Gene Information gene info

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GENE：ORC1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ORC1
FullNmae origin recognition complex subunit 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8487
EnsembleID ENSG00000085840
Uniprot Q13415

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ORC1 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ORC1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ORC1 GO:0000781,GO:0000781,GO:0000808,GO:0003677,GO:0003682,GO:0003688,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005654,GO:0005664,GO:0005664,GO:0005664,GO:0005829,GO:0006270,GO:0006270,GO:0016887,GO:0033314,GO:0046872

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ORC1 hsa:4998 path:hsa04110 Cell cycle - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CDT1 ORC1 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
MCM2 ORC1 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
MCM3 ORC1 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
MCM4 ORC1 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
MCM7 ORC1 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC1 CDC45 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC1 CDC6 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC1 MCM5 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC1 MCM6 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC1 ORC3 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC1 ORC6 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC2 ORC1 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC4 ORC1 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC5 ORC1 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
CDK2 ORC1 14536078 15147722 15175241 15279786 15677884 16581787 17038621 17102137 17116885 17296725 17303408 17582221 17660363 17713585 18590585 18636226 19793801 26192618 7575488 interaction type N/A ACSN
CDC7 ORC1 15279786 17018296 17102137 17116885 17296725 17303408 17582221 17660363 18590585 19793801 26192618 7575488 interaction type N/A ACSN
DBF4 ORC1 15279786 17018296 17102137 17116885 17296725 17303408 17582221 17660363 18590585 19793801 26192618 7575488 interaction type N/A ACSN
RPA1 ORC1 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258 26192618 interaction type N/A ACSN
RPA2 ORC1 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258 26192618 interaction type N/A ACSN
RPA3 ORC1 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258 26192618 interaction type N/A ACSN
HUS1 ORC1 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16885023 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 26192618 8943031 9524127 interaction type N/A ACSN
RAD1 ORC1 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16885023 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 26192618 8943031 9524127 interaction type N/A ACSN
RAD17 ORC1 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16885023 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 26192618 8943031 9524127 interaction type N/A ACSN
CDK1 ORC1 14551205 15279786 17102137 17116885 17296725 17303408 17582221 17660363 18414028 18590585 19793801 26192618 7575488 interaction type N/A ACSN
ATRIP ORC1 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 26192618 8943031 9524127 association N/A ACSN
ATR ORC1 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 26192618 8943031 9524127 association N/A ACSN
CHEK1 ORC1 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 26192618 8943031 9524127 association N/A ACSN
CLSPN ORC1 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 26192618 8943031 9524127 association N/A ACSN
TIPIN ORC1 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 26192618 8943031 9524127 association N/A ACSN

Source Target Pmid Interactiontype Methods Database
GATA2 ORC1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 ORC1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 ORC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000F31F4 ORC1 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 ORC1 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00001A7F58 ORC1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003CF1AD ORC1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000075D814 ORC1 21572407 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000075CC78 ORC1 21572407 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001C0099 ORC1 21572407 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000015A0D9 ORC1 21572407 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001012BC ORC1 21572407 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000331800 ORC1 21572407 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002B0920 ORC1 21572407 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00003AD2AA ORC1 21572407 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000003FD55 ORC1 21572407 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000075BDAA ORC1 21572407 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000021202F ORC1 21572407 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00004AC389 ORC1 21572407 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000075E2C3 ORC1 21572407 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000016D2D4 ORC1 21572407 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00005D986D ORC1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 ORC1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000045DBD ORC1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 ORC1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000315338 ORC1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00002C0FCB ORC1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001C11BC ORC1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000251D0B ORC1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000048D44E ORC1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000221168 ORC1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000031602A ORC1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00005CC20C ORC1 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CDK2 ORC1 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
GOLGA2 ORC1 25348397 N/A two hybrid,physical interaction ComPPI
ORC1 ORC2 11779870 11931757 14525934 15232106 16549788 17716973 22398447 24234451 25348397 26496610 association,physical association anti tag coimmunoprecipitation,coimmunoprecipitation,cosedimentation through density gradient,experimental interaction detection,protein array,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
ORC1 SKP2 11931757 14525934 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
ORC1 XPO1 11716535 14525934 25348397 27898060 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
ORC1 CDC6 12912926 14525934 15232106 24234451 25348397 9566895 N/A experimental interaction detection,protein array,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
ORC1 MCM5 14525934 15232106 24234451 25348397 N/A experimental interaction detection,protein array,physical interaction,in vitro ComPPI,HPRD,IntAct
ORC1 ORC3 14525934 15232106 16549788 17716973 22398447 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,cosedimentation through density gradient,experimental interaction detection,protein array,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
ORC1 CDT1 14525934 15232106 24234451 25348397 N/A experimental interaction detection,protein array,physical interaction,in vitro ComPPI,HPRD,IntAct
ORC1 KAT7 10438470 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
ORC1 ORC5 14525934 15232106 16549788 17716973 22398447 24234451 25348397 26496610 association,physical association anti tag coimmunoprecipitation,cosedimentation through density gradient,experimental interaction detection,protein array,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
ORC1 CDC7 12614612 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
ORC1 MCM2 12614612 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
ORC1 CDC5L 14525934 15232106 24234451 25348397 N/A experimental interaction detection,protein array,physical interaction,in vitro ComPPI,HPRD,IntAct
ORC1 CDK2 11931757 14525934 24234451 25348397 association coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
ORC1 MCM7 12614612 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
ORC1 ORC4 16549788 17716973 24234451 25348397 26496610 association,physical association anti tag coimmunoprecipitation,cosedimentation through density gradient,pull down,physical interaction ComPPI,IntAct
ORC1 MCM4 25348397 N/A physical interaction ComPPI
ORC1 MCM6 25348397 N/A physical interaction ComPPI
ORC1 DBF4 25348397 N/A physical interaction ComPPI
ORC1 CDC45 25348397 N/A physical interaction ComPPI
ORC1 RPA2 25348397 N/A physical interaction ComPPI
ORC1 XRCC5 25348397 N/A physical interaction ComPPI
ORC1 CCNA2 11931757 24234451 25348397 26496610 association anti tag coimmunoprecipitation,coimmunoprecipitation,physical interaction ComPPI,IntAct
ORC1 TERF2 16799465 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
ORC1 MGMT 25348397 N/A physical interaction ComPPI
ORC1 CIRBP 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ORC1 LRWD1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ORC1 RFC3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ORC1 SRP72 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ORC1 ELOB 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ORC1 TRIM26 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ORC1 ZNF174 25348397 N/A physical interaction ComPPI
ORC1 SCAMP3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ORC1 CDIPT 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ORC1 EXOSC2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ORC1 HARS2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ORC1 PHF3 25348397 N/A physical interaction ComPPI
ORC1 DIMT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ORC1 LARP7 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ORC1 POLE3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ORC1 PHIP 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ORC1 MRM3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ORC1 CHMP1B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ORC1 MRPS15 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ORC1 MRPL11 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ORC1 ZNF768 25348397 N/A physical interaction ComPPI
ORC1 PHF6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ORC1 DOT1L 25348397 N/A physical interaction ComPPI
ORC1 HMGA1 18234858 24234451 25348397 N/A physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
ORC1 CBX5 20689044 24234451 25348397 N/A pull down,physical interaction ComPPI,IntAct
ORC1 CCNA1 11931757 24234451 25348397 association coimmunoprecipitation ComPPI,IntAct
ORC1 UBB 11931757 24234451 25348397 physical association coimmunoprecipitation ComPPI,IntAct
ORC1 ABL1 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
ORC1 FYN 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
ORC1 TSG101 19549727 24234451 25348397 physical association two hybrid ComPPI,IntAct
ORC1 GOLGA6L9 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ORC1 SU(VAR)205 24234451 25348397 physical association experimental interaction detection ComPPI,IntAct
ORC1 TRIP13 21822291 27898060 N/A N/A OmniPath
CDK2 ORC1 11931757 19413330 20068231 27898060 N/A N/A OmniPath
CDK1 ORC1 11931757 21289063 27898060 stimulant N/A OmniPath

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