GENE:MED13L
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | MED13L |
| FullNmae | mediator complex subunit 13L |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:22962 |
| EnsembleID | ENSG00000123066 |
| Uniprot | Q71F56 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| MED13L | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| MED13L | GO:0003712,GO:0006357,GO:0016592 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| MED13L | hsa:23389 | path:hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | MED13L | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ESR1 | MED13L | 18414489 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | MED13L | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | MED13L | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | MED13L | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| HIF1A | MED13L | 19828020 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| FOXP3 | MED13L | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | MED13L | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | MED13L | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | MED13L | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | MED13L | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | MED13L | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | MED13L | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | MED13L | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | MED13L | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | MED13L | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | MED13L | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | MED13L | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | MED13L | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | MED13L | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000272039 | MED13L | 20371350 25416803 | mrna cleavage,inhibition | nucleotide sequence identification | TarBase |
| URS0000122ED0 | MED13L | 19088304 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00000DDD35 | MED13L | 20371350 25416803 | mrna cleavage,inhibition | nucleotide sequence identification | TarBase |
| URS00003D5391 | MED13L | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000035CC3E | MED13L | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00005FDE70 | MED13L | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000183BED | MED13L | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000000B1C9 | MED13L | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00004407DC | MED13L | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000B0E50 | MED13L | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| TP53BP1 | MED13L | 24234451 25348397 29656893 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| MED21 | MED13L | 25348397 | N/A | physical interaction | ComPPI |
| FBXW7 | MED13L | 25348397 | N/A | physical interaction | ComPPI |
| HIF1A | MED13L | 23746844 24234451 25348397 | association | pull down,physical interaction | ComPPI,IntAct |
| MED1 | MED13L | 25348397 | N/A | physical interaction | ComPPI |
| SYNCRIP | MED13L | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| MED9 | MED13L | 14638676 15175163 24234451 25348397 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| MED23 | MED13L | 25348397 | N/A | physical interaction | ComPPI |
| MED28 | MED13L | 25348397 | N/A | physical interaction | ComPPI |
| MED12 | MED13L | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| CDK8 | MED13L | 23602568 24234451 25348397 26496610 29568061 | association | anti tag coimmunoprecipitation,pull down,physical interaction,tandem affinity purification,proximity-dependent biotin identification | ComPPI,IntAct |
| MED13 | MED13L | 14525934 15175163 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| TRIM25 | MED13L | 25348397 | N/A | physical interaction | ComPPI |
| SORT1 | MED13L | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| CDK19 | MED13L | 15175163 23602568 24234451 25348397 | association,physical association | physical interaction,ion exchange chromatography,tandem affinity purification | ComPPI,IntAct |
| MED19 | MED13L | 15175163 21729782 24234451 25348397 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| MED13L | MED10 | 14576168 15175163 24234451 25348397 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| MED13L | CCNC | 25348397 | N/A | physical interaction | ComPPI |
| MED13L | MED4 | 25348397 | N/A | physical interaction | ComPPI |
| MED18 | MED13L | 25348397 | N/A | physical interaction | ComPPI |
| IMMT | MED13L | 24234451 30021884 | physical association | cross-linking study | IntAct |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00009B4818 | MED13L | 27087310 | direct interaction,inhibition | N/A | NPInter |
