GENE：GM2A
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | GM2A |
| FullNmae | ganglioside GM2 activator |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:4367 |
| EnsembleID | ENSG00000196743 |
| Uniprot | P17900 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| GM2A | pyroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| GM2A | lysosomal_cd | 36341760 | 220 lysosome-dependent cell death genes. | retulator signature |
| GM2A | lysosomal_cd | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| GM2A | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| GM2A | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| GM2A | GO:0005319,GO:0005576,GO:0005829,GO:0006687,GO:0006689,GO:0006869,GO:0007611,GO:0009313,GO:0009898,GO:0016004,GO:0016323,GO:0016324,GO:0019915,GO:0030290,GO:0032428,GO:0035578,GO:0043202,GO:0043231,GO:0050885,GO:0051651,GO:0070062 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| GM2A | hsa:2760 | path:hsa00600 | Sphingolipid metabolism - Homo sapiens (human) |
| GM2A | hsa:2760 | path:hsa04142 | Lysosome - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | GM2A | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | GM2A | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | GM2A | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | GM2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | GM2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | GM2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | GM2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | GM2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | GM2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | GM2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | GM2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | GM2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | GM2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | GM2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SP1 | GM2A | 10987359 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| DAND5 | GM2A | 10987359 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| JUN | GM2A | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TFAP2A | GM2A | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00005E6F45 | GM2A | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002FF522 | GM2A | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001270D3 | GM2A | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000CBE63 | GM2A | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000045B99E | GM2A | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000427B68 | GM2A | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000AD002 | GM2A | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000039A052 | GM2A | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001C85C7 | GM2A | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C85B2 | GM2A | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075C4B1 | GM2A | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000007F792 | GM2A | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000355E82 | GM2A | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001A7F58 | GM2A | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000B989F | GM2A | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002FC5B0 | GM2A | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000016914 | GM2A | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000435A77 | GM2A | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000041E780 | GM2A | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000029EBD | GM2A | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS000003575B | GM2A | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS000021202F | GM2A | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS000075CC78 | GM2A | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS000075D814 | GM2A | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00001012BC | GM2A | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GMCL1 | GM2A | 25348397 | N/A | physical interaction | ComPPI |
| TBC1D22B | GM2A | 25348397 | N/A | physical interaction | ComPPI |
| PDE4DIP | GM2A | 25348397 | N/A | physical interaction | ComPPI |
| FTH1 | GM2A | 25348397 | N/A | physical interaction | ComPPI |
| GABARAPL2 | GM2A | 20562859 24234451 25348397 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| PLD2 | GM2A | 11672434 14525934 25348397 27898060 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
| CDH1 | GM2A | 25348397 | N/A | physical interaction | ComPPI |
| SF3A1 | GM2A | 25348397 | N/A | physical interaction | ComPPI |
| GM2A | ELAVL1 | 25348397 | N/A | physical interaction | ComPPI |
| GM2A | KIR3DS1 | 25348397 | N/A | physical interaction | ComPPI |
| GM2A | GMCL2 | 25348397 | N/A | physical interaction | ComPPI |
| GM2A | HNRNPA1 | 25348397 | N/A | physical interaction | ComPPI |
| GM2A | SINHCAF | 25348397 | N/A | physical interaction | ComPPI |
| GM2A | AIRE | 25348397 | N/A | physical interaction | ComPPI |
| GM2A | VNN2 | 25348397 | N/A | physical interaction | ComPPI |
| GM2A | ACTA2 | 25348397 | N/A | physical interaction | ComPPI |
| DDX19B | GM2A | 25348397 | N/A | physical interaction | ComPPI |
| ECH1 | GM2A | 24234451 25348397 29426014 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |