Gene Information gene info

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GENE：DBF4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol DBF4
FullNmae DBF4-CDC7 kinase regulatory subunit
LocusType gene with protein product
Status Approved
HGNC_id HGNC:17364
EnsembleID ENSG00000006634
Uniprot Q9UBU7

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
DBF4 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
DBF4 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
DBF4 GO:0000082,GO:0003676,GO:0005515,GO:0005654,GO:0005654,GO:0006260,GO:0008047,GO:0008270,GO:0010571,GO:0016604,GO:0031431,GO:0043539,GO:1901987

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
DBF4 hsa:10926 path:hsa04110 Cell cycle - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
DBF4 CDC7 15279786 17018296 17102137 17116885 17296725 17303408 17582221 17660363 18590585 19793801 26192618 7575488 association N/A ACSN
DBF4 ORC1 15279786 17018296 17102137 17116885 17296725 17303408 17582221 17660363 18590585 19793801 26192618 7575488 interaction type N/A ACSN
DBF4 ORC2 15279786 17018296 17102137 17116885 17296725 17303408 17582221 17660363 18590585 19793801 26192618 7575488 interaction type N/A ACSN
DBF4 ORC3 15279786 17018296 17102137 17116885 17296725 17303408 17582221 17660363 18590585 19793801 26192618 7575488 interaction type N/A ACSN
DBF4 ORC4 15279786 17018296 17102137 17116885 17296725 17303408 17582221 17660363 18590585 19793801 26192618 7575488 interaction type N/A ACSN
DBF4 ORC5 15279786 17018296 17102137 17116885 17296725 17303408 17582221 17660363 18590585 19793801 26192618 7575488 interaction type N/A ACSN
DBF4 ORC6 15279786 17018296 17102137 17116885 17296725 17303408 17582221 17660363 18590585 19793801 26192618 7575488 interaction type N/A ACSN
DBF4 MCM2 15279786 17018296 17102137 17116885 17296725 17303408 17582221 17660363 18590585 19793801 26192618 7575488 interaction type N/A ACSN
DBF4 MCM3 15279786 17018296 17102137 17116885 17296725 17303408 17582221 17660363 18590585 19793801 26192618 7575488 interaction type N/A ACSN
DBF4 MCM4 15279786 17018296 17102137 17116885 17296725 17303408 17582221 17660363 18590585 19793801 26192618 7575488 interaction type N/A ACSN
DBF4 MCM5 15279786 17018296 17102137 17116885 17296725 17303408 17582221 17660363 18590585 19793801 26192618 7575488 interaction type N/A ACSN
DBF4 MCM6 15279786 17018296 17102137 17116885 17296725 17303408 17582221 17660363 18590585 19793801 26192618 7575488 interaction type N/A ACSN
DBF4 MCM7 15279786 17018296 17102137 17116885 17296725 17303408 17582221 17660363 18590585 19793801 26192618 7575488 interaction type N/A ACSN
DBF4 CDT1 15279786 17018296 17102137 17116885 17296725 17303408 17582221 17660363 18590585 19793801 26192618 7575488 interaction type N/A ACSN
DBF4 CDC6 15279786 17018296 17102137 17116885 17296725 17303408 17582221 17660363 18590585 19793801 26192618 7575488 interaction type N/A ACSN
DBF4 CDC45 15279786 17018296 17102137 17116885 17296725 17303408 17582221 17660363 18590585 19793801 26192618 7575488 interaction type N/A ACSN
DBF4 RPA1 15279786 17018296 17102137 17116885 17296725 17303408 17582221 17660363 18590585 19793801 26192618 7575488 interaction type N/A ACSN
DBF4 RPA2 15279786 17018296 17102137 17116885 17296725 17303408 17582221 17660363 18590585 19793801 26192618 7575488 interaction type N/A ACSN
DBF4 RPA3 15279786 17018296 17102137 17116885 17296725 17303408 17582221 17660363 18590585 19793801 26192618 7575488 interaction type N/A ACSN
HUS1 DBF4 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16885023 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 26192618 8943031 9524127 interaction type N/A ACSN
RAD1 DBF4 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16885023 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 26192618 8943031 9524127 interaction type N/A ACSN
RAD17 DBF4 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16885023 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 26192618 8943031 9524127 interaction type N/A ACSN

Source Target Pmid Interactiontype Methods Database
E2F1 DBF4 12015319 18503552 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
SMARCA4 DBF4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA DBF4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF DBF4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 DBF4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 DBF4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 DBF4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 DBF4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF DBF4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATD3B DBF4 12420215 trascriptional regulation,stimulation inferred by curator TFlink
HES1 DBF4 12420215 trascriptional regulation,stimulation inferred by curator TFlink
SP1 DBF4 12420215 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 DBF4 12420215 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000122ED0 DBF4 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS0000065D58 DBF4 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000005CF5F DBF4 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002152A8 DBF4 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00001DE669 DBF4 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E DBF4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000411752 DBF4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000753AD DBF4 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CDC7 DBF4 22135298 phosphorylation N/A PhosphoSite
ATR DBF4 22135298 phosphorylation N/A PhosphoSite
ATM DBF4 22135298 phosphorylation N/A PhosphoSite
MCM2 DBF4 25361965 interaction type N/A PTMCode2
DBF4 MCM2 25361965 interaction type N/A PTMCode2
DBF4 CHAF1A 25361965 interaction type N/A PTMCode2
CHAF1A DBF4 25361965 interaction type N/A PTMCode2
DBF4 MCM7 25361965 interaction type N/A PTMCode2
MCM7 DBF4 25361965 interaction type N/A PTMCode2
DBF4 CHEK2 25361965 interaction type N/A PTMCode2
CHEK2 DBF4 25361965 interaction type N/A PTMCode2
MCM4 DBF4 25361965 interaction type N/A PTMCode2
DBF4 MCM4 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
ORC1 DBF4 25348397 N/A physical interaction ComPPI
DAXX DBF4 25348397 N/A physical interaction ComPPI
MCM6 DBF4 25348397 N/A physical interaction ComPPI
MCM2 DBF4 12614612 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
ORC6 DBF4 25348397 N/A physical interaction ComPPI
ORC4 DBF4 25348397 N/A physical interaction ComPPI
LSM8 DBF4 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
CHAF1A DBF4 14525934 16826239 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD,IntAct
RAD18 DBF4 25348397 N/A physical interaction ComPPI
XPO1 DBF4 25348397 N/A physical interaction ComPPI
ORC2 DBF4 12441400 12614612 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
CDK2 DBF4 25348397 N/A physical interaction ComPPI
CHEK2 DBF4 12441400 14525934 25348397 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD
CDC7 DBF4 10373557 10523313 12614612 14525934 16899510 24234451 25348397 physical association two hybrid,experimental interaction detection,molecular sieving,pull down,x-ray crystallography,physical interaction,two hybrid array,in vitro,in vivo,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
MCM3 DBF4 25348397 N/A two hybrid,physical interaction ComPPI
ORC3 DBF4 12441400 14525934 25348397 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD
ORC5 DBF4 25348397 N/A physical interaction ComPPI
MCM4 DBF4 25348397 N/A physical interaction ComPPI
DBF4 MEN1 14525934 15374998 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
DBF4 MCM7 12614612 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
DBF4 BRCA1 25348397 N/A physical interaction ComPPI
DBF4 HDGFL2 25348397 N/A physical interaction ComPPI
DBF4 NME6 25348397 N/A physical interaction ComPPI
EEF1A2 DBF4 25348397 N/A physical interaction ComPPI
TARDBP DBF4 24234451 30021884 physical association cross-linking study IntAct
CDK1 DBF4 25287299 27898060 N/A N/A OmniPath
ATR DBF4 22123827 27898060 inhibition N/A OmniPath
ATM DBF4 22123827 27898060 inhibition N/A OmniPath
MEN1 DBF4 15374998 16997566 27898060 inhibition N/A OmniPath
E2F1 DBF4 18319725 18503552 27898060 stimulant N/A OmniPath

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