GENE：KCNK1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | KCNK1 |
| FullNmae | potassium two pore domain channel subfamily K member 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:6272 |
| EnsembleID | ENSG00000135750 |
| Uniprot | O00180 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| KCNK1 | pyroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| KCNK1 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| KCNK1 | GO:0005242,GO:0005267,GO:0005272,GO:0005515,GO:0005886,GO:0005886,GO:0005886,GO:0006813,GO:0008076,GO:0015271,GO:0016020,GO:0016324,GO:0022841,GO:0022841,GO:0030322,GO:0030425,GO:0031526,GO:0034705,GO:0035094,GO:0035725,GO:0042802,GO:0043204,GO:0043231,GO:0055037,GO:0060075,GO:0071805,GO:0071805,GO:0097060,GO:1902937 |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ESR1 | KCNK1 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA1 | KCNK1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | KCNK1 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA3 | KCNK1 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXA1 | KCNK1 | 18971253 21878914 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | KCNK1 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | KCNK1 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| PRDM14 | KCNK1 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | KCNK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | KCNK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | KCNK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | KCNK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | KCNK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | KCNK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | KCNK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000007FBA | KCNK1 | 20371350 25416803 | mrna cleavage,inhibition | nucleotide sequence identification | TarBase |
| URS00000CBE63 | KCNK1 | 20371350 25416803 | mrna cleavage,inhibition | nucleotide sequence identification | TarBase |
| URS0000427B68 | KCNK1 | 20371350 21572407 23446348 23706177 24398324 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00004719AB | KCNK1 | 20371350 21572407 23446348 23706177 24398324 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000076B539 | KCNK1 | 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000085F64 | KCNK1 | 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001A6D0C | KCNK1 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000029D9F1 | KCNK1 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003AD2AA | KCNK1 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000148B91 | KCNK1 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000007F792 | KCNK1 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| UBE2I | KCNK1 | 14525934 15820677 20498050 24234451 25348397 | physical association | two hybrid,fluorescent resonance energy transfer,physical interaction,two hybrid | ComPPI,HPRD,IntAct |
| LMNA | KCNK1 | 25348397 | N/A | physical interaction | ComPPI |
| SUMO1 | KCNK1 | 20498050 24234451 25348397 | covalent binding,physical association | fluorescent resonance energy transfer,pull down,covalent binding,physical interaction | ComPPI,IntAct |
| CREB3 | KCNK1 | 25348397 | N/A | physical interaction | ComPPI |
| ELAVL1 | KCNK1 | 25348397 | N/A | physical interaction | ComPPI |
| KCNK1 | KRTAP10-3 | 25348397 | N/A | physical interaction | ComPPI |
| KCNK1 | CREB3L1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| KCNK1 | CDIPT | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |