GENE：PI4K2A
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | PI4K2A |
| FullNmae | phosphatidylinositol 4-kinase type 2 alpha |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:30031 |
| EnsembleID | ENSG00000155252 |
| Uniprot | Q9BTU6 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| PI4K2A | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| PI4K2A | GO:0000139,GO:0000287,GO:0004430,GO:0004430,GO:0004430,GO:0005515,GO:0005524,GO:0005739,GO:0005765,GO:0005768,GO:0005768,GO:0005802,GO:0005829,GO:0005886,GO:0005886,GO:0006661,GO:0006661,GO:0007030,GO:0007032,GO:0016020,GO:0016020,GO:0016310,GO:0030425,GO:0031410,GO:0031901,GO:0035651,GO:0035838,GO:0042734,GO:0043005,GO:0043025,GO:0043204,GO:0045121,GO:0046854,GO:0046854 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| PI4K2A | hsa:55361 | path:hsa00562 | Inositol phosphate metabolism - Homo sapiens (human) |
| PI4K2A | hsa:55361 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| PI4K2A | hsa:55361 | path:hsa04070 | Phosphatidylinositol signaling system - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | PI4K2A | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | PI4K2A | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| YBX1 | PI4K2A | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | PI4K2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | PI4K2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | PI4K2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | PI4K2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | PI4K2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | PI4K2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | PI4K2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | PI4K2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| VDR | PI4K2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | PI4K2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000070B1D | PI4K2A | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000018CD09 | PI4K2A | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000003575B | PI4K2A | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000029D9F1 | PI4K2A | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000044FD7 | PI4K2A | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| NOS3 | PI4K2A | 21163940 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| CD7 | PI4K2A | 25348397 | N/A | physical interaction | ComPPI |
| HSP90AA1 | PI4K2A | 25348397 | N/A | physical interaction | ComPPI |
| PVR | PI4K2A | 25348397 | N/A | physical interaction | ComPPI |
| RAD23A | PI4K2A | 21163940 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| GABARAP | PI4K2A | 20562859 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| ITCH | PI4K2A | 23146885 24234451 25348397 | colocalization,physical association | nuclear magnetic resonance,pull down,fluorescence microscopy | ComPPI,IntAct |
| FANCE | PI4K2A | 25348397 | N/A | physical interaction | ComPPI |
| ECSIT | PI4K2A | 25348397 | N/A | physical interaction | ComPPI |
| TNFRSF10A | PI4K2A | 25348397 | N/A | physical interaction | ComPPI |
| CLTB | PI4K2A | 25348397 | N/A | physical interaction | ComPPI |
| CNOT1 | PI4K2A | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| KIF11 | PI4K2A | 25348397 | N/A | physical interaction | ComPPI |
| CD63 | PI4K2A | 11113129 14525934 25348397 27898060 9006891 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD,OmniPath |
| PI4K2A | APP | 25348397 | N/A | physical interaction | ComPPI |
| PI4K2A | PHF8 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| PI4K2A | TPCN2 | 25348397 | N/A | physical interaction | ComPPI |
| PI4K2A | KIF3A | 25348397 | N/A | physical interaction | ComPPI |
| PI4K2A | CLSPN | 18082599 27898060 | inhibition | N/A | OmniPath |