Gene Information gene info

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GENE：CYTH2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CYTH2
FullNmae cytohesin 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9502
EnsembleID ENSG00000105443
Uniprot Q99418

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CYTH2 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CYTH2 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CYTH2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
CYTH2 GO:0000139,GO:0005085,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0005912,GO:0005923,GO:0006897,GO:0008289,GO:0016020,GO:0030036,GO:0030426,GO:0032012,GO:0070679

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CYTH2 hsa:9266 path:hsa04072 Phospholipase D signaling pathway - Homo sapiens (human)
CYTH2 hsa:9266 path:hsa04144 Endocytosis - Homo sapiens (human)
CYTH2 hsa:9266 path:hsa05130 Pathogenic Escherichia coli infection - Homo sapiens (human)
CYTH2 hsa:9266 path:hsa05131 Shigellosis - Homo sapiens (human)
CYTH2 hsa:9266 path:hsa05132 Salmonella infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ITGB2 CYTH2 23180781 8706128 physical association two hybrid InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 CYTH2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 CYTH2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 CYTH2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 CYTH2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 CYTH2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS CYTH2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 CYTH2 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00002B2B5C CYTH2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00004929F1 CYTH2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00002373FD CYTH2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000055929F CYTH2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00000CC005 CYTH2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00000EC1BE CYTH2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00000C85B2 CYTH2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002FC5B0 CYTH2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000B989F CYTH2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000021202F CYTH2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000013DD8 CYTH2 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00001A7F58 CYTH2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001C770D CYTH2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00002152A8 CYTH2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000AB32B CYTH2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075A760 CYTH2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000007F792 CYTH2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000AD002 CYTH2 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKCA CYTH2 22135298 phosphorylation N/A PhosphoSite
AKT1 CYTH2 22135298 phosphorylation N/A PhosphoSite
PRKCG CYTH2 25361965 interaction type N/A PTMCode2
CYTH2 PRKCG 25361965 interaction type N/A PTMCode2
ITGB2 CYTH2 25361965 interaction type N/A PTMCode2
CYTH2 ITGB2 25361965 interaction type N/A PTMCode2
EGFR CYTH2 25361965 interaction type N/A PTMCode2
CYTH2 EGFR 25361965 interaction type N/A PTMCode2
ARF1 CYTH2 25361965 interaction type N/A PTMCode2
CYTH2 ARF1 25361965 interaction type N/A PTMCode2
TRIM23 CYTH2 25361965 interaction type N/A PTMCode2
CYTH2 TRIM23 25361965 interaction type N/A PTMCode2
IPCEF1 CYTH2 25361965 interaction type N/A PTMCode2
CYTH2 IPCEF1 25361965 interaction type N/A PTMCode2
ARRB2 CYTH2 25361965 interaction type N/A PTMCode2
CYTH2 ARRB2 25361965 interaction type N/A PTMCode2
ARF6 CYTH2 25361965 interaction type N/A PTMCode2
CYTH2 ARF6 25361965 interaction type N/A PTMCode2
ARRB1 CYTH2 25361965 interaction type N/A PTMCode2
CYTH2 ARRB1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
ARL4A CYTH2 25348397 N/A physical interaction ComPPI
DDIT4L CYTH2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PRKCA CYTH2 10531036 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
GRB2 CYTH2 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
FOSL2 CYTH2 25348397 N/A physical interaction ComPPI
PIK3CA CYTH2 25348397 N/A physical interaction ComPPI
GNAQ CYTH2 25348397 N/A physical interaction ComPPI
APC CYTH2 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
PRKCB CYTH2 10531036 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ITGB2 CYTH2 25348397 N/A two hybrid,in vitro,in vivo ComPPI
CYTH2 PRKCG 10531036 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
CYTH2 ARRB1 11533043 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CYTH2 ARRB2 11533043 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CYTH2 ARF6 14525934 24234451 25348397 27265506 9417041 N/A experimental interaction detection,physical interaction,in vitro,in vivo,gdp/gtp exchange assay ComPPI,HPRD,IntAct
CYTH2 ARFGAP1 14525934 25348397 27898060 9476900 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
CYTH2 CUX1 25348397 N/A two hybrid,in vitro,in vivo ComPPI
CYTH2 TRIM23 10748148 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
CYTH2 ADORA2A 14525934 16027149 24234451 25348397 27898060 colocalization,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,fluorescent resonance energy transfer,pull down,physical interaction,in vitro,in vivo,confocal microscopy,two hybrid ComPPI,HPRD,IntAct,OmniPath
CYTH2 IPCEF1 12920129 14525934 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vitro,in vivo,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
CYTH2 CCDC120 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
CYTH2 CYTIP 12606567 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CYTH2 ATP6V0A2 14525934 16415858 24234451 25348397 physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
CYTH2 ARF1 10198630 14525934 14654833 17563369 24234451 25348397 9417041 physical association classical fluorescence spectroscopy,experimental interaction detection,x-ray crystallography,physical interaction,biochemical,in vitro,in vivo ComPPI,HPRD,IntAct
CYTH2 SFN 15778465 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
CYTH2 PNPLA2 25348397 N/A physical interaction ComPPI
CYTH2 MTMR7 25348397 N/A physical interaction ComPPI
CYTH2 CNKSR1 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CYTH2 INAVA 24234451 25348397 29420262 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CYTH2 CCDC40 25348397 N/A physical interaction ComPPI
CYTH2 GGA3 25348397 N/A physical interaction ComPPI
CYTH2 MYD88 25348397 N/A anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI
CYTH2 INSR 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
CYTH2 IRS1 17167487 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MAPK6 CYTH2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ARL4D CYTH2 25348397 N/A physical interaction ComPPI
CYTH2 CUX1 12052827 14525934 27898060 N/A experimental interaction detection,two hybrid HPRD,OmniPath
PRKCA CYTH2 10531036 18042453 20153292 24083777 27898060 inhibition N/A OmniPath
PRKCB CYTH2 10531036 27898060 inhibition N/A OmniPath
AKT1 CYTH2 24303080 27898060 N/A N/A OmniPath
PRKCG CYTH2 10531036 27898060 inhibition N/A OmniPath
PASK CYTH2 10531036 27898060 N/A N/A OmniPath

Visualization










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