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GENE：TPP1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TPP1
FullNmae tripeptidyl peptidase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2073
EnsembleID ENSG00000166340
Uniprot O14773

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TPP1 lysosomal_cd 36341760 220 lysosome-dependent cell death genes. retulator signature
TPP1 lysosomal_cd 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
TPP1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
TPP1 GO:0004175,GO:0004175,GO:0004175,GO:0004252,GO:0005515,GO:0005764,GO:0005764,GO:0005794,GO:0006508,GO:0006508,GO:0006629,GO:0007040,GO:0007399,GO:0007417,GO:0008233,GO:0008236,GO:0008240,GO:0008240,GO:0008240,GO:0030163,GO:0030855,GO:0035727,GO:0042277,GO:0042470,GO:0043171,GO:0043202,GO:0045121,GO:0045453,GO:0046872,GO:0050885,GO:0055037,GO:0070062,GO:0070198,GO:0120146,GO:1905146

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TPP1 hsa:1200 path:hsa04142 Lysosome - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CIITA TPP1 18437201 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 TPP1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 TPP1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 TPP1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 TPP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TPP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 TPP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS TPP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF TPP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 TPP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000070B1D TPP1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003E5ECC TPP1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000014F13C TPP1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000279B6F TPP1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000AD002 TPP1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000544FF1 TPP1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000015A0D9 TPP1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075C4B1 TPP1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00004ACAAA TPP1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000527B00 TPP1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075C1E1 TPP1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000031602A TPP1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000251D0B TPP1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001C11BC TPP1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002C0FCB TPP1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000315338 TPP1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000032015F TPP1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000116F83 TPP1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001A7F58 TPP1 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CDK1 TPP1 22135298 phosphorylation N/A PhosphoSite
WIPI1 TPP1 25361965 interaction type N/A PTMCode2
TPP1 WIPI1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
MCM2 TPP1 25348397 N/A physical interaction ComPPI
STN1 TPP1 25348397 N/A anti tag coimmunoprecipitation,two hybrid,physical interaction,physical interaction ComPPI
USP7 TPP1 25348397 N/A physical interaction ComPPI
MYC TPP1 21150319 24234451 25348397 association tandem affinity purification ComPPI,IntAct
TERT TPP1 17237767 24234451 25348397 physical association molecular sieving,pull down,physical interaction,in vivo ComPPI,IntAct
ANG TPP1 24234451 25348397 28777577 association anti bait coimmunoprecipitation ComPPI,IntAct
ABCE1 TPP1 25348397 N/A physical interaction ComPPI
EGFR TPP1 25348397 N/A physical interaction ComPPI
HTT TPP1 17500595 24234451 25348397 association pull down ComPPI,IntAct
HNRNPH1 TPP1 25348397 N/A physical interaction ComPPI
POT1 TPP1 25348397 N/A anti tag coimmunoprecipitation,physical interaction,physical interaction ComPPI
TINF2 TPP1 25348397 N/A physical interaction ComPPI
CDC25C TPP1 25348397 N/A physical interaction ComPPI
TOMM20 TPP1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
DNAJA1 TPP1 25348397 N/A physical interaction ComPPI
RPTOR TPP1 25348397 N/A physical interaction ComPPI
NLRP2 TPP1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
A2M TPP1 17174955 24234451 25348397 colocalization cosedimentation through density gradient ComPPI,IntAct
CCDC88A TPP1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NME4 TPP1 25348397 N/A physical interaction ComPPI
FBXO6 TPP1 25348397 N/A physical interaction ComPPI
TPP1 NMB 14525934 15158442 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
TPP1 CTC1 25348397 N/A anti tag coimmunoprecipitation,two hybrid,physical interaction,physical interaction ComPPI
TPP1 OMA1 25348397 N/A physical interaction ComPPI
TPP1 SLC25A16 25348397 N/A physical interaction ComPPI
TPP1 BCAR1 24234451 25348397 28007913 association anti bait coimmunoprecipitation ComPPI,IntAct
HSCB TPP1 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct
TPP1 SKP1 27898060 9346238 9819356 N/A N/A OmniPath
TPP1 RNF8 22101936 27898060 N/A N/A OmniPath

Visualization










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