GENE：ADCY8
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | ADCY8 |
| FullNmae | adenylate cyclase 8 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:239 |
| EnsembleID | ENSG00000155897 |
| Uniprot | P40145 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| ADCY8 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| ADCY8 | GO:0003779,GO:0004016,GO:0004016,GO:0005516,GO:0005524,GO:0005886,GO:0005886,GO:0005901,GO:0005905,GO:0006171,GO:0007165,GO:0007189,GO:0007204,GO:0007611,GO:0007613,GO:0007616,GO:0007626,GO:0008294,GO:0010255,GO:0014069,GO:0015629,GO:0016020,GO:0016323,GO:0016324,GO:0030424,GO:0030425,GO:0030665,GO:0031915,GO:0032793,GO:0032809,GO:0034199,GO:0035556,GO:0035774,GO:0038003,GO:0042593,GO:0042734,GO:0042803,GO:0044853,GO:0045121,GO:0046872,GO:0046982,GO:0046983,GO:0048786,GO:0050796,GO:0051259,GO:0051260,GO:0051480,GO:0051721,GO:0060076,GO:0071277,GO:0071315,GO:0071333,GO:0071377,GO:0080135,GO:0098685,GO:0098686,GO:0098978,GO:0150076,GO:1900273,GO:1900454,GO:1904322 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| ADCY8 | hsa:114 | path:hsa00230 | Purine metabolism - Homo sapiens (human) |
| ADCY8 | hsa:114 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| ADCY8 | hsa:114 | path:hsa01522 | Endocrine resistance - Homo sapiens (human) |
| ADCY8 | hsa:114 | path:hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| ADCY8 | hsa:114 | path:hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| ADCY8 | hsa:114 | path:hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
| ADCY8 | hsa:114 | path:hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
| ADCY8 | hsa:114 | path:hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| ADCY8 | hsa:114 | path:hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| ADCY8 | hsa:114 | path:hsa04114 | Oocyte meiosis - Homo sapiens (human) |
| ADCY8 | hsa:114 | path:hsa04211 | Longevity regulating pathway - Homo sapiens (human) |
| ADCY8 | hsa:114 | path:hsa04213 | Longevity regulating pathway - multiple species - Homo sapiens (human) |
| ADCY8 | hsa:114 | path:hsa04261 | Adrenergic signaling in cardiomyocytes - Homo sapiens (human) |
| ADCY8 | hsa:114 | path:hsa04270 | Vascular smooth muscle contraction - Homo sapiens (human) |
| ADCY8 | hsa:114 | path:hsa04371 | Apelin signaling pathway - Homo sapiens (human) |
| ADCY8 | hsa:114 | path:hsa04540 | Gap junction - Homo sapiens (human) |
| ADCY8 | hsa:114 | path:hsa04611 | Platelet activation - Homo sapiens (human) |
| ADCY8 | hsa:114 | path:hsa04713 | Circadian entrainment - Homo sapiens (human) |
| ADCY8 | hsa:114 | path:hsa04714 | Thermogenesis - Homo sapiens (human) |
| ADCY8 | hsa:114 | path:hsa04720 | Long-term potentiation - Homo sapiens (human) |
| ADCY8 | hsa:114 | path:hsa04723 | Retrograde endocannabinoid signaling - Homo sapiens (human) |
| ADCY8 | hsa:114 | path:hsa04724 | Glutamatergic synapse - Homo sapiens (human) |
| ADCY8 | hsa:114 | path:hsa04725 | Cholinergic synapse - Homo sapiens (human) |
| ADCY8 | hsa:114 | path:hsa04727 | GABAergic synapse - Homo sapiens (human) |
| ADCY8 | hsa:114 | path:hsa04742 | Taste transduction - Homo sapiens (human) |
| ADCY8 | hsa:114 | path:hsa04750 | Inflammatory mediator regulation of TRP channels - Homo sapiens (human) |
| ADCY8 | hsa:114 | path:hsa04911 | Insulin secretion - Homo sapiens (human) |
| ADCY8 | hsa:114 | path:hsa04912 | GnRH signaling pathway - Homo sapiens (human) |
| ADCY8 | hsa:114 | path:hsa04913 | Ovarian steroidogenesis - Homo sapiens (human) |
| ADCY8 | hsa:114 | path:hsa04914 | Progesterone-mediated oocyte maturation - Homo sapiens (human) |
| ADCY8 | hsa:114 | path:hsa04915 | Estrogen signaling pathway - Homo sapiens (human) |
| ADCY8 | hsa:114 | path:hsa04916 | Melanogenesis - Homo sapiens (human) |
| ADCY8 | hsa:114 | path:hsa04918 | Thyroid hormone synthesis - Homo sapiens (human) |
| ADCY8 | hsa:114 | path:hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| ADCY8 | hsa:114 | path:hsa04923 | Regulation of lipolysis in adipocytes - Homo sapiens (human) |
| ADCY8 | hsa:114 | path:hsa04925 | Aldosterone synthesis and secretion - Homo sapiens (human) |
| ADCY8 | hsa:114 | path:hsa04926 | Relaxin signaling pathway - Homo sapiens (human) |
| ADCY8 | hsa:114 | path:hsa04927 | Cortisol synthesis and secretion - Homo sapiens (human) |
| ADCY8 | hsa:114 | path:hsa04928 | Parathyroid hormone synthesis, secretion and action - Homo sapiens (human) |
| ADCY8 | hsa:114 | path:hsa04934 | Cushing syndrome - Homo sapiens (human) |
| ADCY8 | hsa:114 | path:hsa04935 | Growth hormone synthesis, secretion and action - Homo sapiens (human) |
| ADCY8 | hsa:114 | path:hsa04970 | Salivary secretion - Homo sapiens (human) |
| ADCY8 | hsa:114 | path:hsa04971 | Gastric acid secretion - Homo sapiens (human) |
| ADCY8 | hsa:114 | path:hsa04972 | Pancreatic secretion - Homo sapiens (human) |
| ADCY8 | hsa:114 | path:hsa04976 | Bile secretion - Homo sapiens (human) |
| ADCY8 | hsa:114 | path:hsa05032 | Morphine addiction - Homo sapiens (human) |
| ADCY8 | hsa:114 | path:hsa05163 | Human cytomegalovirus infection - Homo sapiens (human) |
| ADCY8 | hsa:114 | path:hsa05166 | Human T-cell leukemia virus 1 infection - Homo sapiens (human) |
| ADCY8 | hsa:114 | path:hsa05200 | Pathways in cancer - Homo sapiens (human) |
| ADCY8 | hsa:114 | path:hsa05207 | Chemical carcinogenesis - receptor activation - Homo sapiens (human) |
| ADCY8 | hsa:114 | path:hsa05414 | Dilated cardiomyopathy - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | ADCY8 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| YBX1 | ADCY8 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | ADCY8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | ADCY8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | ADCY8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | ADCY8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | ADCY8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | ADCY8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | ADCY8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | ADCY8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | ADCY8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | ADCY8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CALM1 | ADCY8 | 25348397 | N/A | physical interaction | ComPPI |
| CFTR | ADCY8 | 17110338 24234451 25348397 | association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| ADCY8 | PPP2CA | 14525934 16258073 27898060 | N/A | experimental interaction detection,two hybrid | HPRD,OmniPath |
| ADCY8 | CALM2 | 10075700 14525934 16258073 | N/A | experimental interaction detection | HPRD |