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GENE：DARS2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol DARS2
FullNmae aspartyl-tRNA synthetase 2, mitochondrial
LocusType gene with protein product
Status Approved
HGNC_id HGNC:25538
EnsembleID ENSG00000117593
Uniprot Q6PI48

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
DARS2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
DARS2 GO:0000049,GO:0004815,GO:0004815,GO:0005515,GO:0005524,GO:0005654,GO:0005739,GO:0005739,GO:0005739,GO:0005759,GO:0006422,GO:0042803,GO:0043039,GO:0050560,GO:0070145,GO:0070145

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
DARS2 hsa:55157 path:hsa00970 Aminoacyl-tRNA biosynthesis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR DARS2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 DARS2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 DARS2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 DARS2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 DARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF DARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 DARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR DARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000065D58 DARS2 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS000021D7C8 DARS2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000153377 DARS2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000259AE4 DARS2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00003E2232 DARS2 24906430 25416803 mrna cleavage,inhibition clip TarBase
URS000031B6ED DARS2 24906430 25416803 mrna cleavage,inhibition clip TarBase
URS00000EE7F0 DARS2 24906430 25416803 mrna cleavage,inhibition clip TarBase
URS000030F801 DARS2 24906430 25416803 mrna cleavage,inhibition clip TarBase
URS00000011DF DARS2 24906430 25416803 mrna cleavage,inhibition clip TarBase
URS00000AD002 DARS2 24906430 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 DARS2 19536157 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001EFBE3 DARS2 19536157 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000EBD4B DARS2 19536157 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000043C1C3 DARS2 19536157 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005CC20C DARS2 19536157 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000BA274 DARS2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004B4B85 DARS2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075D2F5 DARS2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000006372A DARS2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00003D4175 DARS2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00003FBC84 DARS2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000027352D DARS2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E DARS2 25416803 28735896 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
AIMP2 DARS2 25348397 N/A physical interaction ComPPI
NTRK1 DARS2 25348397 N/A physical interaction ComPPI
PLAUR DARS2 25348397 N/A physical interaction ComPPI
EPHA8 DARS2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RPA2 DARS2 25348397 N/A physical interaction ComPPI
DPYSL5 DARS2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PLP2 DARS2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PDK1 DARS2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
FOXH1 DARS2 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
FNTA DARS2 25348397 N/A physical interaction ComPPI
KARS1 DARS2 25348397 N/A physical interaction ComPPI
DCP2 DARS2 25348397 N/A physical interaction ComPPI
TERF2 DARS2 25348397 N/A physical interaction ComPPI
FOXL2 DARS2 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
HSPD1 DARS2 24234451 25348397 29568061 30021884 association,physical association cross-linking study,physical interaction,proximity-dependent biotin identification ComPPI,IntAct
SLC25A10 DARS2 25348397 N/A physical interaction ComPPI
AIFM1 DARS2 24234451 25348397 29568061 association pull down ComPPI,IntAct
MRPL12 DARS2 25348397 N/A physical interaction ComPPI
GAPDHS DARS2 25348397 N/A physical interaction ComPPI
TRMT61B DARS2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct

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