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GENE：COPS2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol COPS2
FullNmae COP9 signalosome subunit 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:30747
EnsembleID ENSG00000166200
Uniprot P61201

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
COPS2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
COPS2 GO:0000122,GO:0000338,GO:0000338,GO:0001833,GO:0001834,GO:0003714,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005737,GO:0005737,GO:0005829,GO:0006366,GO:0006468,GO:0007165,GO:0008180,GO:0008180,GO:0008180,GO:0008180,GO:0030182,GO:0035914,GO:0045116,GO:2000434

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
COPS3 COPS2 23180781 9535219 physical association chromatography technology InnateDB
CUL1 COPS2 16036220 23180781 physical association anti tag coimmunoprecipitation InnateDB
COPS2 IRF8 10991940 23180781 physical association anti tag coimmunoprecipitation,two hybrid,pull down InnateDB
GPS1 COPS2 19444310 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF8 COPS2 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
NEDD8 COPS2 21145461 23180781 physical association anti tag coimmunoprecipitation InnateDB
COPS2 CREBBP 23180781 23441852 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
COPS2 RARA 20005715 interaction type N/A PSP
COPS2 NR2F1 20005715 interaction type N/A PSP
COPS2 THRA 20005715 interaction type N/A PSP
COPS2 RXRA 20005715 interaction type N/A PSP
COPS2 MAPK8 20005715 interaction type N/A PSP
COPS2 NR0B1 20005715 interaction type N/A PSP
COPS2 MAPK8 20005715 20005715 N/A N/A SignaLink
COPS2 NR0B1 20005715 20005715 N/A N/A SignaLink
COPS2 NR2F1 10207062 18988627 20005715 20005715 N/A N/A SignaLink
COPS2 RARA 10207062 18988627 20005715 20005715 N/A N/A SignaLink
COPS2 RXRA 18988627 20005715 20005715 7776974 N/A N/A SignaLink
COPS2 THRA 10207062 10207062 20005715 20005715 21071413 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR COPS2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 COPS2 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 COPS2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 COPS2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 COPS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA COPS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF COPS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 COPS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 COPS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 COPS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A COPS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
STAT5A COPS2 15746097 16832345 trascriptional regulation,stimulation inferred by curator TFlink
MYC COPS2 N/A trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 COPS2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000324096 COPS2 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase

Source Target Pmid Interactiontype Methods Database
IRF8 COPS2 25361965 interaction type N/A PTMCode2
COPS2 IRF8 25361965 interaction type N/A PTMCode2
COPS2 DDB1 25361965 interaction type N/A PTMCode2
DDB1 COPS2 25361965 interaction type N/A PTMCode2
COPS2 COPS6 25361965 interaction type N/A PTMCode2
COPS6 COPS2 25361965 interaction type N/A PTMCode2
COPS2 NR2F1 25361965 interaction type N/A PTMCode2
NR2F1 COPS2 25361965 interaction type N/A PTMCode2
COPS2 GPS1 25361965 interaction type N/A PTMCode2
GPS1 COPS2 25361965 interaction type N/A PTMCode2
COPS2 CUL4A 25361965 interaction type N/A PTMCode2
CUL4A COPS2 25361965 interaction type N/A PTMCode2
COPS2 NR0B1 25361965 interaction type N/A PTMCode2
NR0B1 COPS2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CUL5 COPS2 11337588 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
NPM1 COPS2 25348397 N/A physical interaction ComPPI
PSMC3 COPS2 25348397 N/A physical interaction ComPPI
FBXO17 COPS2 25348397 N/A physical interaction ComPPI
ERCC3 COPS2 25348397 N/A physical interaction ComPPI
DCUN1D1 COPS2 25348397 N/A physical interaction ComPPI
SNAI1 COPS2 19411070 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
EIF3E COPS2 25348397 N/A physical interaction ComPPI
APPBP2 COPS2 25348397 N/A physical interaction ComPPI
H4C1 COPS2 25348397 N/A physical interaction ComPPI
MAPK8 COPS2 10585392 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
JUN COPS2 24234451 25348397 25609649 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
AR COPS2 25348397 N/A physical interaction ComPPI
CREBBP COPS2 23441852 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
VDR COPS2 25348397 N/A physical interaction ComPPI
EP300 COPS2 23441852 24234451 25348397 acetylation reaction pull down,physical interaction,acetylase assay ComPPI,IntAct
PRKD1 COPS2 25348397 N/A physical interaction ComPPI
COPS5 COPS2 11285227 11337588 14525934 18850735 19615732 20399188 24234451 25043011 25348397 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,molecular sieving,x-ray crystallography,physical interaction,in vitro,tandem affinity purification,inference by socio-affinity scoring ComPPI,HPRD,IntAct
COP1 COPS2 25348397 N/A physical interaction ComPPI
IRF8 COPS2 10991940 14525934 21903422 24234451 25348397 27898060 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct,OmniPath
CDC16 COPS2 25348397 N/A physical interaction ComPPI
THRA COPS2 10207062 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
THRB COPS2 10207062 14525934 25348397 7776974 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
CUL3 COPS2 25348397 N/A physical interaction ComPPI
NCOR1 COPS2 25348397 N/A physical interaction ComPPI
IRS2 COPS2 25348397 N/A physical interaction ComPPI
PFKFB2 COPS2 25348397 N/A physical interaction ComPPI
MAP3K10 COPS2 15062575 23441852 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SIN3A COPS2 10207062 15173382 25348397 27898060 N/A physical interaction ComPPI,OmniPath
ING1 COPS2 25348397 N/A physical interaction ComPPI
PSMA6 COPS2 25348397 N/A physical interaction ComPPI
NFKBIA COPS2 17318178 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CSNK2A1 COPS2 25348397 N/A physical interaction ComPPI
GRK5 COPS2 25348397 N/A physical interaction ComPPI
TRIP11 COPS2 25348397 N/A physical interaction ComPPI
PSMC5 COPS2 25348397 N/A physical interaction ComPPI
COPS2 GFER 14525934 15304329 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,coimmunoprecipitation,cosedimentation,experimental interaction detection,physical interaction,imaging technique,in vivo ComPPI,HPRD,IntAct
COPS2 COPS3 11285227 11337588 14525934 20399188 24234451 24421388 25043011 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,molecular sieving,pull down,x-ray crystallography,physical interaction,in vitro ComPPI,HPRD,IntAct
COPS2 NR0B1 10713076 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
COPS2 COPS4 11285227 11337588 14525934 14647295 24234451 25043011 25348397 9707402 physical association experimental interaction detection,molecular sieving,x-ray crystallography,physical interaction,in vitro,in vivo,inference by socio-affinity scoring ComPPI,HPRD,IntAct
COPS2 NIF3L1 12522100 25348397 27898060 N/A two hybrid,physical interaction,in vitro,in vivo ComPPI,OmniPath
COPS2 GPS1 11114242 11285227 11337588 14525934 20399188 24234451 24421388 25348397 27029275 colocalization,physical association two hybrid,transmission electron microscopy,cosedimentation in solution,electron microscopy,experimental interaction detection,molecular sieving,x-ray crystallography,physical interaction,electron tomography,in vitro,two hybrid ComPPI,HPRD,IntAct
COPS2 COPS6 11285227 11337588 14525934 19615732 24234451 25043011 25348397 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,molecular sieving,pull down,x-ray crystallography,physical interaction,in vitro,inference by socio-affinity scoring ComPPI,HPRD,IntAct
COPS2 COPS7A 11285227 11337588 14525934 24234451 25043011 25348397 26496610 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,molecular sieving,x-ray crystallography,physical interaction,in vitro ComPPI,HPRD,IntAct
COPS2 COPS8 11285227 11337588 14525934 24234451 25043011 25348397 27173435 association,physical association experimental interaction detection,molecular sieving,pull down,x-ray crystallography,physical interaction,in vitro,tandem affinity purification,inference by socio-affinity scoring ComPPI,HPRD,IntAct
COPS2 NR2F1 10207062 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
COPS2 WRAP73 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
COPS2 KLHL13 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
COPS2 UIMC1 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
COPS2 DDB1 25348397 N/A physical interaction ComPPI
COPS2 CUL4A 25348397 N/A physical interaction ComPPI
COPS2 CUL1 25348397 N/A physical interaction ComPPI
COPS2 SIN3B 25348397 N/A physical interaction ComPPI
COPS2 CUL2 25348397 N/A physical interaction ComPPI
COPS2 ING2 25348397 N/A physical interaction ComPPI
COPS2 ABCA1 25348397 N/A physical interaction ComPPI
COPS2 TP53 11285227 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
COPS2 NEDD8 25348397 N/A physical interaction ComPPI
COPS2 ANAPC1 25348397 N/A physical interaction ComPPI
COPS2 ANAPC4 25348397 N/A physical interaction ComPPI
COPS2 PSMD5 25348397 N/A physical interaction ComPPI
COPS2 PSMC1 25348397 N/A physical interaction ComPPI
COPS2 DDB2 25348397 N/A physical interaction ComPPI
COPS2 ERCC8 25348397 N/A physical interaction ComPPI
COPS2 CUL4B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
COPS2 NAP1L1 25348397 N/A physical interaction ComPPI
COPS2 GTF2H2 25348397 N/A physical interaction ComPPI
COPS2 MED4 25348397 N/A physical interaction ComPPI
COPS2 MED23 25348397 N/A physical interaction ComPPI
COPS2 LRR1 25348397 N/A physical interaction ComPPI
COPS2 DCAF8 25348397 N/A physical interaction ComPPI
COPS2 DCAF11 25348397 N/A physical interaction ComPPI
COPS2 FBXO6 25348397 N/A physical interaction ComPPI
COPS2 COPS7B 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
COPS2 SLAIN2 25348397 N/A physical interaction ComPPI
COPS2 SEPHS1 25348397 N/A physical interaction ComPPI
COPS2 EHBP1L1 25348397 N/A physical interaction ComPPI
COPS2 GAPVD1 25348397 N/A physical interaction ComPPI
COPS2 PMPCA 25348397 N/A physical interaction ComPPI
COPS2 IRF5 25348397 N/A physical interaction ComPPI
COPS2 SENP8 25348397 N/A physical interaction ComPPI
COPS2 FBXW4 25348397 N/A physical interaction ComPPI
COPS2 EPB41L1 25348397 N/A physical interaction ComPPI
COPS2 IP6K1 25348397 N/A physical interaction ComPPI
COPS2 SARS2 25348397 N/A physical interaction ComPPI
COPS2 KLHDC3 25348397 N/A physical interaction ComPPI
COPS2 DCAF4 25348397 N/A physical interaction ComPPI
COPS2 FEM1B 25348397 N/A physical interaction ComPPI
COPS2 DCAF6 25348397 N/A physical interaction ComPPI
COPS2 FBXO7 25348397 N/A physical interaction ComPPI
COPS2 BTBD1 25348397 N/A physical interaction ComPPI
COPS2 BTBD2 25348397 N/A physical interaction ComPPI
COPS2 DCAF4L2 25348397 N/A physical interaction ComPPI
COPS2 PRAME 25348397 N/A physical interaction ComPPI
COPS2 KDM1A 25348397 N/A physical interaction ComPPI
COPS2 NUCKS1 25348397 N/A physical interaction ComPPI
COPS2 IBTK 25348397 N/A physical interaction ComPPI
COPS2 RAB5C 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
COPS2 COPS9 25348397 N/A physical interaction ComPPI
COPS2 APBB3 25348397 N/A physical interaction ComPPI
COPS2 KLHL10 25348397 N/A physical interaction ComPPI
COPS2 DET1 25348397 N/A physical interaction ComPPI
COPS2 UBE2M 25348397 N/A physical interaction ComPPI
COPS2 FBXL5 25348397 N/A physical interaction ComPPI
COPS2 DENR 25348397 N/A physical interaction ComPPI
COPS2 FBXL14 25348397 N/A physical interaction ComPPI
COPS2 SKP2 25348397 N/A physical interaction ComPPI
COPS2 TRIM25 25348397 N/A physical interaction ComPPI
COPS2 CRBN 24234451 25348397 27029275 physical association transmission electron microscopy,physical interaction ComPPI,IntAct
COPS2 DTL 25348397 N/A physical interaction ComPPI
COPS2 IKBKE 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
COPS2 CEP170P1 24234451 25348397 26496610 association anti tag coimmunoprecipitation ComPPI,IntAct
SEPTIN2 COPS2 25348397 N/A physical interaction ComPPI
H3C1 COPS2 25348397 N/A physical interaction ComPPI
CPSF1 COPS2 25348397 N/A physical interaction ComPPI
DDA1 COPS2 25348397 N/A physical interaction ComPPI
SYCE3 COPS2 25348397 N/A physical interaction ComPPI
COPS2 RXRA 14525934 7776974 N/A experimental interaction detection,two hybrid HPRD
COPS2 RARA 10207062 14525934 N/A two hybrid HPRD
COPS2 COPS2 12615944 14525934 N/A two hybrid HPRD
CREBBP COPS2 23441852 27898060 N/A N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009B00A7 COPS2 27087310 direct interaction,inhibition N/A NPInter

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