GENE:NUP58
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | NUP58 |
| FullNmae | nucleoporin 58 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:20261 |
| EnsembleID | ENSG00000139496 |
| Uniprot | Q9BVL2 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| NUP58 | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| NUP58 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| NUP58 | GO:0005515,GO:0005635,GO:0005635,GO:0005643,GO:0005643,GO:0006913,GO:0008139,GO:0015031,GO:0017056,GO:0031965,GO:0042306,GO:0042802,GO:0044877,GO:0051028 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| NUP58 | hsa:9818 | path:hsa03013 | Nucleocytoplasmic transport - Homo sapiens (human) |
| NUP58 | hsa:9818 | path:hsa05014 | Amyotrophic lateral sclerosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | NUP58 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| HIF1A | NUP58 | 19828020 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| YBX1 | NUP58 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | NUP58 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | NUP58 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | NUP58 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | NUP58 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | NUP58 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | NUP58 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | NUP58 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000508C13 | NUP58 | N/A 15685193 | rna interference,inhibition | array technology | miRSponge |
| URS0000508C13 | NUP58 | 15685193 25416803 | mrna cleavage,inhibition | array technology,array technology,experimental interaction detection | TarBase |
| URS00000AA464 | NUP58 | 20304954 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00000ED600 | NUP58 | 20215506 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00000DDD35 | NUP58 | 20371350 25416803 | mrna cleavage,inhibition | nucleotide sequence identification | TarBase |
| URS00000BE495 | NUP58 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000031E12 | NUP58 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00004CD810 | NUP58 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000195F5B | NUP58 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003ACE11 | NUP58 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002ECEE4 | NUP58 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000043D2C1 | NUP58 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004BC299 | NUP58 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000000E601 | NUP58 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000027080C | NUP58 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000272039 | NUP58 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| RNF40 | NUP58 | 25348397 | N/A | physical interaction | ComPPI |
| MEIS2 | NUP58 | 25348397 | N/A | two hybrid | ComPPI |
| NUP62 | NUP58 | 11266456 14525934 21516116 24234451 25348397 25416956 26496610 | association,physical association | anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vitro,two hybrid prey pooling approach,validated two hybrid | ComPPI,HPRD,IntAct |
| VCP | NUP58 | 25348397 | N/A | physical interaction | ComPPI |
| KRT33B | NUP58 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| MAPK3 | NUP58 | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| CPNE2 | NUP58 | 25348397 | N/A | physical interaction | ComPPI |
| APC | NUP58 | 20936779 24234451 25348397 | physical association | physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach | ComPPI,IntAct |
| LAMTOR3 | NUP58 | 25348397 | N/A | physical interaction | ComPPI |
| EEA1 | NUP58 | 25348397 | N/A | physical interaction | ComPPI |
| NUP98 | NUP58 | 25348397 | N/A | anti tag coimmunoprecipitation,physical interaction | ComPPI |
| TRAF1 | NUP58 | 24234451 25348397 25416956 27107012 | physical association | physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid,barcode fusion genetics two hybrid | ComPPI,IntAct |
| UBQLN2 | NUP58 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| ABI3 | NUP58 | 21516116 24234451 25348397 25416956 | physical association | two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
| HTT | NUP58 | 17500595 23275563 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid prey pooling approach | ComPPI,IntAct |
| RANBP2 | NUP58 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| HNRNPH1 | NUP58 | 25348397 | N/A | physical interaction | ComPPI |
| GOPC | NUP58 | 25348397 | N/A | physical interaction | ComPPI |
| UBQLN1 | NUP58 | 25348397 | N/A | physical interaction | ComPPI |
| NUP54 | NUP58 | 24234451 25348397 25416956 26496610 30021884 | association,physical association | anti tag coimmunoprecipitation,cross-linking study,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
| PHF21A | NUP58 | 25348397 | N/A | physical interaction | ComPPI |
| PKNOX1 | NUP58 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| NUP214 | NUP58 | 25348397 | N/A | physical interaction | ComPPI |
| NUP107 | NUP58 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| IFI16 | NUP58 | 25348397 | N/A | physical interaction | ComPPI |
| NUP58 | ILF3 | 25348397 | N/A | physical interaction | ComPPI |
| NUP58 | TOMM40 | 25348397 | N/A | physical interaction | ComPPI |
| NUP58 | OBSL1 | 25348397 | N/A | physical interaction | ComPPI |
| NUP58 | SCLT1 | 24234451 25348397 26638075 | association | physical interaction,proximity-dependent biotin identification | ComPPI,IntAct |
| NUP58 | DMD | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| NUP58 | NUP93 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| NUP58 | NUP205 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| NUP58 | MIB2 | 25348397 | N/A | physical interaction | ComPPI |
