Gene Information gene info

GENE:LRRC8E

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol LRRC8E
FullNmae leucine rich repeat containing 8 VRAC subunit E
LocusType gene with protein product
Status Approved
HGNC_id HGNC:26272
EnsembleID ENSG00000171017
Uniprot Q6NSJ5

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
LRRC8E immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
LRRC8E autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
LRRC8E GO:0005225,GO:0005225,GO:0005515,GO:0005737,GO:0005765,GO:0005789,GO:0005886,GO:0005886,GO:0005886,GO:0006884,GO:0007165,GO:0015810,GO:0034702,GO:0071470,GO:0098656,GO:0140361

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TFAP2C LRRC8E 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CEBPA LRRC8E 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS LRRC8E 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A LRRC8E 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 LRRC8E 19088304 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
PTGIR LRRC8E 25348397 N/A physical interaction ComPPI
GPSM2 LRRC8E 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LGALS8 LRRC8E 25348397 N/A physical interaction ComPPI
TRIM25 LRRC8E 25348397 N/A physical interaction ComPPI
ESR2 LRRC8E 24234451 25348397 25604459 association tandem affinity purification ComPPI,IntAct
LNX2 LRRC8E 25348397 N/A physical interaction ComPPI
TBC1D4 LRRC8E 25348397 N/A physical interaction ComPPI
TRMT6 LRRC8E 25348397 N/A physical interaction ComPPI
DMD LRRC8E 25348397 N/A physical interaction ComPPI
NXF1 LRRC8E 25348397 N/A physical interaction ComPPI
MOV10 LRRC8E 25348397 N/A physical interaction ComPPI
PPME1 LRRC8E 25348397 N/A physical interaction ComPPI
DDHD2 LRRC8E 25348397 N/A physical interaction ComPPI
LRRC8E PGAM5 24234451 30021884 physical association cross-linking study IntAct

Visualization