Gene Information gene info

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GENE：ITSN1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ITSN1
FullNmae intersectin 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6183
EnsembleID ENSG00000205726
Uniprot Q15811

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ITSN1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ITSN1 GO:0005085,GO:0005085,GO:0005509,GO:0005515,GO:0005635,GO:0005737,GO:0005829,GO:0005886,GO:0005886,GO:0005905,GO:0006887,GO:0008104,GO:0015031,GO:0016197,GO:0030027,GO:0035556,GO:0042734,GO:0043005,GO:0051056,GO:0055037,GO:0060090,GO:0060090,GO:0070064,GO:0097708,GO:0150007

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ITSN1 HRAS 12970366 23180781 physical association anti tag coimmunoprecipitation,fluorescent resonance energy transfer InnateDB
ITSN1 SOS1 12970366 23180781 physical association gst pull down InnateDB
EPHB2 ITSN1 12389031 23331499 stimulation N/A SignaLink
ITSN1 CDC42 11584276 12006984 15824104 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR ITSN1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 ITSN1 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
GATA2 ITSN1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
PRDM14 ITSN1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 ITSN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ITSN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ITSN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 ITSN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ITSN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ITSN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 ITSN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ITSN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ITSN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF ITSN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 ITSN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 ITSN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001C3AC1 ITSN1 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
LMO4 ITSN1 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
PPL ITSN1 25348397 N/A physical interaction ComPPI
GCC1 ITSN1 25348397 N/A physical interaction ComPPI
RNF40 ITSN1 25348397 N/A physical interaction ComPPI
DES ITSN1 25348397 N/A physical interaction ComPPI
WASL ITSN1 11584276 14525934 18539136 24234451 25348397 colocalization,physical association coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,imaging technique,in vitro,in vivo ComPPI,HPRD,IntAct
CDC42 ITSN1 11584276 12006984 14525934 15824104 25348397 N/A experimental interaction detection,x-ray crystallography,physical interaction,in vitro ComPPI,HPRD
SPRY2 ITSN1 22158968 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SH3KBP1 ITSN1 25348397 N/A physical interaction ComPPI
PACSIN3 ITSN1 25348397 N/A physical interaction ComPPI
WAS ITSN1 25348397 N/A physical interaction ComPPI
TK1 ITSN1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SF3B4 ITSN1 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SCAMP1 ITSN1 10777571 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
DAB2 ITSN1 25348397 N/A physical interaction ComPPI
CBL ITSN1 16914641 17875942 18539136 18654987 21712076 24234451 25348397 27898060 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,far western blotting,pull down,physical interaction,fluorescence microscopy ComPPI,IntAct,OmniPath
HRAS ITSN1 12970366 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CBLB ITSN1 25348397 N/A physical interaction ComPPI
GP6 ITSN1 25348397 N/A phage display,physical interaction ComPPI
PIK3R1 ITSN1 25348397 N/A physical interaction ComPPI
SOS1 ITSN1 10716926 14525934 15824104 20936779 24234451 25348397 association,physical association coimmunoprecipitation,experimental interaction detection,physical interaction,two hybrid pooling approach,imaging technique,in vitro,in vivo ComPPI,HPRD,IntAct
EPHB2 ITSN1 12389031 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
DSTN ITSN1 25348397 N/A physical interaction ComPPI
KHDRBS1 ITSN1 25348397 N/A physical interaction ComPPI
UNC119 ITSN1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
INPPL1 ITSN1 18692052 25348397 27898060 N/A two hybrid ComPPI,OmniPath
PIK3AP1 ITSN1 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
WBP11 ITSN1 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PICALM ITSN1 25348397 N/A physical interaction ComPPI
EPN2 ITSN1 25348397 N/A physical interaction ComPPI
DLGAP1 ITSN1 25348397 N/A physical interaction ComPPI
DNM1 ITSN1 10373452 14525934 15834155 18539136 24234451 25348397 N/A experimental interaction detection,pull down,surface plasmon resonance,physical interaction,in vitro,in vivo,surface plasmon resonance array ComPPI,HPRD,IntAct
CCNO ITSN1 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PLK1 ITSN1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TTC37 ITSN1 25348397 N/A physical interaction ComPPI
EEF1A1 ITSN1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
SNAP25 ITSN1 10373452 14525934 16874303 24234451 25348397 colocalization two hybrid,experimental interaction detection,physical interaction,imaging technique,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
SNAP23 ITSN1 10373452 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAPK6 ITSN1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CYTH1 ITSN1 25348397 N/A physical interaction ComPPI
PDE4D ITSN1 25348397 N/A physical interaction ComPPI
RAD18 ITSN1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAPK8IP2 ITSN1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GOLGA5 ITSN1 25348397 N/A physical interaction ComPPI
RABEP1 ITSN1 25348397 N/A physical interaction ComPPI
RAB5A ITSN1 25348397 N/A physical interaction ComPPI
RUNDC3A ITSN1 25348397 N/A physical interaction ComPPI
REPS1 ITSN1 25348397 N/A physical interaction ComPPI
PPFIA2 ITSN1 25348397 N/A physical interaction ComPPI
CLTC ITSN1 25348397 N/A physical interaction ComPPI
EPS15 ITSN1 10064583 10922467 14525934 22558309 24234451 25348397 26344197 27898060 physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,IntAct,OmniPath
ARF6 ITSN1 25348397 N/A physical interaction ComPPI
AP2B1 ITSN1 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMNDC1 ITSN1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ITSN1 SYNJ1 10373452 14525934 18539136 24234451 25348397 physical association experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
ITSN1 ARHGAP31 11744688 14525934 18539136 24234451 25348397 physical association experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
ITSN1 STON2 11381094 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
ITSN1 KIF5A 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
ITSN1 SMARCC2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
ITSN1 SNX5 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
ITSN1 MRPL20 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
ITSN1 TSG101 25348397 N/A physical interaction ComPPI
ITSN1 DISC1 12812986 14525934 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
ITSN1 EEF1A1P5 25348397 N/A physical interaction ComPPI
ITSN1 DNM2 14525934 15834155 16696976 21900206 24234451 25348397 physical association two hybrid,experimental interaction detection,surface plasmon resonance,physical interaction,surface plasmon resonance array ComPPI,HPRD,IntAct
ITSN1 CSNK2B 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ITSN1 RPS6KA5 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ITSN1 UBE2K 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ITSN1 MAP3K20 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ITSN1 ASAP2 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ITSN1 PFDN5 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ITSN1 FNBP4 25348397 N/A physical interaction ComPPI
ITSN1 ZFPM2 25348397 N/A physical interaction ComPPI
ITSN1 AGFG1 25348397 N/A physical interaction ComPPI
ITSN1 RAB11FIP2 25348397 N/A physical interaction ComPPI
ITSN1 AGFG2 25348397 N/A physical interaction ComPPI
ITSN1 CLIP2 25348397 N/A physical interaction ComPPI
ITSN1 EPS15L1 25348397 N/A physical interaction ComPPI
ITSN1 SPDL1 25348397 N/A physical interaction ComPPI
ITSN1 KIF16B 25348397 N/A physical interaction ComPPI
ITSN1 ARFIP2 25348397 N/A physical interaction ComPPI
ITSN1 FNBP1 25348397 N/A physical interaction ComPPI
ITSN1 HIP1 25348397 N/A physical interaction ComPPI
ITSN1 MTUS2 25348397 N/A physical interaction ComPPI
ITSN1 CEP85L 25348397 N/A physical interaction ComPPI
ITSN1 PDCD6IP 25348397 N/A physical interaction ComPPI
ITSN1 PREX1 25348397 N/A physical interaction ComPPI
ITSN1 RAI14 25348397 N/A physical interaction ComPPI
ITSN1 SCOC 25348397 N/A physical interaction ComPPI
ITSN1 TRIM8 25348397 N/A physical interaction ComPPI
ITSN1 PIK3C2B 25348397 N/A physical interaction ComPPI
ITSN1 GAREM2 25348397 N/A physical interaction ComPPI
ITSN1 SYNJ2 25348397 N/A physical interaction ComPPI
ITSN1 FCHSD2 25348397 N/A physical interaction ComPPI
ITSN1 ITSN2 25348397 N/A physical interaction ComPPI
ITSN1 AMPH 25348397 N/A physical interaction ComPPI
ITSN1 SGIP1 25348397 N/A physical interaction ComPPI
ITSN1 PAK3 25348397 N/A physical interaction ComPPI
ITSN1 SKIV2L 25348397 N/A physical interaction ComPPI
ITSN1 SETD3 25348397 N/A physical interaction ComPPI
ITSN1 IGBP1 25348397 N/A physical interaction ComPPI
ITSN1 RNASEH2A 25348397 N/A physical interaction ComPPI
ITSN1 PHGDH 24234451 25036637 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ITSN1 NECAP2 25348397 N/A physical interaction ComPPI
ITSN1 DTX3 25348397 N/A physical interaction ComPPI
ITSN1 AP2M1 25348397 N/A physical interaction ComPPI
ITSN1 TFG 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ITSN1 ITCH 25348397 N/A physical interaction ComPPI
ITSN1 AP2S1 25348397 N/A physical interaction ComPPI
ITSN1 NCKIPSD 25348397 N/A physical interaction ComPPI
ITSN1 LSR 25348397 N/A physical interaction ComPPI
ITSN1 GATD1 25348397 N/A physical interaction ComPPI
ITSN1 ALOX5 25348397 N/A physical interaction ComPPI
ITSN1 TRIM25 25348397 N/A physical interaction ComPPI
ITSN1 DBH 16874303 24234451 25348397 colocalization imaging technique ComPPI,IntAct
ITSN1 TGOLN2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ITSN1 EZR 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
SH3GL2 ITSN1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PTPN11 ITSN1 24216759 27898060 N/A N/A OmniPath
HRAS ITSN1 12970366 27898060 N/A N/A OmniPath
SOS1 ITSN1 10716926 12970366 15824104 18539136 20936779 27898060 N/A N/A OmniPath
ITSN1 SOS1 10716926 12970366 15824104 18539136 20936779 27898060 N/A N/A OmniPath
ITSN1 CDC42 11584276 12006984 15824104 27898060 stimulant N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00008C1FCA ITSN1 27087310 direct interaction,inhibition N/A NPInter

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