GENE:SPSB1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | SPSB1 |
| FullNmae | splA/ryanodine receptor domain and SOCS box containing 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:30628 |
| EnsembleID | ENSG00000171621 |
| Uniprot | Q96BD6 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| SPSB1 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| SPSB1 | GO:0005515,GO:0005829,GO:0005829,GO:0006511,GO:0016567,GO:0016567,GO:0019005,GO:0043161,GO:1990756 |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ELOC | SPSB1 | 15601820 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| ELOB | SPSB1 | 15601820 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| RNF7 | SPSB1 | 15601820 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| CUL5 | SPSB1 | 15601820 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| SPSB1 | ELAVL1 | 19322201 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | SPSB1 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | SPSB1 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | SPSB1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | SPSB1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| TFAP2C | SPSB1 | 20629094 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| CEBPA | SPSB1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | SPSB1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | SPSB1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | SPSB1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | SPSB1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | SPSB1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | SPSB1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | SPSB1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | SPSB1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000237AF9 | SPSB1 | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS000048BA36 | SPSB1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000001A7A | SPSB1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000214763 | SPSB1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000047A8F | SPSB1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000192A75 | SPSB1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000527B00 | SPSB1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000020579D | SPSB1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004719AB | SPSB1 | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000427B68 | SPSB1 | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000202460 | SPSB1 | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C4DB5 | SPSB1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS000019907A | SPSB1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS0000137EDE | SPSB1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS000075A9CF | SPSB1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00005F9738 | SPSB1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS0000122F23 | SPSB1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00002CBC6D | SPSB1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS0000021D08 | SPSB1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CUL5 | SPSB1 | 15601820 24234451 25348397 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| SNAI1 | SPSB1 | 24234451 25203322 25348397 | physical association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| HSP90AB1 | SPSB1 | 22939624 24234451 25348397 | physical association | luminescence based mammalian interactome mapping | ComPPI,IntAct |
| RNF7 | SPSB1 | 15601820 24234451 25348397 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| TGFBR2 | SPSB1 | 25348397 | N/A | physical interaction | ComPPI |
| HSP90AA1 | SPSB1 | 25348397 | N/A | physical interaction | ComPPI |
| PRMT1 | SPSB1 | 23455924 24234451 25348397 | physical association | anti tag coimmunoprecipitation,two hybrid,physical interaction | ComPPI,IntAct |
| HNRNPL | SPSB1 | 25348397 | N/A | physical interaction | ComPPI |
| TP73 | SPSB1 | 25348397 | N/A | physical interaction | ComPPI |
| PAWR | SPSB1 | 20561531 24234451 25348397 | N/A | isothermal titration calorimetry,x-ray crystallography,physical interaction | ComPPI,IntAct |
| ATM | SPSB1 | 25348397 | N/A | physical interaction | ComPPI |
| SUV39H1 | SPSB1 | 23455924 24234451 25348397 | physical association | anti tag coimmunoprecipitation,two hybrid,physical interaction | ComPPI,IntAct |
| MET | SPSB1 | 14525934 15713673 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| RASA1 | SPSB1 | 14525934 15713673 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| NOS2 | SPSB1 | 25348397 | N/A | physical interaction | ComPPI |
| ELOB | SPSB1 | 15601820 24234451 25348397 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| ELOC | SPSB1 | 15601820 24234451 25348397 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| ELAVL1 | SPSB1 | 25348397 | N/A | physical interaction | ComPPI |
| KDM1A | SPSB1 | 23455924 24234451 25348397 | physical association | anti tag coimmunoprecipitation,two hybrid,physical interaction | ComPPI,IntAct |
| DDX4 | SPSB1 | 25348397 | N/A | physical interaction | ComPPI |
| SPSB1 | TP53 | 25348397 | N/A | physical interaction | ComPPI |
| SPSB1 | HSP90AA2P | 25348397 | N/A | physical interaction | ComPPI |
| SPSB1 | PRMT6 | 23455924 24234451 25348397 | physical association | anti tag coimmunoprecipitation,two hybrid,physical interaction | ComPPI,IntAct |
| SPSB1 | VWA5A | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| ADPRH | SPSB1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| SPSB1 | VAS | 20561531 24234451 | N/A | isothermal titration calorimetry,x-ray crystallography | IntAct |
| MET | SPSB1 | 15713673 27898060 | N/A | N/A | OmniPath |
