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GENE：AP2A2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol AP2A2
FullNmae adaptor related protein complex 2 subunit alpha 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:562
EnsembleID ENSG00000183020
Uniprot O94973

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
AP2A2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
AP2A2 GO:0003674,GO:0005515,GO:0005829,GO:0005886,GO:0006886,GO:0008289,GO:0009898,GO:0016192,GO:0019901,GO:0030122,GO:0030122,GO:0030122,GO:0030122,GO:0030666,GO:0030667,GO:0030669,GO:0031410,GO:0035615,GO:0035615,GO:0036020,GO:0045334,GO:0072583,GO:0072583,GO:0072583,GO:0072583,GO:0072583,GO:0097718,GO:0098794,GO:0098884,GO:0101003

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
AP2A2 hsa:161 path:hsa04144 Endocytosis - Homo sapiens (human)
AP2A2 hsa:161 path:hsa04721 Synaptic vesicle cycle - Homo sapiens (human)
AP2A2 hsa:161 path:hsa04961 Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human)
AP2A2 hsa:161 path:hsa05016 Huntington disease - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AP2A2 AP2A1 15749704 15911768 26192618 interaction type N/A ACSN
AP2B1 AP2A2 15749704 15911768 26192618 interaction type N/A ACSN
AP2M1 AP2A2 15749704 15911768 26192618 interaction type N/A ACSN
AP2S1 AP2A2 15749704 15911768 26192618 interaction type N/A ACSN
AP2A2 CD74 15749704 15911768 26192618 interaction type N/A ACSN

Source Target Pmid Interactiontype Methods Database
ETS1 AP2A2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 AP2A2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TFAP2C AP2A2 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 AP2A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA AP2A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF AP2A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 AP2A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 AP2A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 AP2A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 AP2A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A AP2A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF AP2A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 AP2A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 AP2A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 AP2A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000EED18 AP2A2 21566225 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS0000070B1D AP2A2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000EC1BE AP2A2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001A7F58 AP2A2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001597DC AP2A2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000DDD35 AP2A2 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
HTT AP2A2 25361965 interaction type N/A PTMCode2
AP2A2 HTT 25361965 interaction type N/A PTMCode2
AP2M1 AP2A2 25361965 interaction type N/A PTMCode2
AP2A2 AP2M1 25361965 interaction type N/A PTMCode2
AMPH AP2A2 25361965 interaction type N/A PTMCode2
AP2A2 AMPH 25361965 interaction type N/A PTMCode2
AP2S1 AP2A2 25361965 interaction type N/A PTMCode2
AP2A2 AP2S1 25361965 interaction type N/A PTMCode2
SHC1 AP2A2 25361965 interaction type N/A PTMCode2
AP2A2 SHC1 25361965 interaction type N/A PTMCode2
AP1B1 AP2A2 25361965 interaction type N/A PTMCode2
AP2A2 AP1B1 25361965 interaction type N/A PTMCode2
EPN1 AP2A2 25361965 interaction type N/A PTMCode2
AP2A2 EPN1 25361965 interaction type N/A PTMCode2
CLTC AP2A2 25361965 interaction type N/A PTMCode2
AP2A2 CLTC 25361965 interaction type N/A PTMCode2
NUMB AP2A2 25361965 interaction type N/A PTMCode2
AP2A2 NUMB 25361965 interaction type N/A PTMCode2
EPS15 AP2A2 25361965 interaction type N/A PTMCode2
AP2A2 EPS15 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
UTP25 AP2A2 25348397 N/A physical interaction ComPPI
NUTF2 AP2A2 25348397 N/A physical interaction ComPPI
VCP AP2A2 25348397 N/A physical interaction ComPPI
MCM2 AP2A2 25348397 N/A physical interaction ComPPI
SMAD1 AP2A2 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
DAB2 AP2A2 22323290 24234451 25348397 colocalization physical interaction,confocal microscopy ComPPI,IntAct
SHC1 AP2A2 14525934 19380743 24189400 24234451 25348397 8617812 association experimental interaction detection,physical interaction,in vitro,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
GRB2 AP2A2 25348397 N/A physical interaction ComPPI
UBC AP2A2 25348397 N/A physical interaction ComPPI
NTRK1 AP2A2 25348397 N/A physical interaction ComPPI
SNAP91 AP2A2 10430869 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
YBX1 AP2A2 25348397 N/A physical interaction ComPPI
NUMB AP2A2 14525934 17203073 23211419 24234451 25348397 association anti bait coimmunoprecipitation,experimental interaction detection,in vivo ComPPI,HPRD,IntAct
DNM1 AP2A2 10430869 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
RPA1 AP2A2 25348397 N/A physical interaction ComPPI
IQGAP1 AP2A2 25348397 N/A physical interaction ComPPI
AP2A2 AMPH 10748223 14525934 25348397 8552632 9195986 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
AP2A2 AP2B1 25348397 N/A physical interaction,in vitro ComPPI
AP2A2 BIN1 10430869 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
AP2A2 AP1S1 11707398 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
AP2A2 EPN1 12057195 14525934 25348397 9723620 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
AP2A2 EPS15 14525934 19380743 24234451 25348397 8662627 9049247 association experimental interaction detection,physical interaction,in vitro,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
AP2A2 DNAJC6 11470803 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
AP2A2 HTT 14525934 17500595 24234451 25348397 9700202 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
AP2A2 CLTC 25348397 N/A physical interaction ComPPI
AP2A2 TERF2 25348397 N/A physical interaction ComPPI
AP2A2 ARRB2 17620599 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
AP2A2 GRK5 25348397 N/A physical interaction ComPPI
AP2A2 AP2M1 19380743 24189400 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
AP2A2 APP 25348397 N/A physical interaction ComPPI
AP2A2 AP2A1 25348397 N/A physical interaction ComPPI
AP2A2 FN1 19738201 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
AP2A2 PAN2 25348397 N/A physical interaction ComPPI
AP2A2 EGFR 24189400 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
AP2A2 PPP6R3 25348397 N/A physical interaction ComPPI
AP2A2 RPA3 25348397 N/A physical interaction ComPPI
AP2A2 RPA2 25348397 N/A physical interaction ComPPI
AP2A2 PIP5K1C 25348397 N/A physical interaction ComPPI
AP2A2 ATP1A1 25348397 N/A physical interaction ComPPI
AP2A2 MOV10 25348397 N/A physical interaction ComPPI
AP2A2 NXF1 25348397 N/A physical interaction ComPPI
AP2A2 NECAP2 25348397 N/A physical interaction ComPPI
AP2A2 AAGAB 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
AP2A2 ZBTB46 25348397 N/A physical interaction ComPPI
AP2A2 AP1B1 25348397 N/A physical interaction ComPPI
AP2A2 AP2S1 25348397 N/A physical interaction ComPPI
AP2A2 NAPA 25348397 N/A physical interaction ComPPI
AP2A2 EIF2B1 25348397 N/A physical interaction ComPPI
AP2A2 CLTB 25348397 N/A physical interaction ComPPI
AP2A2 DBN1 25348397 N/A physical interaction ComPPI
AP2A2 GAK 25348397 N/A physical interaction ComPPI
AP2A2 KIF11 25348397 N/A physical interaction ComPPI
AP2A2 FAN1 25348397 N/A physical interaction ComPPI
AP2A2 LIMA1 25348397 N/A physical interaction ComPPI
AP2A2 GTSE1 25348397 N/A physical interaction ComPPI
AP2A2 ESR1 25348397 N/A physical interaction ComPPI
AP2A2 MEX3C 25348397 N/A physical interaction ComPPI
AP2A2 RNF126 25348397 N/A physical interaction ComPPI
AP2A2 NLGN3 25348397 N/A physical interaction ComPPI
AP2A2 MYO6 25348397 N/A physical interaction ComPPI
AP2A2 MTMR4 25348397 N/A physical interaction ComPPI
AP2A2 RUNDC3A 25348397 N/A physical interaction ComPPI
AP2A2 ARFGAP1 25348397 N/A physical interaction ComPPI
AP2A2 SNX9 25348397 N/A physical interaction ComPPI
AP2A2 GPBP1L1 25348397 N/A physical interaction ComPPI
AP2A2 GPR156 25348397 N/A physical interaction ComPPI
AP2A2 CLINT1 25348397 N/A physical interaction ComPPI
AP2A2 FCHO1 25348397 N/A physical interaction ComPPI
AP2A2 REPS1 25348397 N/A physical interaction ComPPI
AP2A2 LSR 25348397 N/A physical interaction ComPPI
AP2A2 CPSF4L 25348397 N/A physical interaction ComPPI
AP2A2 INTS4 25348397 N/A physical interaction ComPPI
AP2A2 OCRL 24234451 25107275 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction,inference by socio-affinity scoring ComPPI,IntAct
AP2A2 SLC2A8 25348397 N/A physical interaction ComPPI
AP2A2 FCHO2 22323290 24234451 25348397 colocalization confocal microscopy ComPPI,IntAct
AP2A2 PLEKHA7 24234451 25348397 28877994 association anti bait coimmunoprecipitation ComPPI,IntAct
AP2A2 TGOLN2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
LRFN4 AP2A2 25348397 N/A physical interaction ComPPI
AP2A2 AP2A2 10430869 11707398 14525934 N/A experimental interaction detection HPRD
RBCK1 AP2A2 24234451 30561431 association virotrap IntAct
MAPT AP2A2 24234451 26402096 association anti bait coimmunoprecipitation IntAct
L1TD1 AP2A2 24234451 25702638 association anti bait coimmunoprecipitation IntAct
SYNJ1 AP2A2 10801423 27898060 N/A N/A OmniPath

Visualization










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