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GENE：AK2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol AK2
FullNmae adenylate kinase 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:362
EnsembleID ENSG00000004455
Uniprot P54819

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
AK2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
AK2 GO:0004017,GO:0004017,GO:0005515,GO:0005524,GO:0005737,GO:0005739,GO:0005758,GO:0006172,GO:0015949,GO:0016310,GO:0046033,GO:0046034,GO:0046940,GO:0070062,GO:0097226

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
AK2 hsa:204 path:hsa00230 Purine metabolism - Homo sapiens (human)
AK2 hsa:204 path:hsa00730 Thiamine metabolism - Homo sapiens (human)
AK2 hsa:204 path:hsa01100 Metabolic pathways - Homo sapiens (human)
AK2 hsa:204 path:hsa01232 Nucleotide metabolism - Homo sapiens (human)
AK2 hsa:204 path:hsa01240 Biosynthesis of cofactors - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR AK2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 AK2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 AK2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 AK2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
HIF1A AK2 18971253 19828020 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
SMARCA4 AK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA AK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF AK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 AK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 AK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 AK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 AK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS AK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A AK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF AK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 AK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000122ED0 AK2 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS0000065D58 AK2 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00003CF1AD AK2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000367985 AK2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00005F1B8C AK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000023F008 AK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001C770D AK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000BE495 AK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001F0C23 AK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002578DA AK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000061E50F AK2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000031602A AK2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003E226A AK2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000D0BB4 AK2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000044FD7 AK2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000029D9F1 AK2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000EED18 AK2 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
AK2 NME1 25361965 interaction type N/A PTMCode2
NME1 AK2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
EIF1B AK2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PAK2 AK2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
BAG3 AK2 25348397 N/A physical interaction ComPPI
TRAF6 AK2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TUFM AK2 25348397 N/A physical interaction ComPPI
RACK1 AK2 25348397 N/A physical interaction ComPPI
JUN AK2 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
U2AF2 AK2 25348397 N/A physical interaction ComPPI
CUL3 AK2 25348397 N/A physical interaction ComPPI
DUT AK2 25348397 N/A physical interaction ComPPI
DLD AK2 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
NTRK1 AK2 25348397 N/A physical interaction ComPPI
MAPT AK2 25348397 N/A physical interaction ComPPI
FSCN1 AK2 25348397 N/A physical interaction ComPPI
PDHA1 AK2 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TRAP1 AK2 25348397 N/A physical interaction ComPPI
ABCE1 AK2 25348397 N/A physical interaction ComPPI
HUWE1 AK2 25348397 N/A physical interaction ComPPI
ACAA2 AK2 25348397 N/A physical interaction ComPPI
HDAC6 AK2 25348397 N/A physical interaction ComPPI
RAVER1 AK2 25348397 N/A physical interaction ComPPI
VCAM1 AK2 22623428 24234451 25348397 association cross-linking study ComPPI,IntAct
BCOR AK2 25348397 N/A physical interaction ComPPI
SAFB AK2 25348397 N/A physical interaction ComPPI
SOD1 AK2 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
IKBKE AK2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
DSP AK2 25348397 N/A physical interaction ComPPI
SHBG AK2 14525934 15862967 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
AK2 MEPCE 25348397 N/A physical interaction ComPPI
AK2 SLC25A10 25348397 N/A physical interaction ComPPI
AK2 TELO2 25348397 N/A physical interaction ComPPI
AK2 IDH1 25348397 N/A physical interaction ComPPI
AK2 ABCC6 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
AK2 ABCC5 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
AK2 AFG3L2 25348397 N/A physical interaction ComPPI
AK2 CRIP1 25348397 N/A physical interaction ComPPI
AK2 MRPS7 25348397 N/A physical interaction ComPPI
AK2 NME2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
AK2 SIGMAR1 25348397 N/A physical interaction ComPPI
AK2 TKT 25348397 N/A physical interaction ComPPI
AK2 CEP290 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
AK2 SBF2 25348397 N/A physical interaction ComPPI
AK2 AIFM1 24234451 25348397 29568061 association pull down,physical interaction,proximity-dependent biotin identification ComPPI,IntAct
AK2 MCC 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
AK2 GH1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
AK2 EPB41 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
AK2 ACTR6 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
AK2 OTUB1 24234451 25348397 26752685 association anti tag coimmunoprecipitation ComPPI,IntAct
AK2 COX14 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
AK2 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
AK2 SFXN1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PLGRKT AK2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MRPL12 AK2 25348397 N/A physical interaction ComPPI
AK2 USP26 24234451 30021884 physical association cross-linking study IntAct
AK2 MAP9 24234451 30021884 physical association cross-linking study IntAct
AK2 ADCY5 24234451 30021884 physical association cross-linking study IntAct

Visualization










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