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GENE：IL13RA1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol IL13RA1
FullNmae interleukin 13 receptor subunit alpha 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:5974
EnsembleID ENSG00000131724
Uniprot P78552

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
IL13RA1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
IL13RA1 GO:0004896,GO:0005515,GO:0005886,GO:0005898,GO:0007166,GO:0008284,GO:0009897,GO:0019221,GO:0019955,GO:0043235

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
IL13RA1 hsa:3597 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
IL13RA1 hsa:3597 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
IL13RA1 hsa:3597 path:hsa05200 Pathways in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IL4R IL13RA1 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 14657224 15099563 16243976 16413922 17404308 17485448 18243101 18250477 1825141 18451175 19833085 20184663 20406969 20510870 20856220 21097505 21115385 21469115 21840487 23124025 23180781 23390297 24030977 24091328 26192618 26755705 27216177 2965306 7512720 7521688 7543512 8910586 9535722 9834059 interaction type,physical association protein cross-linking with a bifunctional reagent,x-ray crystallography ACSN,InnateDB
IL13 IL13RA1 10485906 11867689 12223527 12401408 14610620 14657224 15099563 16243976 16413922 17404308 17485448 18250477 18451175 19833085 20184663 20406969 20510870 20856220 21097505 21115385 21469115 21840487 23124025 23180781 23331499 23390297 24030977 24091328 26192618 26755705 27216177 7512720 7521688 7543512 8910586 9013879 9535722 interaction type,stimulation,physical association saturation binding ACSN,InnateDB,SignaLink
JAK1 IL13RA1 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 14657224 15099563 16243976 16413922 17404308 17485448 18250477 1825141 18451175 19833085 20184663 20406969 20510870 20856220 21097505 21115385 21469115 21840487 23124025 23390297 24030977 24091328 26192618 26755705 27216177 2965306 7512720 7521688 7543512 9535722 9834059 interaction type N/A ACSN
JAK2 IL13RA1 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 14657224 15099563 16243976 16413922 17404308 17485448 18250477 1825141 18451175 19833085 20184663 20406969 20510870 20856220 21097505 21115385 21469115 21840487 23124025 23390297 24030977 24091328 26192618 26755705 27216177 2965306 7512720 7521688 7543512 9535722 9834059 interaction type N/A ACSN
TYK2 IL13RA1 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 14657224 15099563 16243976 16413922 17404308 17485448 18250477 1825141 18451175 19833085 20184663 20406969 20510870 20856220 21097505 21115385 21469115 21840487 23124025 23180781 23390297 24030977 24091328 26192618 26755705 27216177 2965306 7512720 7521688 7543512 9535722 9834059 interaction type,physical association unspecified method ACSN,InnateDB
IL4 IL13RA1 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20856220 21115385 21840487 23124025 23390297 24030977 24091328 26192618 27216177 2965306 7512720 7521688 7543512 9834059 interaction type N/A ACSN
IL13RA1 STAT3 10485906 11867689 12223527 12401408 14610620 14657224 15099563 16243976 16413922 17404308 17485448 18250477 18451175 19833085 20184663 20406969 20510870 20856220 21097505 21115385 21469115 21840487 23124025 23390297 24030977 24091328 26192618 26755705 27216177 7512720 7521688 7543512 9535722 interaction type N/A ACSN
IL13RA1 STAT1 10485906 11867689 12223527 12401408 14610620 14657224 15099563 16243976 16413922 17404308 17485448 18250477 18451175 19833085 20184663 20406969 20510870 20856220 21097505 21115385 21469115 21840487 23124025 23390297 24030977 24091328 26192618 26755705 27216177 7512720 7521688 7543512 9535722 interaction type N/A ACSN
IL13RA1 STAT6 10485906 10582086 11867689 12223527 12401408 14610620 14657224 15099563 16243976 16413922 17404308 17485448 18250477 18451175 19833085 20184663 20406969 20510870 20856220 21097505 21115385 21469115 21840487 23124025 23331499 23390297 24030977 24091328 26192618 26755705 27216177 7512720 7521688 7543512 9535722 interaction type,stimulation N/A ACSN,SignaLink
IL13RA1 IL18 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20856220 21115385 21840487 23124025 23390297 24030977 24091328 26192618 27216177 2965306 7512720 7521688 7543512 9834059 interaction type N/A ACSN
IL2RG IL13RA1 12207328 23180781 physical association anti tag coimmunoprecipitation InnateDB
IL13RA1 TRAF3IP1 12935900 23180781 physical association anti tag coimmunoprecipitation InnateDB
IL13RA1 JAK2 23331499 8609418 stimulation N/A SignaLink
IL13RA1 TYK2 10409622 23331499 8609418 stimulation N/A SignaLink
IL13RA1 IL4R 23331499 8910586 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
DLG4 IL13RA1 20005715 interaction type N/A PSP
DLG4 IL13RA1 18988627 20005715 7569905 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR IL13RA1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 IL13RA1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA3 IL13RA1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CTCF IL13RA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 IL13RA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS IL13RA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 IL13RA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A IL13RA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 IL13RA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 IL13RA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 IL13RA1 21097505 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS0000338542 IL13RA1 21097505 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS0000008A99 IL13RA1 23965966 25416803 27048505 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
IL13RA1 JAK3 25361965 interaction type N/A PTMCode2
JAK3 IL13RA1 25361965 interaction type N/A PTMCode2
TYK2 IL13RA1 25361965 interaction type N/A PTMCode2
IL13RA1 TYK2 25361965 interaction type N/A PTMCode2
IL4R IL13RA1 25361965 interaction type N/A PTMCode2
IL13RA1 IL4R 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TYK2 IL13RA1 10409622 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
DLG4 IL13RA1 14525934 25348397 7569905 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
RAP1GDS1 IL13RA1 25348397 N/A physical interaction ComPPI
IL13RA1 TRAF3IP1 12935900 14525934 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,in vivo,three hybrid,two hybrid ComPPI,HPRD,IntAct
IL13RA1 IL13 11278629 14525934 18243101 20223216 24234451 25348397 physical association cross-linking study,experimental interaction detection,isothermal titration calorimetry,molecular sieving,surface plasmon resonance,x-ray crystallography,physical interaction,in vivo,surface plasmon resonance array ComPPI,HPRD,IntAct
IL13RA1 IL4R 14525934 18243101 24234451 25348397 8910586 N/A experimental interaction detection,isothermal titration calorimetry,x-ray crystallography,in vitro,in vivo ComPPI,HPRD,IntAct
IL13RA1 ELAVL1 25348397 N/A physical interaction ComPPI
IL13RA1 IL2RG 25348397 N/A physical interaction ComPPI
IL13RA1 TMEM39B 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
IL13RA1 MAP4K3 25348397 N/A physical interaction ComPPI
IL13RA1 APBA3 25348397 N/A physical interaction ComPPI
IL13RA1 IL4 18243101 24234451 25348397 physical association isothermal titration calorimetry,molecular sieving,x-ray crystallography ComPPI,IntAct
IL13RA1 STAT6 10582086 27898060 stimulant N/A OmniPath
IL4 IL13RA1 10641437 12704343 18243101 27898060 stimulant N/A OmniPath
TYK2 IL13RA1 10409622 12223527 27898060 8609418 N/A N/A OmniPath
IL13RA1 TYK2 10409622 12223527 12704343 27898060 8609418 stimulant N/A OmniPath
IL13 IL13RA1 11278629 12704343 18243101 20223216 27898060 8910586 9013879 stimulant N/A OmniPath
IL4R IL13RA1 12704343 18243101 27898060 8910586 stimulant N/A OmniPath
IL13RA1 IL4R 18243101 27898060 8910586 stimulant N/A OmniPath
IL13RA1 JAK2 27898060 8609418 stimulant N/A OmniPath
IL2RG IL13RA1 12207328 27898060 N/A N/A OmniPath
IL13RA1 IL2RG 12207328 27898060 N/A N/A OmniPath
TRAF3IP1 IL13RA1 12935900 27898060 N/A N/A OmniPath
IL13RA1 IL13RA2 12704343 27898060 N/A N/A OmniPath
IL13RA2 IL13RA1 12704343 27898060 N/A N/A OmniPath

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