Gene Information gene info

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GENE：ORC2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ORC2
FullNmae origin recognition complex subunit 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8488
EnsembleID ENSG00000115942
Uniprot Q13416

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ORC2 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ORC2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ORC2 GO:0000122,GO:0000781,GO:0000781,GO:0000792,GO:0000808,GO:0000939,GO:0003688,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005664,GO:0005664,GO:0005664,GO:0005813,GO:0006270,GO:0016020

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ORC2 hsa:4999 path:hsa04110 Cell cycle - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CDT1 ORC2 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
MCM3 ORC2 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
MCM4 ORC2 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
MCM7 ORC2 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC2 CDC45 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC2 CDC6 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC2 MCM2 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC2 MCM5 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC2 MCM6 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC2 ORC1 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC2 ORC3 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC2 ORC4 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC2 ORC5 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC2 ORC6 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
CDK2 ORC2 14536078 15147722 15175241 15279786 15677884 16581787 17038621 17102137 17116885 17296725 17303408 17582221 17660363 17713585 18590585 18636226 19793801 26192618 7575488 interaction type N/A ACSN
CDC7 ORC2 15279786 17018296 17102137 17116885 17296725 17303408 17582221 17660363 18590585 19793801 26192618 7575488 interaction type N/A ACSN
DBF4 ORC2 15279786 17018296 17102137 17116885 17296725 17303408 17582221 17660363 18590585 19793801 26192618 7575488 interaction type N/A ACSN
RPA1 ORC2 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258 26192618 interaction type N/A ACSN
RPA2 ORC2 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258 26192618 interaction type N/A ACSN
RPA3 ORC2 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258 26192618 interaction type N/A ACSN
HUS1 ORC2 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16885023 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 26192618 8943031 9524127 interaction type N/A ACSN
RAD1 ORC2 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16885023 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 26192618 8943031 9524127 interaction type N/A ACSN
RAD17 ORC2 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16885023 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 26192618 8943031 9524127 interaction type N/A ACSN
CDK1 ORC2 14551205 15279786 17102137 17116885 17296725 17303408 17582221 17660363 18414028 18590585 19793801 26192618 7575488 interaction type N/A ACSN
ATRIP ORC2 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 26192618 8943031 9524127 association N/A ACSN
ATR ORC2 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 26192618 8943031 9524127 association N/A ACSN
CHEK1 ORC2 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 26192618 8943031 9524127 association N/A ACSN
CLSPN ORC2 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 26192618 8943031 9524127 association N/A ACSN
TIPIN ORC2 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 26192618 8943031 9524127 association N/A ACSN

Source Target Pmid Interactiontype Methods Database
ETS1 ORC2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 ORC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ORC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ORC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 ORC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ORC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ORC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ORC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00003380CC ORC2 17612493 25416803 mrna cleavage,inhibition array technology TarBase
URS0000070B1D ORC2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000017EA6A ORC2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001A405B ORC2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00005ACA7C ORC2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000078918 ORC2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000047A67D ORC2 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CDK2 ORC2 22135298 phosphorylation N/A PhosphoSite
PLK1 ORC2 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
ORC1 ORC2 11779870 11931757 14525934 15232106 16549788 17716973 22398447 24234451 25348397 26496610 association,physical association anti tag coimmunoprecipitation,coimmunoprecipitation,cosedimentation through density gradient,experimental interaction detection,protein array,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
SNW1 ORC2 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CDC5L ORC2 14525934 15232106 20467437 24234451 25348397 association anti bait coimmunoprecipitation,experimental interaction detection,protein array,physical interaction,in vitro ComPPI,HPRD,IntAct
LMNA ORC2 25348397 N/A physical interaction ComPPI
MCM5 ORC2 12614612 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
MCM6 ORC2 12614612 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
MCM2 ORC2 12614612 14525934 15232106 24234451 25348397 N/A two hybrid,experimental interaction detection,protein array,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
ORC6 ORC2 11323433 14525934 16549788 24234451 25348397 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
STN1 ORC2 25348397 N/A physical interaction ComPPI
H4C1 ORC2 25348397 N/A physical interaction ComPPI
RBM8A ORC2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FOXG1 ORC2 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
NFATC1 ORC2 25348397 N/A physical interaction ComPPI
HMGA1 ORC2 18234858 24234451 25348397 physical association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
EP300 ORC2 20808282 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ORC4 ORC2 11323433 14525934 15232106 16549788 17716973 24234451 25348397 9353276 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,cosedimentation through density gradient,experimental interaction detection,protein array,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
MCM10 ORC2 11095689 14525934 15232106 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,protein array,physical interaction,in vivo,confocal microscopy,two hybrid ComPPI,HPRD,IntAct
XRCC5 ORC2 12393188 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
RPA1 ORC2 12614612 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
CDC6 ORC2 12614612 14525934 15232106 24234451 25348397 N/A two hybrid,experimental interaction detection,protein array,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
XRCC6 ORC2 25348397 N/A physical interaction ComPPI
PARD6A ORC2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAD18 ORC2 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ANG ORC2 24234451 25348397 28777577 association anti bait coimmunoprecipitation ComPPI,IntAct
RABGAP1 ORC2 25348397 N/A physical interaction ComPPI
RPA2 ORC2 12614612 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
ORC2 MCM3 12364596 24234451 25348397 association,physical association two hybrid,coimmunoprecipitation,physical interaction,in vitro ComPPI,IntAct
ORC2 ORC3 10402192 11323433 11395502 14525934 16549788 17716973 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,cosedimentation through density gradient,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
ORC2 CDT1 14525934 15232106 24234451 25348397 N/A experimental interaction detection,protein array,physical interaction,in vitro ComPPI,HPRD,IntAct
ORC2 ORC5 11323433 14525934 15232106 16549788 17716973 24234451 25348397 26496610 9765232 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,cosedimentation through density gradient,experimental interaction detection,protein array,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
ORC2 MCM4 12364596 12614612 14525934 24234451 25348397 association two hybrid,coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
ORC2 DBF4 12441400 12614612 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
ORC2 CDC45 14525934 25348397 9660782 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
ORC2 CDK2 14525934 15232106 24234451 25348397 N/A experimental interaction detection,protein array,physical interaction,in vitro ComPPI,HPRD,IntAct
ORC2 MCM7 12614612 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
ORC2 BRCA1 25348397 N/A physical interaction ComPPI
ORC2 CCNA2 11931757 24234451 25348397 association coimmunoprecipitation,physical interaction ComPPI,IntAct
ORC2 MCM8 25348397 N/A physical interaction ComPPI
ORC2 TERF2 16799465 24234451 25348397 physical association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
ORC2 KAT7 25348397 N/A physical interaction ComPPI
ORC2 CCL2 25348397 N/A physical interaction ComPPI
ORC2 LRWD1 20850016 22935713 22939629 24234451 25348397 26344197 26496610 27898060 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
ORC2 NUCKS1 25348397 N/A physical interaction ComPPI
ORC2 FXR1 25348397 N/A physical interaction ComPPI
ORC2 H3-4 25348397 N/A physical interaction ComPPI
ORC2 SIRT2 25348397 N/A physical interaction ComPPI
ORC2 CDC42BPB 25348397 N/A physical interaction ComPPI
ORC2 PES1 25348397 N/A physical interaction ComPPI
ORC2 KIF11 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ORC2 BRINP1 25348397 N/A physical interaction ComPPI
ORC2 TEAD2 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
ORC2 FOXE1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
ORC2 FOXL1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
ORC2 FOXM1 24234451 25348397 25609649 association,physical association pull down,physical interaction,tandem affinity purification ComPPI,IntAct
ORC2 FOXQ1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
ORC2 FOXS1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
ORC2 RPGR 25348397 N/A physical interaction ComPPI
ORC2 CCNA1 11931757 24234451 25348397 association coimmunoprecipitation ComPPI,IntAct
ORC2 TERF1 16799465 24234451 25348397 physical association pull down ComPPI,IntAct
ORC2 TERF2IP 16799465 24234451 25348397 physical association pull down ComPPI,IntAct
ORC2 RNF8 18001825 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ORC2 APEX1 20808282 24234451 25348397 association affinity chromatography technology ComPPI,IntAct
ORC2 RIPPLY3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CBX5 ORC2 25348397 N/A physical interaction ComPPI
H3C1 ORC2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ILF2 ORC2 20808282 24234451 25348397 association affinity chromatography technology,physical interaction ComPPI,IntAct
SU(VAR)205 ORC2 24234451 25348397 physical association experimental interaction detection,physical interaction ComPPI,IntAct
ORC2 RHOXF2 15821142 27898060 N/A N/A OmniPath
PLK1 ORC2 21947279 23188630 27898060 N/A N/A OmniPath
CDK2 ORC2 10660590 11931757 15232106 22334659 24732362 27898060 stimulant N/A OmniPath

Visualization










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