GENE：GABBR2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | GABBR2 |
| FullNmae | gamma-aminobutyric acid type B receptor subunit 2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:4507 |
| EnsembleID | ENSG00000136928 |
| Uniprot | O75899 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| GABBR2 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| GABBR2 | GO:0004888,GO:0004965,GO:0005515,GO:0005737,GO:0005886,GO:0005886,GO:0007186,GO:0007193,GO:0007194,GO:0007214,GO:0007214,GO:0007268,GO:0038039,GO:0038039,GO:0043005,GO:0045211,GO:0046982,GO:0051932,GO:0150099,GO:1902710,GO:1902712 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| GABBR2 | hsa:9568 | path:hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
| GABBR2 | hsa:9568 | path:hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) |
| GABBR2 | hsa:9568 | path:hsa04727 | GABAergic synapse - Homo sapiens (human) |
| GABBR2 | hsa:9568 | path:hsa04742 | Taste transduction - Homo sapiens (human) |
| GABBR2 | hsa:9568 | path:hsa04915 | Estrogen signaling pathway - Homo sapiens (human) |
| GABBR2 | hsa:9568 | path:hsa04929 | GnRH secretion - Homo sapiens (human) |
| GABBR2 | hsa:9568 | path:hsa05032 | Morphine addiction - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | GABBR2 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ESR1 | GABBR2 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA1 | GABBR2 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | GABBR2 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA3 | GABBR2 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXA1 | GABBR2 | 18971253 21878914 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| PRDM14 | GABBR2 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | GABBR2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | GABBR2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | GABBR2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | GABBR2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ETS1 | GABBR2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | GABBR2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | GABBR2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HIF1A | GABBR2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | GABBR2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | GABBR2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | GABBR2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | GABBR2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | GABBR2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00005E6F45 | GABBR2 | 23824327 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS00002FF522 | GABBR2 | 23824327 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS00002C7B2B | GABBR2 | 25416803 25766675 | mrna cleavage,inhibition | miRNA interference luciferase reporter assay | TarBase |
| URS00002E92A8 | GABBR2 | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ATF4 | GABBR2 | 11087824 14525934 25348397 | N/A | two hybrid,physical interaction,two hybrid | ComPPI,HPRD |
| NSF | GABBR2 | 14525934 16724110 24234451 25348397 | colocalization,physical association | anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,imaging technique,in vitro,in vivo,two hybrid | ComPPI,HPRD,IntAct |
| SH3GL3 | GABBR2 | 14525934 16169070 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
| GABBR1 | GABBR2 | 10075644 14525934 16724110 24234451 24658140 25348397 9872316 | physical association | anti tag coimmunoprecipitation,two hybrid,cross-linking study,experimental interaction detection,molecular sieving,ubiquitin reconstruction,x-ray crystallography,physical interaction,in vitro,in vivo,two hybrid | ComPPI,HPRD,IntAct |
| AKT1 | GABBR2 | 25348397 | N/A | physical interaction | ComPPI |
| ATF5 | GABBR2 | 11087824 14525934 25348397 | N/A | two hybrid,two hybrid | ComPPI,HPRD |
| GABBR2 | DDIT3 | 25348397 | N/A | physical interaction | ComPPI |
| GABBR2 | DRD2 | 24234451 28298427 | physical association | ubiquitin reconstruction | IntAct |
| GABBR2 | GABBR1 | 10075644 10917635 16724110 24305054 24658140 26817839 27898060 9872316 | N/A | N/A | OmniPath |
| GABBR1 | GABBR2 | 10075644 10917635 16724110 24305054 24658140 26817839 27898060 9872316 | N/A | N/A | OmniPath |