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GENE：EXOSC4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol EXOSC4
FullNmae exosome component 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:18189
EnsembleID ENSG00000178896
Uniprot Q9NPD3

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
EXOSC4 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
EXOSC4 GO:0000175,GO:0000176,GO:0000176,GO:0000177,GO:0000177,GO:0000178,GO:0000178,GO:0000460,GO:0000791,GO:0000956,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005730,GO:0005730,GO:0005730,GO:0005737,GO:0005737,GO:0005829,GO:0005829,GO:0006364,GO:0006396,GO:0006401,GO:0016075,GO:0030307,GO:0034427,GO:0034475,GO:0035925,GO:0043231,GO:0045006,GO:0051607,GO:0071028,GO:0071028,GO:0071044,GO:0071051,GO:0101019

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
EXOSC4 hsa:54512 path:hsa03018 RNA degradation - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
E2F4 EXOSC4 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 EXOSC4 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 EXOSC4 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 EXOSC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 EXOSC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A EXOSC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 EXOSC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
EXOSC5 EXOSC4 25361965 interaction type N/A PTMCode2
EXOSC4 EXOSC5 25361965 interaction type N/A PTMCode2
EXOSC4 S100A8 25361965 interaction type N/A PTMCode2
S100A8 EXOSC4 25361965 interaction type N/A PTMCode2
EXOSC4 EXOSC2 25361965 interaction type N/A PTMCode2
EXOSC2 EXOSC4 25361965 interaction type N/A PTMCode2
EXOSC4 EXOSC9 25361965 interaction type N/A PTMCode2
EXOSC9 EXOSC4 25361965 interaction type N/A PTMCode2
UPF3B EXOSC4 25361965 interaction type N/A PTMCode2
EXOSC4 UPF3B 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
NMI EXOSC4 25348397 N/A physical interaction ComPPI
EXOSC5 EXOSC4 20531386 24234451 25348397 26496610 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CBX8 EXOSC4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RPL37A EXOSC4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EXOSC1 EXOSC4 11719186 12419256 12788944 14525934 15231747 20531386 24234451 25043052 25348397 26496610 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,molecular sieving,physical interaction,in vivo,two hybrid ComPPI,HPRD,IntAct
EXOSC8 EXOSC4 11719186 14525934 20531386 24234451 25348397 26496610 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
RPL18A EXOSC4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMA3 EXOSC4 25348397 N/A physical interaction ComPPI
NTRK1 EXOSC4 25348397 N/A physical interaction ComPPI
PTPN2 EXOSC4 25348397 N/A physical interaction ComPPI
PSMA1 EXOSC4 25348397 N/A physical interaction ComPPI
PSMA6 EXOSC4 25348397 N/A physical interaction ComPPI
PSMA5 EXOSC4 25348397 N/A physical interaction ComPPI
HNRNPU EXOSC4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MPZL1 EXOSC4 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
TTC37 EXOSC4 25348397 N/A physical interaction ComPPI
EEF1A1 EXOSC4 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SDCBP EXOSC4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ABCE1 EXOSC4 25348397 N/A physical interaction ComPPI
UPF2 EXOSC4 14525934 14527413 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
EXOSC10 EXOSC4 14525934 15231747 20531386 21255825 24234451 25348397 26496610 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
H1-4 EXOSC4 25348397 N/A physical interaction ComPPI
MTREX EXOSC4 11719186 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
GABARAP EXOSC4 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
EXOSC6 EXOSC4 11719186 14525934 20531386 24234451 25348397 26496610 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
AICDA EXOSC4 21255825 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
NEK1 EXOSC4 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
MED17 EXOSC4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EED EXOSC4 25348397 N/A physical interaction ComPPI
LIG3 EXOSC4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MECP2 EXOSC4 25348397 N/A physical interaction ComPPI
PSIP1 EXOSC4 25348397 N/A physical interaction ComPPI
UPF3B EXOSC4 14525934 14527413 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
UPF1 EXOSC4 14525934 14527413 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
EXOSC4 EXOSC2 11719186 11809881 12419256 14525934 17173052 17391830 17545563 18314965 19707589 20531386 22939629 24234451 25144737 25348397 26344197 26496610 27898060 9390555 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,cosedimentation through density gradient,experimental interaction detection,physical interaction,in vitro,in vivo,tandem affinity purification,inference by socio-affinity scoring,two hybrid ComPPI,HPRD,IntAct,OmniPath
EXOSC4 GADD45GIP1 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
EXOSC4 DIS3 11719186 14525934 20531386 24234451 25348397 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
EXOSC4 EXOSC9 12788944 15231747 20531386 24234451 25348397 26496610 30021884 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,cross-linking study,physical interaction,in vivo,inference by socio-affinity scoring ComPPI,IntAct
EXOSC4 GTF2IRD1 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
EXOSC4 EXOSC7 11719186 12419256 14525934 20531386 24234451 25348397 25416956 26496610 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,mammalian protein protein interaction trap,in vivo,inference by socio-affinity scoring ComPPI,HPRD,IntAct
EXOSC4 PALS2 11719186 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
EXOSC4 LRRC8D 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
EXOSC4 SMPD4 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
EXOSC4 DXO 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
EXOSC4 EXOSC3 14525934 15231747 20531386 20531389 21255825 24234451 25348397 26496610 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
EXOSC4 HNRNPD 14525934 15231747 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
EXOSC4 AKR1A1 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
EXOSC4 EEF1A1P5 25348397 N/A physical interaction ComPPI
EXOSC4 UPF3A 25348397 N/A physical interaction ComPPI
EXOSC4 DIS3L 20531386 24234451 25348397 26496610 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
EXOSC4 DDX47 25348397 N/A physical interaction ComPPI
EXOSC4 ESR2 21182203 24234451 25348397 association cosedimentation through density gradient,physical interaction ComPPI,IntAct
EXOSC4 TSEN15 15231747 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
EXOSC4 FAHD1 15231747 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
EXOSC4 SKIV2L 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
EXOSC4 H1-10 25348397 N/A physical interaction ComPPI
EXOSC4 TOM1 25348397 N/A physical interaction ComPPI
EXOSC4 COMMD4 25348397 N/A physical interaction ComPPI
EXOSC4 MPHOSPH6 20531386 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
EXOSC4 NOP56 25348397 N/A physical interaction ComPPI
EXOSC4 PSMA4 25348397 N/A physical interaction ComPPI
EXOSC4 IFI16 25348397 N/A physical interaction ComPPI
EXOSC4 ADAR 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EXOSC4 ETFA 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EXOSC4 HNRNPA1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EXOSC4 PHF1 25348397 N/A physical interaction ComPPI
EXOSC4 RPL13 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EXOSC4 RPS3 25348397 N/A physical interaction ComPPI
EXOSC4 RPS4X 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EXOSC4 RPS10 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EXOSC4 RPS29 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EXOSC4 EIF2B4 25348397 N/A physical interaction ComPPI
EXOSC4 EIF2S2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EXOSC4 IVNS1ABP 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EXOSC4 MRPL48 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EXOSC4 GAR1 25348397 N/A physical interaction ComPPI
EXOSC4 SHQ1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EXOSC4 LRRC59 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EXOSC4 WDR18 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EXOSC4 TXNDC16 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EXOSC4 SPATA5L1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EXOSC4 MTDH 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EXOSC4 CHAMP1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EXOSC4 HBS1L 25348397 N/A physical interaction ComPPI
EXOSC4 DHPS 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
EXOSC4 LUM 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
EXOSC4 RSRC1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
EXOSC4 SLIT2 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
EXOSC4 LRRC47 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
EXOSC4 NCL 25348397 N/A physical interaction ComPPI
EXOSC4 FOXA1 25348397 N/A physical interaction ComPPI
EXOSC4 HLA-B 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
EXOSC4 ESR1 21182203 24234451 25348397 association pull down ComPPI,IntAct
EXOSC4 POLE2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EXOSC4 LNX1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
C1D EXOSC4 25348397 N/A physical interaction ComPPI
KPNA6 EXOSC4 25348397 N/A physical interaction ComPPI
UTP3 EXOSC4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HMGB3 EXOSC4 25348397 N/A physical interaction ComPPI
EXOSC4 EXOSC4 12419256 14525934 N/A two hybrid HPRD
EXOSC4 TET3 24234451 30021884 physical association cross-linking study IntAct

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