComPPI
BCL2L1 ATXN3 25348397 N/A physical interaction ComPPI
MARCHF5 ATXN3 25348397 N/A physical interaction ComPPI
PICK1 ATXN3 14525934 16713569 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
RHOG ATXN3 25348397 N/A physical interaction ComPPI
CREBBP ATXN3 12297501 17885668 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SUMO1 ATXN3 25348397 N/A physical interaction ComPPI
EP300 ATXN3 25348397 N/A physical interaction ComPPI
HDAC3 ATXN3 25348397 N/A physical interaction ComPPI
KAT2B ATXN3 25348397 N/A physical interaction ComPPI
PNKP ATXN3 25348397 25590633 27898060 N/A physical interaction ComPPI,OmniPath
UBE2L3 ATXN3 25348397 N/A physical interaction ComPPI
ARHGDIA ATXN3 25348397 N/A physical interaction ComPPI
SDC2 ATXN3 25348397 N/A physical interaction ComPPI
GSK3B ATXN3 25348397 N/A two hybrid,physical interaction ComPPI
NCOR1 ATXN3 25348397 N/A physical interaction ComPPI
SERPINH1 ATXN3 25348397 N/A physical interaction ComPPI
UBB ATXN3 12857950 14525934 25348397 N/A experimental interaction detection,physical interaction,fluorescence microscopy ComPPI,HPRD
UBC ATXN3 12857950 12944474 14559776 14602712 15664989 16040601 16118278 16196087 16432517 18599482 19153604 20622874 20865150 21118805 23314748 23625928 23659897 25144244 25231079 25348397 25448680 25527291 25988170 27898060 N/A pull down,physical interaction ComPPI,OmniPath
HSP90AA1 ATXN3 25348397 N/A physical interaction ComPPI
CANX ATXN3 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
CASP1 ATXN3 14525934 25348397 9535906 N/A experimental interaction detection,in vitro ComPPI,HPRD
HSPA1A ATXN3 25348397 N/A physical interaction ComPPI
HSPA1B ATXN3 25348397 N/A physical interaction ComPPI
DNAJB2 ATXN3 25348397 N/A physical interaction ComPPI
NFKBIA ATXN3 25348397 N/A physical interaction ComPPI
XRCC6 ATXN3 25348397 N/A physical interaction ComPPI
RPS6KA1 ATXN3 25348397 N/A two hybrid,physical interaction ComPPI
SQSTM1 ATXN3 25158237 25348397 27898060 N/A physical interaction ComPPI,OmniPath
EWSR1 ATXN3 14525934 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid ComPPI,HPRD,IntAct
SYVN1 ATXN3 25348397 N/A physical interaction ComPPI
PSMC5 ATXN3 25348397 N/A physical interaction ComPPI
RAD23A ATXN3 10915768 14525934 16713569 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vivo,two hybrid ComPPI,HPRD,IntAct
USP13 ATXN3 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
RPLP0 ATXN3 25348397 N/A physical interaction ComPPI
SRI ATXN3 25348397 N/A physical interaction ComPPI
NEDD8 ATXN3 25348397 N/A physical interaction ComPPI
CHEK1 ATXN3 25348397 N/A physical interaction ComPPI
CUL1 ATXN3 25348397 N/A physical interaction ComPPI
CUL4A ATXN3 25348397 N/A physical interaction ComPPI
TUBA1A ATXN3 25348397 N/A physical interaction ComPPI
FOXO4 ATXN3 21536589 25348397 27898060 N/A physical interaction ComPPI,OmniPath
TRIM63 ATXN3 25348397 N/A physical interaction ComPPI
HDAC6 ATXN3 25348397 N/A physical interaction ComPPI
ITCH ATXN3 25348397 N/A physical interaction ComPPI
HSPH1 ATXN3 25348397 N/A physical interaction ComPPI
MDC1 ATXN3 25348397 N/A physical interaction ComPPI
HAP1 ATXN3 21386698 25348397 27898060 N/A physical interaction,fluorescence microscopy ComPPI,OmniPath
DNM1L ATXN3 25348397 N/A physical interaction ComPPI
ATXN3 TEX11 14525934 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid ComPPI,HPRD,IntAct
ATXN3 PHAF1 14525934 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid ComPPI,HPRD,IntAct
ATXN3 ARHGAP19 14525934 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid ComPPI,HPRD,IntAct
ATXN3 RAD23B 10915768 14525934 16713569 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vivo,two hybrid ComPPI,HPRD,IntAct
ATXN3 UBQLN1 14525934 17082820 25348397 N/A experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD
ATXN3 OTUB2 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
ATXN3 KCTD10 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
ATXN3 UBE4B 25348397 N/A physical interaction,competition binding ComPPI
ATXN3 STUB1 25348397 N/A physical interaction ComPPI
ATXN3 PRKN 20940148 22081612 24063750 25348397 27898060 N/A physical interaction ComPPI,OmniPath
ATXN3 AMFR 25348397 N/A physical interaction ComPPI
ATXN3 DNM2 25348397 N/A two hybrid,physical interaction ComPPI
ATXN3 MKNK1 25348397 N/A two hybrid,physical interaction ComPPI
ATXN3 ANXA7 25348397 N/A two hybrid,physical interaction ComPPI
ATXN3 UBE2S 25348397 N/A physical interaction ComPPI
ATXN3 CSNK2B 18839019 25348397 27898060 N/A physical interaction ComPPI,OmniPath
ATXN3 CREB1 25348397 N/A physical interaction ComPPI
ATXN3 PML 25348397 N/A physical interaction ComPPI
ATXN3 SPRTN 25348397 N/A physical interaction ComPPI
ATXN3 RFFL 25348397 N/A physical interaction ComPPI
ATXN3 PJA1 25348397 N/A physical interaction ComPPI
ATXN3 TRIM55 25348397 N/A physical interaction ComPPI
ATXN3 TRIM54 25348397 N/A physical interaction ComPPI
ATXN3 USP21 25348397 N/A physical interaction ComPPI
ATXN3 ASIC1 25348397 N/A physical interaction ComPPI
ATXN3 APP 25348397 N/A physical interaction ComPPI
ATXN3 MGRN1 25348397 N/A physical interaction ComPPI
ATXN3 MAP3K1 25348397 N/A physical interaction ComPPI
ATXN3 AEBP2 25348397 N/A physical interaction ComPPI
ATXN3 DND1 25348397 N/A physical interaction ComPPI
ATXN3 TOMM20L 25348397 N/A physical interaction ComPPI
ATXN3 SLC3A2 25348397 N/A physical interaction ComPPI
ATXN3 BCL7C 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
ATXN3 RSF1 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
ATXN3 TMCO1 25348397 N/A physical interaction ComPPI
ATXN3 CNOT6 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
ATXN3 CAMSAP3 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
ATXN3 PSRC1 25348397 N/A physical interaction ComPPI
ATXN3 NDUFAF2 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
ATXN3 TIMM23 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
ATXN3 HLA-A 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
ATXN3 SMURF1 25348397 N/A physical interaction ComPPI
ATXN3 HSP90AA2P 25348397 N/A physical interaction ComPPI
ATXN3 TP53 25348397 N/A physical interaction ComPPI
ATXN3 CAPN2 25348397 N/A physical interaction ComPPI
ATXN3 SDHB 25348397 N/A physical interaction ComPPI
ATXN3 COA7 25348397 N/A physical interaction ComPPI
ATXN3 NDUFA4 25348397 N/A physical interaction ComPPI
ATXN3 ACLY 25348397 N/A physical interaction ComPPI
ATXN3 FAM184B 25348397 N/A physical interaction ComPPI
ATXN3 GNPAT 25348397 N/A physical interaction ComPPI
ATXN3 CDK4 25348397 N/A physical interaction ComPPI
ATXN3 HSDL2 25348397 N/A physical interaction ComPPI
ATXN3 RDH13 25348397 N/A physical interaction ComPPI
ATXN3 SLC25A22 25348397 N/A physical interaction ComPPI
ATXN3 SDHA 25348397 N/A physical interaction ComPPI
ATXN3 SLC25A5 25348397 N/A physical interaction ComPPI
ATXN3 SFXN4 25348397 N/A physical interaction ComPPI
ATXN3 MALT1 25348397 N/A physical interaction ComPPI
ATXN3 HSPA4L 25348397 N/A physical interaction ComPPI
ATXN3 ACOT9 25348397 N/A physical interaction ComPPI
ATXN3 SLC27A4 25348397 N/A physical interaction ComPPI
ATXN3 SLC25A1 25348397 N/A physical interaction ComPPI
ATXN3 SEH1L 25348397 N/A physical interaction ComPPI
ATXN3 MRPL12 25348397 N/A physical interaction ComPPI
ATXN3 SLC25A10 25348397 N/A physical interaction ComPPI
ATXN3 IBA57 25348397 N/A physical interaction ComPPI
ATXN3 MTHFD2 25348397 N/A physical interaction ComPPI
ATXN3 SLC25A3 25348397 N/A physical interaction ComPPI
ATXN3 UBAC2 25348397 N/A physical interaction ComPPI
ATXN3 MGME1 25348397 N/A physical interaction ComPPI
ATXN3 TECR 25348397 N/A physical interaction ComPPI
ATXN3 ARFIP2 25348397 N/A physical interaction ComPPI
ATXN3 RMDN1 25348397 N/A physical interaction ComPPI
ATXN3 C8ORF82 25348397 N/A physical interaction ComPPI
ATXN3 LPCAT1 25348397 N/A physical interaction ComPPI
ATXN3 IDH3B 25348397 N/A physical interaction ComPPI
ATXN3 DDX39A 25348397 N/A physical interaction ComPPI
ATXN3 ALG1 25348397 N/A physical interaction ComPPI
ATXN3 RPLP0P6 25348397 N/A physical interaction ComPPI
ATXN3 PRPS1 25348397 N/A physical interaction ComPPI
ATXN3 RAB21 25348397 N/A physical interaction ComPPI
ATXN3 SLC16A1 25348397 N/A physical interaction ComPPI
ATXN3 GCAT 25348397 N/A physical interaction ComPPI
ATXN3 DNAJA1 25348397 N/A physical interaction ComPPI
ATXN3 NDUFA8 25348397 N/A physical interaction ComPPI
ATXN3 CISD2 25348397 N/A physical interaction ComPPI
ATXN3 HSD17B11 25348397 N/A physical interaction ComPPI
ATXN3 MCU 25348397 N/A physical interaction ComPPI
ATXN3 DDB1 25348397 N/A physical interaction ComPPI
ATXN3 MC1R 25348397 N/A physical interaction ComPPI
ATXN3 TUBB3 25348397 N/A physical interaction ComPPI
ATXN3 DYNC1H1 25348397 N/A physical interaction ComPPI
ATXN3 BECN1 25348397 N/A anti bait coimmunoprecipitation ComPPI
ATXN3 ATXN3 16525503 24234451 physical association filter binding IntAct
CSNK2A1 ATXN3 19542537 27898060 N/A N/A OmniPath
GSK3B ATXN3 17434145 21900206 27898060 N/A N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009B1FA3 ATXN3 27087310 direct interaction,inhibition N/A NPInter

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