GENE：AMPD3
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | AMPD3 |
| FullNmae | adenosine monophosphate deaminase 3 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:470 |
| EnsembleID | ENSG00000133805 |
| Uniprot | Q01432 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| AMPD3 | pyroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| AMPD3 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| AMPD3 | GO:0003876,GO:0003876,GO:0005515,GO:0005576,GO:0005829,GO:0005829,GO:0006188,GO:0006196,GO:0032264,GO:0034774,GO:0046033,GO:0046872,GO:1904813 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| AMPD3 | hsa:272 | path:hsa00230 | Purine metabolism - Homo sapiens (human) |
| AMPD3 | hsa:272 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| AMPD3 | hsa:272 | path:hsa01232 | Nucleotide metabolism - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | AMPD3 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | AMPD3 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | AMPD3 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | AMPD3 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| MYC | AMPD3 | 12695333 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | AMPD3 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | AMPD3 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | AMPD3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | AMPD3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | AMPD3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | AMPD3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | AMPD3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | AMPD3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | AMPD3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | AMPD3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | AMPD3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PRDM14 | AMPD3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | AMPD3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | AMPD3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | AMPD3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F2 | AMPD3 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000237AF9 | AMPD3 | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS0000610EFA | AMPD3 | 23313552 23824327 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS000076B539 | AMPD3 | 23313552 23824327 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS000019F055 | AMPD3 | 23313552 23824327 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS000043D2C1 | AMPD3 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000008AA34 | AMPD3 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000118224 | AMPD3 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002C02E4 | AMPD3 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000015188E | AMPD3 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002CE0C6 | AMPD3 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002004E0 | AMPD3 | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS00001919B0 | AMPD3 | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| HSPA8 | AMPD3 | 24234451 25348397 25910212 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| RAD21 | AMPD3 | 25348397 | N/A | physical interaction | ComPPI |
| HSP90AB1 | AMPD3 | 24234451 25348397 25910212 | association,physical association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| ALB | AMPD3 | 15174051 24234451 25348397 | association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| H2BC9 | AMPD3 | 24234451 30021884 | physical association | cross-linking study | IntAct |
| H3-4 | AMPD3 | 24234451 30021884 | physical association | cross-linking study | IntAct |