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GENE：UBE2A

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol UBE2A
FullNmae ubiquitin conjugating enzyme E2 A
LocusType gene with protein product
Status Approved
HGNC_id HGNC:12472
EnsembleID ENSG00000077721
Uniprot P49459

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
UBE2A autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
UBE2A GO:0000086,GO:0000209,GO:0000785,GO:0004842,GO:0005515,GO:0005524,GO:0005654,GO:0005829,GO:0006281,GO:0006281,GO:0006301,GO:0006338,GO:0006511,GO:0009411,GO:0016574,GO:0031625,GO:0033503,GO:0033503,GO:0043130,GO:0043161,GO:0061631,GO:0061631,GO:0070936,GO:0070979,GO:0140852

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
UBE2A hsa:7319 path:hsa04120 Ubiquitin mediated proteolysis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 UBE2A 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
CTCF UBE2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 UBE2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002971AB UBE2A 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000EC1BE UBE2A 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000324096 UBE2A 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003AD231 UBE2A 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002E92A8 UBE2A 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00005194EC UBE2A 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000006FDD4 UBE2A 21572407 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CDK1 UBE2A 22135298 phosphorylation N/A PhosphoSite
CDK2 UBE2A 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
PIN1 UBE2A 25348397 N/A physical interaction ComPPI
GNAI3 UBE2A 25348397 N/A physical interaction ComPPI
KRT6B UBE2A 25348397 N/A physical interaction ComPPI
SNRPB UBE2A 25348397 N/A physical interaction ComPPI
CDC73 UBE2A 19410543 24234451 25348397 association pull down ComPPI,IntAct
RNF40 UBE2A 19410543 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
ZBED1 UBE2A 25348397 N/A physical interaction ComPPI
HNRNPC UBE2A 25348397 N/A physical interaction ComPPI
KRT19 UBE2A 25348397 N/A physical interaction ComPPI
DHX15 UBE2A 25348397 N/A physical interaction ComPPI
KRT5 UBE2A 25348397 N/A physical interaction ComPPI
PCNA UBE2A 25348397 N/A physical interaction ComPPI
EMD UBE2A 25348397 N/A physical interaction ComPPI
HAT1 UBE2A 19549727 24234451 25348397 physical association two hybrid ComPPI,IntAct
GSTP1 UBE2A 25348397 N/A physical interaction ComPPI
FBXO17 UBE2A 25348397 N/A physical interaction ComPPI
XIAP UBE2A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
H2BC4 UBE2A 25348397 N/A physical interaction ComPPI
ZNF512B UBE2A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KEAP1 UBE2A 25348397 N/A physical interaction ComPPI
MYL6B UBE2A 25348397 N/A physical interaction ComPPI
PSMB2 UBE2A 25348397 N/A physical interaction ComPPI
RPL10A UBE2A 25348397 N/A physical interaction ComPPI
NF2 UBE2A 25348397 N/A physical interaction ComPPI
CD2AP UBE2A 25348397 N/A physical interaction ComPPI
CD59 UBE2A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NONO UBE2A 25348397 N/A physical interaction ComPPI
SFPQ UBE2A 25348397 N/A physical interaction ComPPI
CPNE2 UBE2A 25348397 N/A physical interaction ComPPI
UBE2L3 UBE2A 25348397 N/A physical interaction ComPPI
EIF5B UBE2A 25348397 N/A physical interaction ComPPI
ARHGEF2 UBE2A 25348397 N/A physical interaction ComPPI
DOCK7 UBE2A 25348397 N/A physical interaction ComPPI
U2AF2 UBE2A 25348397 N/A physical interaction ComPPI
TTN UBE2A 25348397 N/A physical interaction ComPPI
PEX2 UBE2A 19410543 24234451 25348397 association pull down ComPPI,IntAct
ABCD3 UBE2A 25348397 N/A physical interaction ComPPI
PFN1 UBE2A 25348397 N/A physical interaction ComPPI
CDKN2A UBE2A 25348397 N/A physical interaction,in vivo ComPPI
UBB UBE2A 25348397 N/A physical interaction,fluorescence microscopy ComPPI
UBC UBE2A 25348397 N/A physical interaction,physical interaction,fluorescence microscopy ComPPI
RPS27A UBE2A 25348397 N/A physical interaction,fluorescence microscopy ComPPI
UBA52 UBE2A 25348397 N/A physical interaction,physical interaction,fluorescence microscopy ComPPI
YBX1 UBE2A 25348397 N/A physical interaction ComPPI
AP1M1 UBE2A 25348397 N/A physical interaction ComPPI
BUB3 UBE2A 25348397 N/A physical interaction ComPPI
SSBP1 UBE2A 25348397 N/A physical interaction ComPPI
XRN2 UBE2A 25348397 N/A physical interaction ComPPI
CSNK2A1 UBE2A 25348397 N/A physical interaction ComPPI
HDLBP UBE2A 25348397 N/A physical interaction ComPPI
DCTN1 UBE2A 25348397 N/A physical interaction ComPPI
UBR5 UBE2A 25348397 N/A physical interaction ComPPI
TPR UBE2A 25348397 N/A physical interaction ComPPI
RNF123 UBE2A 25348397 N/A physical interaction ComPPI
EIF3C UBE2A 25348397 N/A physical interaction ComPPI
CTR9 UBE2A 19410543 24234451 25348397 association pull down ComPPI,IntAct
RAD18 UBE2A 10884424 10908344 14525934 19549727 24234451 25348397 26496610 association,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vivo,two hybrid ComPPI,HPRD,IntAct
UBE2B UBE2A 25348397 N/A physical interaction ComPPI
UBR2 UBE2A 25348397 N/A physical interaction ComPPI
EIF3F UBE2A 25348397 N/A physical interaction ComPPI
SDCBP UBE2A 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TNIK UBE2A 25348397 N/A physical interaction ComPPI
H2BC21 UBE2A 25348397 N/A physical interaction ComPPI
RPA2 UBE2A 25348397 N/A physical interaction ComPPI
RPA3 UBE2A 25348397 N/A physical interaction ComPPI
RBBP4 UBE2A 25348397 N/A physical interaction ComPPI
UBQLN2 UBE2A 25348397 N/A physical interaction ComPPI
RPL12 UBE2A 25348397 N/A physical interaction ComPPI
HNRNPA2B1 UBE2A 25348397 N/A physical interaction ComPPI
MDM2 UBE2A 12640129 14525934 25348397 N/A coimmunoprecipitation,experimental interaction detection,physical interaction,fluorescence microscopy,in vivo ComPPI,HPRD
SON UBE2A 25348397 N/A physical interaction ComPPI
SPTA1 UBE2A 25348397 N/A physical interaction ComPPI
SPTBN2 UBE2A 25348397 N/A physical interaction ComPPI
OBSCN UBE2A 25348397 N/A physical interaction ComPPI
CDK2 UBE2A 11953320 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CBX5 UBE2A 25348397 N/A physical interaction ComPPI
SYNCRIP UBE2A 25348397 N/A physical interaction ComPPI
ANXA2 UBE2A 25348397 N/A physical interaction ComPPI
CCNT1 UBE2A 25348397 N/A physical interaction ComPPI
UBQLN4 UBE2A 25348397 N/A physical interaction ComPPI
PPP2R2A UBE2A 25348397 N/A physical interaction ComPPI
EIF5A UBE2A 25348397 N/A physical interaction ComPPI
TAX1BP1 UBE2A 25348397 N/A physical interaction ComPPI
UBE2A ZMYM2 12776193 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
UBE2A TP53 12640129 14525934 25348397 N/A coimmunoprecipitation,experimental interaction detection,physical interaction,fluorescence microscopy,surface plasmon resonance array ComPPI,HPRD
UBE2A CDKN2A 25348397 N/A coimmunoprecipitation,physical interaction,physical interaction ComPPI
UBE2A UBR3 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2A TRIM27 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2A NBN 25348397 N/A physical interaction ComPPI
UBE2A CRMP1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
UBE2A UBR1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
UBE2A CDK9 25348397 N/A physical interaction ComPPI
UBE2A SHPRH 25348397 N/A physical interaction ComPPI
UBE2A UBA1 25348397 N/A physical interaction ComPPI
UBE2A UBQLN1 25348397 N/A physical interaction ComPPI
UBE2A TWF1 25348397 N/A physical interaction ComPPI
UBE2A UBE2V1 25348397 N/A physical interaction ComPPI
UBE2A UNK 25348397 N/A physical interaction ComPPI
UBE2A ZPR1 25348397 N/A physical interaction ComPPI
UBE2A CSE1L 25348397 N/A physical interaction ComPPI
UBE2A UCHL3 25348397 N/A physical interaction ComPPI
UBE2A TYMS 25348397 N/A physical interaction ComPPI
UBE2A SULT1A1 25348397 N/A physical interaction ComPPI
UBE2A ZWILCH 25348397 N/A physical interaction ComPPI
UBE2A ZFYVE19 25348397 N/A physical interaction ComPPI
UBE2A TTLL12 25348397 N/A physical interaction ComPPI
UBE2A USP1 25348397 N/A physical interaction ComPPI
UBE2A PRDX5 25348397 N/A physical interaction ComPPI
UBE2A POMP 25348397 N/A physical interaction ComPPI
UBE2A HLTF 25348397 N/A physical interaction ComPPI
UBE2A SLF1 25348397 N/A physical interaction ComPPI
UBE2A WAC 25348397 N/A physical interaction ComPPI
UBE2A KCMF1 25348397 N/A physical interaction ComPPI
UBE2A UBR4 19549727 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
UBE2A NIPSNAP1 25348397 N/A physical interaction ComPPI
UBE2A ABHD10 25348397 N/A physical interaction ComPPI
UBE2A SARS2 25348397 N/A physical interaction ComPPI
UBE2A ACOT9 25348397 N/A physical interaction ComPPI
UBE2A KIF2C 25348397 N/A physical interaction ComPPI
UBE2A PRPF19 25348397 N/A physical interaction ComPPI
UBE2A UBXN1 25348397 N/A physical interaction ComPPI
UBE2A ATXN10 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UBE2A FBXL6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UBE2A RETREG3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UBE2A RC3H1 25348397 N/A physical interaction ComPPI
UBE2A JPH4 25348397 N/A physical interaction ComPPI
UBE2A LLGL2 25348397 N/A physical interaction ComPPI
UBE2A H2BC5 25348397 N/A physical interaction ComPPI
UBE2A LRRC59 25348397 N/A physical interaction ComPPI
UBE2A OLA1 25348397 N/A physical interaction ComPPI
UBE2A KRT14 25348397 N/A physical interaction ComPPI
UBE2A HNRNPA1L2 25348397 N/A physical interaction ComPPI
UBE2A DSG2 25348397 N/A physical interaction ComPPI
UBE2A SRP14 25348397 N/A physical interaction ComPPI
UBE2A ELAVL1 25348397 N/A physical interaction ComPPI
UBE2A HNRNPR 25348397 N/A physical interaction ComPPI
UBE2A PNPLA6 25348397 N/A physical interaction ComPPI
UBE2A HNRNPDL 25348397 N/A physical interaction ComPPI
UBE2A HNRNPUL1 25348397 N/A physical interaction ComPPI
UBE2A RIOK1 25348397 N/A physical interaction ComPPI
UBE2A SMCHD1 25348397 N/A physical interaction ComPPI
UBE2A TSR1 25348397 N/A physical interaction ComPPI
UBE2A KIF23 25348397 N/A physical interaction ComPPI
UBE2A FAM98A 25348397 N/A physical interaction ComPPI
UBE2A RPS23 25348397 N/A physical interaction ComPPI
UBE2A EIF5AL1 25348397 N/A physical interaction ComPPI
UBE2A MRE11 25348397 N/A physical interaction ComPPI
UBE2A LGALS3BP 25348397 N/A physical interaction ComPPI
UBE2A NFKBIL1 25348397 N/A physical interaction ComPPI
UBE2A TJP2 25348397 N/A physical interaction ComPPI
UBE2A UQCRC2 25348397 N/A physical interaction ComPPI
UBE2A CCT6B 25348397 N/A physical interaction ComPPI
UBE2A RPS9 25348397 N/A physical interaction ComPPI
UBE2A NCL 25348397 N/A physical interaction ComPPI
UBE2A FLOT2 25348397 N/A physical interaction ComPPI
UBE2A ATAD3A 25348397 N/A physical interaction ComPPI
UBE2A LBR 25348397 N/A physical interaction ComPPI
UBE2A NISCH 25348397 N/A physical interaction ComPPI
UBE2A CALCOCO2 25348397 N/A physical interaction ComPPI
UBE2A FAM184B 25348397 N/A physical interaction ComPPI
UBE2A CPSF3 25348397 N/A physical interaction ComPPI
UBE2A CTNNA2 25348397 N/A physical interaction ComPPI
UBE2A NAMPT 25348397 N/A physical interaction ComPPI
UBE2A FTSJ3 25348397 N/A physical interaction ComPPI
UBE2A FARSB 25348397 N/A physical interaction ComPPI
UBE2A RPL35 25348397 N/A physical interaction ComPPI
UBE2A AAAS 25348397 N/A physical interaction ComPPI
UBE2A GCN1 25348397 N/A physical interaction ComPPI
UBE2A ANXA2P2 25348397 N/A physical interaction ComPPI
UBE2A EIF3D 25348397 N/A physical interaction ComPPI
UBE2A PKN3 25348397 N/A physical interaction ComPPI
UBE2A CLCN7 25348397 N/A physical interaction ComPPI
UBE2A TPM4 25348397 N/A physical interaction ComPPI
UBE2A PLS1 25348397 N/A physical interaction ComPPI
UBE2A H2BC11 25348397 N/A physical interaction ComPPI
UBE2A PUF60 25348397 N/A physical interaction ComPPI
UBE2A CDK5 25348397 N/A physical interaction ComPPI
UBE2A PLCD3 25348397 N/A physical interaction ComPPI
UBE2A CTNNA1 25348397 N/A physical interaction ComPPI
UBE2A THRAP3 25348397 N/A physical interaction ComPPI
UBE2A BRD9 25348397 N/A physical interaction ComPPI
UBE2A CNP 25348397 N/A physical interaction ComPPI
UBE2A HNRNPD 25348397 N/A physical interaction ComPPI
UBE2A RPS15A 25348397 N/A physical interaction ComPPI
UBE2A DNAJA1 25348397 N/A physical interaction ComPPI
UBE2A PSMD3 25348397 N/A physical interaction ComPPI
UBE2A LARS1 25348397 N/A physical interaction ComPPI
UBE2A ANXA6 25348397 N/A physical interaction ComPPI
UBE2A TOMM40 25348397 N/A physical interaction ComPPI
UBE2A TES 25348397 N/A physical interaction ComPPI
UBE2A OCM 25348397 N/A physical interaction ComPPI
UBE2A SRSF3 25348397 N/A physical interaction ComPPI
UBE2A NUP133 25348397 N/A physical interaction ComPPI
UBE2A RO60 25348397 N/A physical interaction ComPPI
UBE2A TBC1D10B 25348397 N/A physical interaction ComPPI
UBE2A GJA1 25348397 N/A physical interaction ComPPI
UBE2A BTAF1 25348397 N/A physical interaction ComPPI
UBE2A PDCD6IP 25348397 N/A physical interaction ComPPI
UBE2A CPVL 25348397 N/A physical interaction ComPPI
UBE2A CCT6A 25348397 N/A physical interaction ComPPI
UBE2A ADAR 25348397 N/A physical interaction ComPPI
UBE2A ACAT1 25348397 N/A physical interaction ComPPI
UBE2A NSA2 25348397 N/A physical interaction ComPPI
UBE2A RNF4 25348397 N/A physical interaction ComPPI
UBE2A PRKN 25348397 N/A physical interaction ComPPI
UBE2A BSG 19549727 24234451 25348397 physical association two hybrid ComPPI,IntAct
UBE2A ETNK2 19549727 24234451 25348397 physical association two hybrid ComPPI,IntAct
UBE2A CMTM2 19549727 24234451 25348397 physical association two hybrid ComPPI,IntAct
UBE2A RTF1 19410543 24234451 25348397 association pull down ComPPI,IntAct
UBE2A WDR61 19410543 24234451 25348397 association pull down ComPPI,IntAct
RPL23 UBE2A 25348397 N/A physical interaction ComPPI
PSMB1 UBE2A 25348397 N/A physical interaction ComPPI
EIF4A3 UBE2A 25348397 N/A physical interaction ComPPI
PSMF1 UBE2A 25348397 N/A physical interaction ComPPI
NIPSNAP3A UBE2A 25348397 N/A physical interaction ComPPI
NPM3 UBE2A 25348397 N/A physical interaction ComPPI
LEO1 UBE2A 19410543 24234451 25348397 association pull down ComPPI,IntAct
RNF20 UBE2A 19410543 24234451 25348397 ubiquitination reaction,association pull down,physical interaction,enzymatic study ComPPI,IntAct
MAT1A UBE2A 25348397 N/A physical interaction ComPPI
CDK1 UBE2A 11953320 14525934 N/A experimental interaction detection HPRD
UBE2A PCNA 12226657 19706603 27898060 stimulant N/A OmniPath
CDK2 UBE2A 11953320 27898060 stimulant N/A OmniPath
CDK1 UBE2A 11953320 27898060 stimulant N/A OmniPath

Visualization










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