GENE:KLF3
GeneInfo:
GeneAttribute | GeneDescription |
---|---|
GeneSymbol | KLF3 |
FullNmae | KLF transcription factor 3 |
LocusType | gene with protein product |
Status | Approved |
HGNC_id | HGNC:16516 |
EnsembleID | ENSG00000109787 |
Uniprot | P57682 |
Protein Structure:
Gene Description in Publicaton:
GeneSymbol | CellDeathType | PMID | Description | GeneType |
---|---|---|---|---|
KLF3 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
GeneSymbol | Go id |
---|---|
KLF3 | GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0000981,GO:0003700,GO:0005515,GO:0005654,GO:0006357,GO:0030097,GO:0046872,GO:1901653,GO:1990837 |
KEGG Annotation:
GeneSymbol | GeneID | Pathway | Pathway Name |
---|---|---|---|
KLF3 | hsa:51274 | path:hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
AR | KLF3 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
E2F4 | KLF3 | 17531812 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
GATA1 | KLF3 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
GATA2 | KLF3 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
GATA3 | KLF3 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
FOXA1 | KLF3 | 18971253 21878914 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
TFAP2C | KLF3 | 20629094 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
FOXP3 | KLF3 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
PRDM14 | KLF3 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
SMARCA4 | KLF3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
CEBPA | KLF3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
CTCF | KLF3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
E2F1 | KLF3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
EGR1 | KLF3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
FOS | KLF3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
HNF4A | KLF3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
MITF | KLF3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
TAL1 | KLF3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
TP53 | KLF3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
URS0000237AF9 | KLF3 | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
URS0000122ED0 | KLF3 | 19088304 25416803 | mrna cleavage,inhibition | array technology | TarBase |
URS00001CC864 | KLF3 | 23918807 25416803 | mrna cleavage,inhibition | western blot,miRNA interference luciferase reporter assay | TarBase |
URS00002075FA | KLF3 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000042E1F | KLF3 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00000DDD35 | KLF3 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000039E1E1 | KLF3 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00000600E6 | KLF3 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000070CD2 | KLF3 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000346991 | KLF3 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000027080C | KLF3 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000041E949 | KLF3 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000508C13 | KLF3 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00000254A6 | KLF3 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00002B3783 | KLF3 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000298BA3 | KLF3 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00002198F3 | KLF3 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000012930C | KLF3 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00001F9A0F | KLF3 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000024B619 | KLF3 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000122F23 | KLF3 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000017DBB8 | KLF3 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
HIPK2 | KLF3 | 22135298 | phosphorylation | N/A | PhosphoSite |
KLF3 | CTBP2 | 25361965 | interaction type | N/A | PTMCode2 |
CTBP2 | KLF3 | 25361965 | interaction type | N/A | PTMCode2 |
KLF3 | FHL3 | 25361965 | interaction type | N/A | PTMCode2 |
FHL3 | KLF3 | 25361965 | interaction type | N/A | PTMCode2 |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
FHL3 | KLF3 | 24234451 25348397 25416956 27107012 | physical association | physical interaction,mammalian protein protein interaction trap,two hybrid array,two hybrid prey pooling approach,validated two hybrid,barcode fusion genetics two hybrid | ComPPI,IntAct |
EHMT2 | KLF3 | 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
CTBP1 | KLF3 | 25348397 | N/A | physical interaction | ComPPI |
CTBP2 | KLF3 | 14525934 25348397 9724649 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
TRAF2 | KLF3 | 24234451 25348397 25416956 | physical association | physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
TRIM25 | KLF3 | 25348397 | N/A | physical interaction | ComPPI |
DVL3 | KLF3 | 24234451 25348397 25416956 | physical association | physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
KDM1A | KLF3 | 23455924 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
KLF3 | SUV39H2 | 23455924 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
KLF3 | LHX8 | 24234451 25348397 25416956 | physical association | physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
KLF3 | LHX6 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
HIPK2 | KLF3 | 25659434 27898060 | N/A | N/A | OmniPath |