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GENE：GNB1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol GNB1
FullNmae G protein subunit beta 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4396
EnsembleID ENSG00000078369
Uniprot P62873

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
GNB1 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
GNB1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
GNB1 GO:0003924,GO:0005515,GO:0005737,GO:0005765,GO:0005829,GO:0005834,GO:0005834,GO:0005886,GO:0007165,GO:0007186,GO:0007191,GO:0007200,GO:0007213,GO:0007265,GO:0008283,GO:0016020,GO:0030159,GO:0044877,GO:0045202,GO:0050909,GO:0051020,GO:0060041,GO:0070062,GO:0071380,GO:0071870,GO:0097381,GO:1903561

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
GNB1 hsa:2782 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
GNB1 hsa:2782 path:hsa04062 Chemokine signaling pathway - Homo sapiens (human)
GNB1 hsa:2782 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
GNB1 hsa:2782 path:hsa04371 Apelin signaling pathway - Homo sapiens (human)
GNB1 hsa:2782 path:hsa04713 Circadian entrainment - Homo sapiens (human)
GNB1 hsa:2782 path:hsa04723 Retrograde endocannabinoid signaling - Homo sapiens (human)
GNB1 hsa:2782 path:hsa04724 Glutamatergic synapse - Homo sapiens (human)
GNB1 hsa:2782 path:hsa04725 Cholinergic synapse - Homo sapiens (human)
GNB1 hsa:2782 path:hsa04726 Serotonergic synapse - Homo sapiens (human)
GNB1 hsa:2782 path:hsa04727 GABAergic synapse - Homo sapiens (human)
GNB1 hsa:2782 path:hsa04728 Dopaminergic synapse - Homo sapiens (human)
GNB1 hsa:2782 path:hsa04740 Olfactory transduction - Homo sapiens (human)
GNB1 hsa:2782 path:hsa04744 Phototransduction - Homo sapiens (human)
GNB1 hsa:2782 path:hsa04926 Relaxin signaling pathway - Homo sapiens (human)
GNB1 hsa:2782 path:hsa05032 Morphine addiction - Homo sapiens (human)
GNB1 hsa:2782 path:hsa05034 Alcoholism - Homo sapiens (human)
GNB1 hsa:2782 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
GNB1 hsa:2782 path:hsa05167 Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)
GNB1 hsa:2782 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)
GNB1 hsa:2782 path:hsa05200 Pathways in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
GNG4 GNB1 20005715 interaction type N/A PSP

Source Target Pmid Interactiontype Methods Database
ESR1 GNB1 18414489 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation array,chromatin immunoprecipitation assay TFlink
ETS1 GNB1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 GNB1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 GNB1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 GNB1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 GNB1 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
MYC GNB1 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
YBX1 GNB1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TFAP2C GNB1 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 GNB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA GNB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF GNB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 GNB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 GNB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS GNB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A GNB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF GNB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 GNB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 GNB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00004214BB GNB1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000039E1E1 GNB1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002075FA GNB1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000324096 GNB1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000077AED GNB1 24374217 25416803 mrna cleavage,inhibition clip TarBase
URS00002C83DA GNB1 20371350 21572407 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00006DE17B GNB1 21572407 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075BDAA GNB1 20371350 21572407 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000007D64A GNB1 20371350 21572407 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000F0F49 GNB1 20371350 21572407 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000040EE1D GNB1 20371350 21572407 22473208 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000041CB9C GNB1 20371350 21572407 22473208 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000171CD1 GNB1 20371350 21572407 22473208 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000059EB31 GNB1 20371350 21572407 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000B0E50 GNB1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000045B99E GNB1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000005481D GNB1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000070CD2 GNB1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000427B68 GNB1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001AFC71 GNB1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000028BB8 GNB1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000036AFF1 GNB1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000075E538 GNB1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000136174 GNB1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00004C5774 GNB1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000057FDB8 GNB1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001012BC GNB1 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
GNG2 GNB1 25361965 interaction type N/A PTMCode2
GNB1 GNG2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GNAI3 GNB1 25348397 N/A physical interaction ComPPI
GNG5 GNB1 14525934 24234451 25348397 25416956 8636150 physical association two hybrid,physical interaction,mammalian protein protein interaction trap,two hybrid ComPPI,HPRD,IntAct
MAD2L2 GNB1 24234451 25348397 29656893 association anti tag coimmunoprecipitation ComPPI,IntAct
GNGT1 GNB1 14525934 25348397 8636150 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
GNG10 GNB1 25348397 N/A physical interaction,in vitro ComPPI
GNG11 GNB1 14525934 25348397 7665596 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
NUDCD3 GNB1 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
RACK1 GNB1 12359736 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
ERBB2 GNB1 24189400 24234451 25348397 association tandem affinity purification ComPPI,IntAct
PAK1 GNB1 25348397 N/A physical interaction ComPPI
BTK GNB1 25348397 N/A physical interaction ComPPI
PIK3R1 GNB1 25348397 N/A physical interaction ComPPI
CD81 GNB1 24234451 25348397 30024968 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
JUN GNB1 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
HDAC4 GNB1 25348397 N/A physical interaction ComPPI
GLI1 GNB1 25348397 N/A physical interaction ComPPI
MCF2 GNB1 10518015 25348397 27898060 N/A physical interaction ComPPI,OmniPath
ARHGEF18 GNB1 14512443 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
MCF2L GNB1 25348397 N/A physical interaction ComPPI
PTH1R GNB1 14525934 16099817 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
KALRN GNB1 25348397 N/A physical interaction ComPPI
PIK3CB GNB1 25348397 N/A physical interaction ComPPI
PIK3CA GNB1 25348397 N/A physical interaction ComPPI
GNAQ GNB1 25348397 N/A physical interaction ComPPI
RASD2 GNB1 25348397 N/A physical interaction ComPPI
NTRK1 GNB1 25348397 N/A physical interaction ComPPI
CANX GNB1 24234451 25348397 29568061 association pull down ComPPI,IntAct
STIP1 GNB1 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
SPAG1 GNB1 16368546 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PDLIM7 GNB1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAP1A GNB1 25348397 N/A physical interaction ComPPI
XPO1 GNB1 25348397 N/A physical interaction ComPPI
ARRB1 GNB1 25348397 N/A physical interaction ComPPI
GRK2 GNB1 25348397 N/A physical interaction ComPPI
ABCE1 GNB1 25348397 N/A physical interaction ComPPI
AVPR2 GNB1 25348397 N/A physical interaction ComPPI
ADRB2 GNB1 25348397 N/A physical interaction ComPPI
CUL4A GNB1 25348397 N/A physical interaction ComPPI
CACNA1A GNB1 14525934 25348397 9009193 N/A experimental interaction detection,in vitro ComPPI,HPRD
HTT GNB1 17500595 24234451 25348397 association pull down ComPPI,IntAct
CCT5 GNB1 25348397 N/A physical interaction ComPPI
PFDN5 GNB1 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
PSMD2 GNB1 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
RIPK3 GNB1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
ATP6V1B1 GNB1 25348397 N/A physical interaction ComPPI
VCAM1 GNB1 19738201 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
NCF2 GNB1 16782902 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FYN GNB1 25348397 N/A physical interaction ComPPI
NR3C1 GNB1 25348397 N/A physical interaction ComPPI
HDAC5 GNB1 14525934 16221676 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
GNG2 GNB1 11294873 14525934 23739333 24234451 25348397 8636150 physical association two hybrid,experimental interaction detection,molecular sieving,pull down,x-ray crystallography,physical interaction,ion exchange chromatography,in vivo,two hybrid ComPPI,HPRD,IntAct
CYFIP1 GNB1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SVIL GNB1 25348397 N/A physical interaction ComPPI
PDCL GNB1 14525934 15889144 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
GNA11 GNB1 25348397 N/A physical interaction ComPPI
TRIM25 GNB1 25348397 N/A physical interaction ComPPI
GNAS GNB1 25348397 N/A physical interaction ComPPI
MTNR1A GNB1 14525934 17215244 24234451 25348397 26514267 association experimental interaction detection,physical interaction,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
ELAVL1 GNB1 25348397 N/A physical interaction ComPPI
UBQLN1 GNB1 25348397 N/A physical interaction ComPPI
KCNJ3 GNB1 12743112 14525934 25348397 27898060 9108307 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
CACNA1B GNB1 14525934 15953418 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
ESR1 GNB1 21182205 24234451 25348397 association affinity chromatography technology,physical interaction ComPPI,IntAct
MTOR GNB1 24462769 25348397 27898060 N/A physical interaction ComPPI,OmniPath
EPHA7 GNB1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
AKT1 GNB1 25348397 N/A physical interaction ComPPI
MAP3K3 GNB1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
GNAI2 GNB1 16782902 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ESRRB GNB1 25348397 N/A physical interaction ComPPI
SOD1 GNB1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
ATP6V1A GNB1 21674799 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
SYNPO GNB1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CACNA1C GNB1 25348397 N/A two hybrid ComPPI
GNG12 GNB1 25348397 N/A physical interaction ComPPI
GNAI1 GNB1 25348397 N/A physical interaction ComPPI
RGS6 GNB1 25348397 N/A physical interaction ComPPI
PAN2 GNB1 25348397 N/A physical interaction ComPPI
RPTOR GNB1 25348397 N/A physical interaction ComPPI
RASD1 GNB1 14525934 16225846 25348397 27898060 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD,OmniPath
GNG7 GNB1 14525934 25348397 8308009 8636150 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
GNG4 GNB1 14525934 16884933 25348397 7665596 8636150 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
GNG13 GNB1 10570481 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PLEKHG2 GNB1 25348397 N/A physical interaction ComPPI
ADRA2A GNB1 25348397 N/A physical interaction ComPPI
GNB1 MTNR1B 14525934 17215244 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
GNB1 GNG3 11294873 14525934 25348397 8636150 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
GNB1 DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GNB1 WDR26 22065575 23625927 25348397 27898060 N/A physical interaction ComPPI,OmniPath
GNB1 RADIL 25348397 N/A physical interaction ComPPI
GNB1 ATXN10 25348397 N/A physical interaction ComPPI
GNB1 MRGPRX1 25348397 N/A physical interaction ComPPI
GNB1 TBXA2R 25348397 N/A physical interaction ComPPI
GNB1 GNAS 25348397 N/A physical interaction ComPPI
GNB1 GNAS 25348397 N/A physical interaction ComPPI
GNB1 NOL11 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
GNB1 AFP 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
GNB1 GNG8 25348397 N/A physical interaction ComPPI
GNB1 RICTOR 25348397 N/A physical interaction ComPPI
GNB1 CCDC8 25348397 N/A physical interaction ComPPI
GNB1 PTK2 25348397 N/A physical interaction ComPPI
GNB1 CEP128 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
GNB1 DUSP9 25348397 N/A physical interaction ComPPI
GNB1 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
GNB1 HSD17B10 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
GNB1 AKT2 25348397 N/A physical interaction ComPPI
GNB1 MCC 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
GNB1 MLF1 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
GNB1 VAC14 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GNB1 HACD1 24234451 25348397 28330616 association pull down ComPPI,IntAct
GNB1 KSR1 24234451 25348397 27086506 association anti tag coimmunoprecipitation ComPPI,IntAct
GNB1 PLEKHA7 24234451 25348397 28877994 association anti bait coimmunoprecipitation ComPPI,IntAct
COX4I1 GNB1 25348397 N/A physical interaction ComPPI
GNA12 GNB1 14525934 7829508 N/A experimental interaction detection HPRD
L1TD1 GNB1 24234451 25702638 association anti bait coimmunoprecipitation IntAct
ADCY5 GNB1 17110384 27898060 N/A N/A OmniPath
NME2 GNB1 12486122 27898060 N/A N/A OmniPath
GNB1 PLCB1 27898060 8870665 inhibition,stimulant N/A OmniPath
GNB1 PLCB2 1465133 27898060 stimulant N/A OmniPath
SMO GNB1 16885213 23074268 27898060 stimulant N/A OmniPath
GNB1 PIK3CA 16537363 27898060 stimulant N/A OmniPath
FZD3 GNB1 17251915 27898060 stimulant N/A OmniPath
PHPT1 GNB1 16039992 27898060 N/A N/A OmniPath

Visualization










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