GENE：LCAT
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | LCAT |
| FullNmae | lecithin-cholesterol acyltransferase |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:6522 |
| EnsembleID | ENSG00000213398 |
| Uniprot | P04180 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| LCAT | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| LCAT | GO:0003847,GO:0004607,GO:0004607,GO:0004607,GO:0004607,GO:0004771,GO:0005515,GO:0005576,GO:0005615,GO:0005615,GO:0006629,GO:0006644,GO:0006656,GO:0006656,GO:0008203,GO:0030301,GO:0034186,GO:0034364,GO:0034372,GO:0034375,GO:0034375,GO:0042158,GO:0042632,GO:0043691,GO:0046470,GO:0047179,GO:0070062,GO:0090107 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| LCAT | hsa:3931 | path:hsa00564 | Glycerophospholipid metabolism - Homo sapiens (human) |
| LCAT | hsa:3931 | path:hsa04979 | Cholesterol metabolism - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SP1 | LCAT | 9610763 | trascriptional regulation,stimulation | inferred by curator,electrophoretic mobility shift assay | TFlink |
| SP3 | LCAT | 9610763 | trascriptional regulation,stimulation | inferred by curator,electrophoretic mobility shift assay | TFlink |
| CTCF | LCAT | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | LCAT | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | LCAT | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| DAND5 | LCAT | 9610763 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| STAT3 | LCAT | 12032172 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| APOA2 | LCAT | 25348397 | N/A | physical interaction | ComPPI |
| APOA1 | LCAT | 14525934 1587806 1644835 17676061 24234451 25348397 | N/A | affinity chromatography technology,experimental interaction detection,mass spectrometry studies of complexes,physical interaction,in vivo | ComPPI,HPRD,IntAct |
| APOE | LCAT | 25348397 | N/A | physical interaction | ComPPI |
| EXOSC10 | LCAT | 25348397 | N/A | physical interaction | ComPPI |
| LCAT | A2M | 11435418 14525934 25348397 27898060 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD,OmniPath |
| LCAT | PIKFYVE | 25348397 | N/A | physical interaction | ComPPI |
| PRKCA | LCAT | 27898060 3128170 | N/A | N/A | OmniPath |
| APOA1 | LCAT | 10026251 10222237 15654758 1587806 1644835 17676061 19860440 27898060 3104518 4335615 | stimulant | N/A | OmniPath |