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GENE：LAPTM5

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol LAPTM5
FullNmae lysosomal protein transmembrane 5
LocusType gene with protein product
Status Approved
HGNC_id HGNC:29612
EnsembleID ENSG00000162511
Uniprot Q13571

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
LAPTM5 lysosomal_cd 36341760 220 lysosome-dependent cell death genes. retulator signature
LAPTM5 lysosomal_cd 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
LAPTM5 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
LAPTM5 GO:0002357,GO:0002720,GO:0005515,GO:0005764,GO:0005765,GO:0005765,GO:0005829,GO:0005886,GO:0006622,GO:0006886,GO:0006919,GO:0012502,GO:0030133,GO:0031398,GO:0031410,GO:0031625,GO:0032689,GO:0032703,GO:0032735,GO:0032991,GO:0043410,GO:0048471,GO:0050860,GO:0050868,GO:0050869,GO:0060907,GO:0090160,GO:0097214,GO:0140036,GO:0140311,GO:1901224,GO:1903265,GO:1904093,GO:2000060,GO:2000646

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
LAPTM5 hsa:7805 path:hsa04142 Lysosome - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
LAPTM5 SMURF2 15231748 23180781 physical association two hybrid InnateDB

Source Target Pmid Interactiontype Methods Database
AR LAPTM5 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 LAPTM5 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 LAPTM5 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 LAPTM5 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 LAPTM5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA LAPTM5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF LAPTM5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 LAPTM5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS LAPTM5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A LAPTM5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF LAPTM5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 LAPTM5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 LAPTM5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR LAPTM5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 LAPTM5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 LAPTM5 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 LAPTM5 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS0000170D8B LAPTM5 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00004AD450 LAPTM5 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000000EF0B LAPTM5 22100165 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
LAPTM5 NEDD4 25361965 interaction type N/A PTMCode2
NEDD4 LAPTM5 25361965 interaction type N/A PTMCode2
GGA3 LAPTM5 25361965 interaction type N/A PTMCode2
LAPTM5 GGA3 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
BAG3 LAPTM5 25348397 N/A physical interaction ComPPI
TNFAIP3 LAPTM5 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
DCUN1D1 LAPTM5 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
LAPTM5 DISP1 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
LAPTM5 SMURF2 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
LAPTM5 HERC1 14525934 15231748 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
LAPTM5 HEY1 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
LAPTM5 KRT7 14525934 15231748 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
LAPTM5 ANKRD13A 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
LAPTM5 EPN3 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
LAPTM5 UBC 25348397 N/A two hybrid,physical interaction ComPPI
LAPTM5 UBA52 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
LAPTM5 USP13 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
LAPTM5 WWP1 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
LAPTM5 RNF168 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
LAPTM5 EPS15 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
LAPTM5 EPN1 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
LAPTM5 HUWE1 14525934 15231748 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
LAPTM5 EPN2 14525934 15231748 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
LAPTM5 TOM1L2 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
LAPTM5 HEYL 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
LAPTM5 NEDD4 15231748 17116753 19953087 21765395 24234451 25348397 27898060 physical association two hybrid,physical interaction ComPPI,IntAct,OmniPath
LAPTM5 GGA3 25348397 N/A physical interaction ComPPI
LAPTM5 ITCH 25348397 N/A physical interaction ComPPI
LAPTM5 LAMP1 25348397 N/A physical interaction ComPPI
LAPTM5 LDLRAD1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
LAPTM5 INSIG2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LAPTM5 CYB5R3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LAPTM5 RTP2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LAPTM5 GYPA 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LAPTM5 RPRM 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LAPTM5 HMOX2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
UBB LAPTM5 25348397 N/A two hybrid ComPPI
RPS27A LAPTM5 25348397 N/A two hybrid ComPPI
UBAC1 LAPTM5 14525934 15231748 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
NEDD4L LAPTM5 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
HNRNPC LAPTM5 24234451 30021884 physical association cross-linking study IntAct

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