Gene Information gene info

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GENE：ACSL5

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ACSL5
FullNmae acyl-CoA synthetase long chain family member 5
LocusType gene with protein product
Status Approved
HGNC_id HGNC:16526
EnsembleID ENSG00000197142
Uniprot Q9ULC5

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ACSL5 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ACSL5 ferroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
ACSL5 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ACSL5 GO:0001676,GO:0001676,GO:0001676,GO:0004467,GO:0004467,GO:0004467,GO:0005515,GO:0005524,GO:0005654,GO:0005730,GO:0005739,GO:0005739,GO:0005741,GO:0005783,GO:0005783,GO:0005789,GO:0005886,GO:0010747,GO:0016020,GO:0016020,GO:0035338,GO:0035338,GO:0047676,GO:0047676

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ACSL5 hsa:51703 path:hsa00061 Fatty acid biosynthesis - Homo sapiens (human)
ACSL5 hsa:51703 path:hsa00071 Fatty acid degradation - Homo sapiens (human)
ACSL5 hsa:51703 path:hsa01100 Metabolic pathways - Homo sapiens (human)
ACSL5 hsa:51703 path:hsa01212 Fatty acid metabolism - Homo sapiens (human)
ACSL5 hsa:51703 path:hsa03320 PPAR signaling pathway - Homo sapiens (human)
ACSL5 hsa:51703 path:hsa04146 Peroxisome - Homo sapiens (human)
ACSL5 hsa:51703 path:hsa04216 Ferroptosis - Homo sapiens (human)
ACSL5 hsa:51703 path:hsa04714 Thermogenesis - Homo sapiens (human)
ACSL5 hsa:51703 path:hsa04920 Adipocytokine signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 ACSL5 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 ACSL5 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 ACSL5 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 ACSL5 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 ACSL5 20953172 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 ACSL5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ACSL5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ACSL5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ACSL5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 ACSL5 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 ACSL5 18185580 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
CREB3 ACSL5 21516116 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PEX12 ACSL5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KIF11 ACSL5 25348397 N/A physical interaction ComPPI
EBAG9 ACSL5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
COX6B1 ACSL5 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
LRRK2 ACSL5 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
SLC16A7 ACSL5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct

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