GENE：EN1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | EN1 |
| FullNmae | engrailed homeobox 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:3342 |
| EnsembleID | ENSG00000163064 |
| Uniprot | Q05925 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| EN1 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| EN1 | GO:0000122,GO:0000785,GO:0000978,GO:0000978,GO:0000981,GO:0000981,GO:0001227,GO:0001501,GO:0005634,GO:0005634,GO:0006357,GO:0008344,GO:0009653,GO:0009953,GO:0009954,GO:0021549,GO:0030182,GO:0030901,GO:0030917,GO:0035115,GO:0035176,GO:0035264,GO:0042220,GO:0042756,GO:0043473,GO:0043524,GO:0045944,GO:0048666,GO:0061743,GO:0071542,GO:1990403,GO:1990837 |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GATA1 | EN1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | EN1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | EN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | EN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | EN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | EN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | EN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | EN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | EN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | EN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | EN1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000024A59E | EN1 | 23592263 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS000023BE29 | EN1 | 20371350 23592263 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS0000156390 | EN1 | 20371350 23592263 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS0000324096 | EN1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00002F8148 | EN1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS0000427B68 | EN1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00001FFA8C | EN1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00000BE495 | EN1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS0000086A4D | EN1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS000031BC7D | EN1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS0000122ED0 | EN1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| TLE1 | EN1 | 16571670 18611861 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| JUN | EN1 | 11551904 14525934 25348397 | N/A | two hybrid,experimental interaction detection,in vitro,two hybrid | ComPPI,HPRD |
| EN1 | PAX6 | 11069920 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| BPTF | EN1 | 14609955 24234451 | association | chromatin immunoprecipitation assay | IntAct |
| SMARCA1 | EN1 | 14609955 24234451 | association | chromatin immunoprecipitation assay | IntAct |