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GENE：ARFGEF2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ARFGEF2
FullNmae ADP ribosylation factor guanine nucleotide exchange factor 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:15853
EnsembleID ENSG00000124198
Uniprot Q9Y6D5

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ARFGEF2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ARFGEF2 GO:0000139,GO:0001881,GO:0005085,GO:0005515,GO:0005794,GO:0005802,GO:0005815,GO:0005829,GO:0005879,GO:0006887,GO:0006893,GO:0007032,GO:0010256,GO:0015031,GO:0016020,GO:0016020,GO:0017022,GO:0031410,GO:0032012,GO:0032279,GO:0032280,GO:0032760,GO:0034237,GO:0035556,GO:0043197,GO:0043231,GO:0048471,GO:0050811,GO:0055037,GO:0098793,GO:0098978,GO:0098982

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ARFGEF2 hsa:10564 path:hsa04144 Endocytosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TNFRSF1A ARFGEF2 17276987 23180781 physical association anti tag coimmunoprecipitation InnateDB
ERAP1 ARFGEF2 17276987 23180781 physical association anti tag coimmunoprecipitation InnateDB
NUCB2 ARFGEF2 17276987 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR ARFGEF2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 ARFGEF2 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 ARFGEF2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 ARFGEF2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
NR1I2 ARFGEF2 19129222 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 ARFGEF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ARFGEF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ARFGEF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 ARFGEF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ARFGEF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ARFGEF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ARFGEF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HIF1A ARFGEF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ARFGEF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF ARFGEF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 ARFGEF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001012BC ARFGEF2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00005651EE ARFGEF2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000042E1F ARFGEF2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002FC5B0 ARFGEF2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00001A7F58 ARFGEF2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000237AF9 ARFGEF2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000039607D ARFGEF2 24374217 25416803 mrna cleavage,inhibition clip TarBase
URS000042B108 ARFGEF2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001B0D1E ARFGEF2 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PDE3A ARFGEF2 25361965 interaction type N/A PTMCode2
ARFGEF2 PDE3A 25361965 interaction type N/A PTMCode2
ARFGEF1 ARFGEF2 25361965 interaction type N/A PTMCode2
ARFGEF2 ARFGEF1 25361965 interaction type N/A PTMCode2
FKBP2 ARFGEF2 25361965 interaction type N/A PTMCode2
ARFGEF2 FKBP2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
VASN ARFGEF2 25348397 N/A physical interaction ComPPI
SNW1 ARFGEF2 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CDC73 ARFGEF2 25348397 N/A physical interaction ComPPI
PPP1CC ARFGEF2 17360629 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKAR2B ARFGEF2 18625701 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,confocal microscopy ComPPI,IntAct
VCP ARFGEF2 25348397 N/A physical interaction ComPPI
SLAMF1 ARFGEF2 25348397 N/A physical interaction ComPPI
FLNC ARFGEF2 25348397 N/A physical interaction ComPPI
FLNA ARFGEF2 25348397 N/A physical interaction ComPPI
PRKAR1A ARFGEF2 12571360 14525934 19332778 24234451 25348397 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD,IntAct
PRPF40A ARFGEF2 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
TNFRSF1A ARFGEF2 17276987 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,confocal microscopy ComPPI,IntAct
DNAJB2 ARFGEF2 25348397 N/A physical interaction ComPPI
PRKAR2A ARFGEF2 12571360 14525934 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
NUP98 ARFGEF2 25348397 N/A physical interaction ComPPI
PNPLA2 ARFGEF2 25348397 N/A physical interaction ComPPI
FKBP2 ARFGEF2 25348397 N/A physical interaction ComPPI
ARFGEF1 ARFGEF2 10716990 14525934 19332778 22084092 24234451 25348397 27898060 colocalization,association,physical association anti bait coimmunoprecipitation,experimental interaction detection,molecular sieving,physical interaction ComPPI,HPRD,IntAct,OmniPath
MYCBP ARFGEF2 16866877 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,two hybrid,imaging technique ComPPI,IntAct
CD244 ARFGEF2 25348397 N/A physical interaction ComPPI
PDCD1 ARFGEF2 25348397 N/A physical interaction ComPPI
TRIM25 ARFGEF2 25348397 N/A physical interaction ComPPI
HLA-B ARFGEF2 25348397 N/A physical interaction ComPPI
HLA-E ARFGEF2 25348397 N/A physical interaction ComPPI
GYPB ARFGEF2 25348397 N/A physical interaction ComPPI
CD79B ARFGEF2 25348397 N/A physical interaction ComPPI
EDNRB ARFGEF2 25348397 N/A physical interaction ComPPI
NUP88 ARFGEF2 25348397 N/A physical interaction ComPPI
DTNBP1 ARFGEF2 25348397 N/A physical interaction ComPPI
BRCA1 ARFGEF2 25348397 N/A physical interaction ComPPI
TGOLN2 ARFGEF2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ICAM1 ARFGEF2 25348397 N/A physical interaction ComPPI
TMEM9B ARFGEF2 25348397 N/A physical interaction ComPPI
MADCAM1 ARFGEF2 25348397 N/A physical interaction ComPPI
EXOC7 ARFGEF2 14525934 15705715 24234451 25348397 27898060 colocalization cosedimentation through density gradient,imaging technique,two hybrid ComPPI,HPRD,IntAct,OmniPath
ARFGEF2 PAF1 25348397 N/A physical interaction ComPPI
ARFGEF2 SPACA1 25348397 N/A physical interaction ComPPI
ARFGEF2 TMEM171 25348397 N/A physical interaction ComPPI
ARFGEF2 CSGALNACT1 25348397 N/A physical interaction ComPPI
ARFGEF2 SDF4 25348397 N/A physical interaction ComPPI
ARFGEF2 LDLRAD4 25348397 N/A physical interaction ComPPI
ARFGEF2 ANKMY2 25348397 N/A physical interaction ComPPI
ARFGEF2 LAMP3 25348397 N/A physical interaction ComPPI
ARFGEF2 FAM131B 25348397 N/A physical interaction ComPPI
ARFGEF2 MRAP2 25348397 N/A physical interaction ComPPI
ARFGEF2 SIGLECL1 25348397 N/A physical interaction ComPPI
ARFGEF2 PDE3A 19332778 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ARFGEF2 GABRB3 14525934 15198677 N/A experimental interaction detection,two hybrid HPRD
ARFGEF2 GABRB2 14525934 15198677 N/A two hybrid HPRD
ARFGEF2 GABRB1 14525934 15198677 N/A two hybrid HPRD
ARFGEF2 TNFRSF1A 17276987 27898060 N/A N/A OmniPath

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